Results 131 to 140 of about 1,039,355 (265)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Preoperative nutritional status and sarcopenia are associated with disease-free survival in patients with resected pancreatic neuroendocrine tumors. [PDF]

Front Oncol
Li J, Lai M.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Prolonged disease-free survival with immunotherapy combined with chemotherapy in a patient with advanced stage large cell neuroendocrine carcinoma of the uterus. [PDF]

Gynecol Oncol Rep
Yoh K, Smithgall MC, Tessler G, Kulkarni A, Lenis AT, Ghiassi Z, Wright JD, Dioun S.   +7 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

IMPROVED DISEASE FREE SURVIVAL IN JMML. THE DUTCH EXPERIENCE.

EJC Paediatric Oncology
Dorine Bresters, Valérie de Haas, Martine Mol, Katja Heitink, Arjenne Kors, Mirjam Belderbos, Marco Koudijs, Esmé Waanders, Kirsten Thus, Marc Bierings   +9 more
doaj   +1 more source

High uPAR and Low miR-221 Expression Predict Poor Disease-Free Survival in Triple-Negative Breast Cancer. [PDF]

Pathophysiology
Gong W, Liu Y, Falkenberg N, Kiechle M, Bronger H, Dorn J, Magdolen V, Dreyer T.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Preoperative HALP and LMR predict disease-free survival in stage III colon cancer and enable nomogram-based risk stratification. [PDF]

Front Oncol
Xu J, Qu F, Wang X, Liang S, Jiang D, Wang Z.   +5 more
europepmc   +1 more source

Can Disease-Free Survival Be a Surrogate for Overall Survival for Drug Approvals? [PDF]

JNCI Journal of the National Cancer Institute, 2004
openaire   +1 more source