Results 91 to 100 of about 7,550,908 (268)
Nihon Naika Gakkai Zasshi, 1999 最近10年間にチャネル蛋白の遺伝子異常に基づく疾患が続々と同定され,チャネル病(channelopathy)と呼ばれるようになっている.チャネルが神経・筋の刺激伝導の主役であることを反映して,チャネル病には神経・筋疾患が多いが,心臓のQT延長症候群や腎の水・電解質疾患も含まれる.分子生物学により臨床と基礎の垣根が一挙に消失することがあるが,チャネル病はその典型例である.チャネル病解析から,障害されている遺伝子に基づく疾患分類の大切さが浮かび上がってきた.また遺伝子変異の種類から,コードされているチャネル蛋白の溝造・機能共関についての示唆を得ることもできた.治療に対する試みは始ったばかりであるが,今後の進展が期待できる.
openaire +2 more sources
Misperception of Body Weight After Childhood Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Misperception of body weight can negatively impact the weight management efforts of childhood cancer survivors (CCSs). Both being overweight or underweight are associated with chronic health conditions commonly observed in CCS; therefore, accurate weight perception is critical for reducing long‐term health risks.
Fabiën N. Belle +8 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver +25 more
wiley +1 more source
Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations
Pediatric Blood &Cancer, EarlyView.ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan +18 more
wiley +1 more source
Immunoglobulin Depletion and Recovery Following Blinatumomab in Infants With KMT2A‐Rearranged ALL
Pediatric Blood &Cancer, EarlyView.ABSTRACT Adding blinatumomab to standard chemotherapy for infants with KMT2A‐rearranged acute B‐cell lymphoblastic leukemia (KMT2A‐r B‐ALL) improves outcomes. Although blinatumomab impairs immunoglobulin G (lgG) production, increasing infection susceptibility, IgG recovery remains poorly understood.
Miguel Vieira Martins +14 more
wiley +1 more source
Journal of Political EcologyEstimates that 60% of emerging infectious diseases are zoonotic in origin, combined with recent high-profile zoonotic outbreaks like the COVID-19 pandemic, have the world scrambling to understand, predict, and prevent zoonotic disease risks and outbreaks.
Ekaterina Gladkova, Francis Masse
doaj +2 more sources
Infectious diseases: meningococcal disease
Western Journal of Medicine, 2000 This article comes from Clinical Evidence (2000;3:350-357), a new resource for clinicians produced jointly by the BMJ Publishing Group and theAmerican College of Physicians—American Society of Internal Medicine.Clinical Evidence is an extensively peer-reviewed publication that summarizes the best available evidence on the effects of common clinical ...
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger +8 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source