Results 111 to 120 of about 26,337,030 (428)
Neuroinflammation in Preclinical Alzheimer's Disease: A Review of Current Evidence [PDF]
, 2018 The pathology of sporadic Alzheimer’s disease (AD) may be present at mid-life and precede the prodromal and clinical dementia syndromes associated with the disorder by decades.
Raymont, Vanessa +2 more
core +2 more sources
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
DomainScope: A disease network based on protein domain connections [PDF]
arXiv, 2019 Protein domains are highly conserved functional units of proteins. Because they carry functionally significant information, the majority of the coding disease variants are located on domains. Additionally, domains are specific units of the proteins that can be targeted for drug delivery purposes.
arxiv
A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer's Disease Data. [PDF]
, 2019 There is well-documented evidence of brain network differences between individuals with Alzheimer's disease (AD) and healthy controls (HC). To date, imaging studies investigating brain networks in these populations have typically been cross-sectional ...
Alzheimer’s Disease Neuroimaging Initiative +5 more
core +2 more sources
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Current Opinion in Pediatrics, 1990 We now have more than 30 years of solid, scientific research about Lyme disease, a relatively common, vector-borne illness in parts of the United States and of Europe. Although there is still widespread misunderstanding of and misinformation about the disease among the lay public, its clinical manifestations as well as how to diagnose and to treat it ...
openaire +9 more sources
Pravljične pošasti in pošastno v oglasih
Fairy Tale Monsters and the Monstrous in Advertising
Studia Mythologica Slavica, 2014 In folklore, evil has always been represented by monsters in various shapes and sizes. Through cultures, the demonic world has been the fearsome counterpart of the good, the two worlds coexisting in a constant struggle.
Simona Klaus
doaj +1 more source
Correlation-based Discovery of Disease Patterns for Syndromic Surveillance [PDF]
arXiv, 2021 Early outbreak detection is a key aspect in the containment of infectious diseases, as it enables the identification and isolation of infected individuals before the disease can spread to a larger population. Instead of detecting unexpected increases of infections by monitoring confirmed cases, syndromic surveillance aims at the detection of cases with
arxiv