Results 181 to 190 of about 27,443,428 (376)
Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea +9 morewiley +1 more sourceDetecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda +12 morewiley +1 more sourceEvaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin +6 morewiley +1 more sourceData‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo +8 morewiley +1 more sourceGlobal, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
The Lancet, 2020 Boris Caroline A Andrew S Mari Amir Molla Oladimeji M Mo Bikbov Purcell Levey Smith Abdoli Abebe Adebayo Af, B. Bikbov, Caroline A. Purcell, A. Levey, Mari Smith, Amir Abdoli, Molla Abebe, O. Adebayo, M. Afarideh, Sachin Agarwal, Marcela Agudelo-Botero, E. Ahmadian, Z. Al-Aly, V. Alipour, A. Almasi-Hashiani, Rajaa Al-Raddadi, N. Alvis-Guzmán, S. Amini, Tudorel Andrei, C. Andrei, Zewudu Andualem, Mina Anjomshoa, J. Arabloo, A. Ashagre, Daniel Asmelash, Z. Ataro, Maha Moh’d Wahbi Atout, M. Ayanore, A. Badawi, A. Bakhtiari, S. Ballew, A. Balouchi, Maciej Banach, S. Barquera, Sanjay Basu, Mulat Tirfie Bayih, Neeraj Bedi, A. Bello, I. Benseñor, Ali Bijani, A. Boloor, A. Borzì, L. Cámera, J. Carrero, F. Carvalho, Franz Castro, F. Catalá-López, Alex R. Chang, K. Chin, Sheng-Chia Chung, Massimo Cirillo, Ewerton Cousin, L. Dandona, R. Dandona, A. Daryani, R. Das Gupta, F. M. Demeke, Gebre Teklemariam Demoz, Desilu Mahari Desta, H. Do, B. Duncan, A. Eftekhari, A. Esteghamati, S. S. Fatima, João Fernandes, E. Fernandes, F. Fischer, M. Freitas, M. Gad, Gebreamlak Gebremedhn Gebremeskel, B. M. Gebresillassie, Birhanu Geta, M. Ghafourifard, A. Ghajar, N. Ghith, P. Gill, I. Ginawi, R. Gupta, N. Hafezi-Nejad, Arvin Haj-Mirzaian, A. Haj-Mirzaian, Ninuk Hariyani, M. Hasan, Milad Hasankhani, A. Hasanzadeh, H. Y. Hassen, Simon Iain Hay, B. Heidari, C. Herteliu, C. L. Hoang, M. Hosseini, M. Hostiuc, S. Irvani, S. Islam, Nader Jafari Balalami, S. James, S. Jassal, V. Jha, J. Jonas, F. Joukar, J. Jozwiak, Alia Kabir, Amaha Kahsay, A. Kasaeian, T. Kassa, Hagazi Gebremedhin Kassaye, Yousef S. Khader, Rovshan Khalilov, E. Khan, M. S. Khan, Y. Khang, A. Kisa, C. Kovesdy, B. Kuate Defo, G. Kumar, A. Larsson, L. Lim, Alan D. Lopez, P. Lotufo, A. Majeed, R. Malekzadeh, Winfried März, Anthony Masaka, H. Meheretu, T. Miazgowski, Andreea Mirica, E. Mirrakhimov, P. Mithra, B. Moazen, D. K. Mohammad, R. Mohammadpourhodki, S. Mohammed, A. Mokdad, Linda Morales, Ilais Moreno Velásquez, Seyyed Meysam Mousavi, S. Mukhopadhyay, J. Nachega, Girish N. Nadkarni, J. R. Nansseu, G. Natarajan, J. Nazari, B. Neal, R. Negoi, C. Nguyen, Rajan Nikbakhsh, J. Noubiap, C. Nowak, A. Olagunju, Alberto Ortiz, M. Owolabi, R. Palladino, M. Pathak, H. Poustchi, S. Prakash, N. Prasad, A. Rafiei, S. Raju, K. Ramezanzadeh, S. Rawaf, D. Rawaf, Lal B Rawal, R. Reiner, A. Rezapour, D. Ribeiro, L. Roever, D. Rothenbacher, Godfrey M. Rwegerera, Seyedmohammad Saadatagah, Saeed Safari, B. Sahle, Hosni Salem, J. Sanabria, I. Santos, Arash Sarveazad, M. Sawhney, E. Schaeffner, M.I. Schmidt, A. Schutte, S. Sepanlou, M. Shaikh, Z. Sharafi, M. Sharif, Amrollah Sharifi, D. Silva, Jasvinder A. Singh, N. P. Singh, M. M. Sisay, A. Soheili, I. Sutradhar, B. Teklehaimanot, B. E. Tesfay, Getnet Teshome, J. Thakur, M. Tonelli, Khanh B. Tran, B. Tran, Candide Tran Ngoc, I. Ullah, Pascual Valdez, S. Varughese, T. Vos, L. G. Vu, Yasir Waheed, A. Werdecker, H. F. Wolde, A. Wondmieneh, Sarah Wulf Hanson, Tomohide Yamada, Yigizie Yeshaw, N. Yonemoto, H. Yusefzadeh, Z. Zaidi, Leila Zaki, S. Zaman, N. Zamora, A. Zarghi, Kaleab Alemayehu Zewdie, J. Ärnlöv, J. Coresh, N. Perico, G. Remuzzi, C. Murray, T. Vos +223 moresemanticscholar +1 more source
