Results 111 to 120 of about 27,443,428 (376)
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Lessons about Causes and Management of an Ebola Outbreak
Folia Medica, 2017 Ebola virus disease (EVD) is one of the deadliest viral diseases. It is characterized by a high mortality rate due to the lack of effective and safe treatments or vaccines and its ability to spread at an unstoppable pace.
Elargoubi Aida +5 more
doaj +1 more source
Is Alzheimer Disease a Disease? [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2019 Problem:Alzheimer disease (AD) is defined as “an irreversible, progressive brain disorder that slowly destroys memory and thinking skills” (National Institute on Aging) and is pathologically characterized by abnormal deposition of neurofibrillary tangles and amyloid plaques.
openaire +2 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Alzheimer's Disease Prediction Using Longitudinal and Heterogeneous Magnetic Resonance Imaging
, 2018 Recent evidence has shown that structural magnetic resonance imaging (MRI) is an effective tool for Alzheimer's disease (AD) prediction and diagnosis. While traditional MRI-based diagnosis uses images acquired at a single time point, a longitudinal study
Dai, Xiaowu +1 more
core
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
, 2017 Dupuytren\u27s disease (DD) is a chronic condition in which fibrosis of tissue beneath the palm of the hand occurs. Causes and mechanisms of this disease\u27s development are still not entirely understood.
Pinckney, Leah C.
core +1 more source
Modeling the long term dynamics of pre-vaccination pertussis
, 2012 The dynamics of strongly immunizing childhood infections is still not well understood. Although reports of successful modeling of several incidence data records can be found in the literature, the key determinants of the observed temporal patterns have ...
Ana Nunes +4 more
core +1 more source
External review and validation of the Swedish national inpatient register
BMC Public Health, 2011 Background The Swedish National Inpatient Register (IPR), also called the Hospital Discharge Register, is a principal source of data for numerous research projects. The IPR is part of the National Patient Register.
Kim Jeong-Lim +7 more
doaj +1 more source