Results 141 to 150 of about 1,967,846 (356)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Epidermal Growth Factor Receptor (EGFR) as a Prognostic Marker: an Immunohistochemical Study on 315 Consecutive Breast Carcinoma Patients [PDF]

, 2002
Objective: To assess the independent and interdependent prognostic value of epidermal growth factor receptor (EGFR) in carcinoma of breast in female population.
Aziz, S. A., Kayani, N., Khan, S., Pervez, Shahid, Rahbar, M. H.   +4 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Impact of thyroid dysfunction on clinical outcome in head and neck cancer: a systematic review and meta-analysis

BMC Cancer
Background The influence of thyroid dysfunction on the clinical outcomes of head and neck cancer (HNC) patients remains an area of ongoing investigation, with previous studies yielding variable results.
Sandeepa N. C, Tina S. Roberts, Johan Frank Opperman, Johan Grobbelaar, Muhammed Ajmal   +4 more
doaj   +1 more source

AB0455 Survival of prednisone-free remission in sle patients with serologically active clinical quiescent disease [PDF]

, 2017
Linda Nalotto, Francesca Ometto, Margherita Zen, Leonardo Iaccarino, Mariele Gatto, Maddalena Larosa, Andrea Doria   +6 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Nomogram for predicting disease-free survival among a multicenter cohort of Chinese patients with locally advanced rectal cancer

Cancer Management and Research, 2019
Zhen-Hui Li,1 Pei-Yi Xie,2 Da-Fu Zhang,1 Ya-Jun Li,3,4 Lin Wu,5 Jian Dong,6 Jian Xiao,7 Zai-Yi Liu31Department of Radiology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650118, People’s Republic of ...
Li ZH, Xie PY, Zhang DF, Li YJ, Wu L, Dong J, Xiao J, Liu ZY   +7 more
doaj  

Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy [PDF]

, 2011
Juliana Schwaab, Karoline Horisberger, Philipp Ströbel, Beatrice Bohn, Deniz Gencer, Georg Kähler, Peter Kienle, Stefan Post, Frederik Wenz, Wolf‐Karsten Hofmann, Ralf‐Dieter Hofheinz, Philipp Erben   +11 more
openalex   +1 more source

2022-RA-963-ESGO The impact of low-volume metastasis on disease-free survival of women with apparent early-stage endometrial cancerunderwent sentinel node biopsy: a retrospective study [PDF]

, 2022
Alessandro A Buda, Cristiana Paniga, Salih Taşkın, Michael D. Mueller, Ignacio Zapardiel, Francesco Fanfani, Andrea Puppo, Andrea Papadia, Elena De Ponti, Hasan Turan, Stefania Perotto, Mete Güngör, Fırat Ortaç, Sara Imboden, Fabio Ghezzi, Giovanni Scambia, Çağatay Taşkıran, Robert Fruscio   +17 more
openalex   +1 more source