Results 111 to 120 of about 10,094,215 (299)

Spatializing zoonotic disease dynamics from a political ecology perspective: Reconceptualizing spillover as structure

Journal of Political Ecology
Estimates that 60% of emerging infectious diseases are zoonotic in origin, combined with recent high-profile zoonotic outbreaks like the COVID-19 pandemic, have the world scrambling to understand, predict, and prevent zoonotic disease risks and outbreaks.
Ekaterina Gladkova, Francis Masse
doaj   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Main Causes of Bat Mortality Obtained Through Admission to Rescue Centres

Diversity
Bats have decreasing population trends around the world, and knowledge on the causes for this decline is the first step to improving conservation and management strategies to restore their populations.
Alfonso Balmori-de la Puente, Alfonso Balmori   +1 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials [PDF]

, 2016
Li‐Tzu Wang, Chiao-Hsuan Ting, Ming‐Shyen Yen, Ko‐Jiunn Liu, Huey‐Kang Sytwu, Kenneth K. Wu, B. Linju Yen   +6 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Using X-ray images and deep learning for automated detection of coronavirus disease

, 2020
Khalid El Asnaoui, Youness Chawki
openalex   +2 more sources

Predictors of disease progression in HIV infection: a review [PDF]

, 2007
Simone E Langford, Jintanat Ananworanich, David A. Cooper   +2 more
openalex   +1 more source