Results 111 to 120 of about 10,142,751 (308)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Multivariate analysis for disease-free survival and overall survival.
, 2015 Multivariate analysis for disease-free survival and overall survival.
Huanwen Wu (697595) +7 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Overall survival and disease-free survival in endometrial cancer: prognostic factors in 276 patients
OncoTargets and Therapy, 2013 The aim of the study reported here was to assess the disease-free survival and overall survival of patients with endometrial cancer and to determine independent factors affecting the prognosis.This was a retrospective study of a single-center clinical series of 276 patients (mean age 64 years) with histologically confirmed cancer of the corpus uteri ...
Tejerizo-GarcÃa,Ãlvaro +6 more
openaire +4 more sources
, 2015 (A) Disease Free Survival curve for the total of CRC patients. (B) Overall Survival curve for the total of CRC patients. (C) Disease Free Survival curve for the +2960 14-bp INDEL SNP according to the dominant model.
Elena De Mattia (833429) +15 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Frontiers in OncologyBackgroundIncreased PD-1 expression on CD8+ T cells is considered as a hallmark for T-cell exhaustion, and is thought to be related to the prognosis of cancer patients.
Zhiyong Wan +8 more
doaj +1 more source
Disease-Free Survival is a Promising Surrogate for Overall Survival in Colorectal Cancer Studies [PDF]
JNCI: Journal of the National Cancer Institute, 2021 openaire +2 more sources
Scientific criticisms of the comparison of exponential survival and disease-free survival curves.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1988 Scientific criticism when analyzed in depth, appears to be as exacting as ethical criticism of statistics relating to adjuvant therapy comparative trial results, based on survival or on length of first remission. The heterogeneity of a population in which an exponential curve represents survival or period of disease-free survival (OFS) raises the issue
G, Mathé, M, Eriguchi
openaire +1 more source
Cancer Medicine, 2017 AbstractThe goal of this study is to establish a method for predicting overall survival (OS) and disease‐free survival (DFS) in breast cancer patients after surgical operation. The gene expression profiles of cancer tissues from the patients, who underwent complete surgical resection of breast cancer and were subsequently monitored for postoperative ...
Daichi Shigemizu +8 more
openaire +2 more sources