Results 201 to 210 of about 27,151,543 (398)

Fibrocystic Disease of the Pancreas [PDF]

, 1949
W. J. Matheson
openalex   +1 more source

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

Hepatology, 2018
N. Chalasani, Z. Younossi, J. Lavine, M. Charlton, K. Cusi, M. Rinella, S. Harrison, E. Brunt, A. Sanyal   +8 more
semanticscholar   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Editorial: Extra-Oral Taste Receptors: Function, Disease and Evolution

Frontiers in Physiology, 2020
Ronghua ZhuGe, Eugeni Roura, Maik Behrens   +2 more
doaj   +1 more source

Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

The Lancet, 2020
Boris Caroline A Andrew S Mari Amir Molla Oladimeji M Mo Bikbov Purcell Levey Smith Abdoli Abebe Adebayo Af, B. Bikbov, Caroline A. Purcell, A. Levey, Mari Smith, Amir Abdoli, Molla Abebe, O. Adebayo, M. Afarideh, Sachin Agarwal, Marcela Agudelo-Botero, E. Ahmadian, Z. Al-Aly, V. Alipour, A. Almasi-Hashiani, Rajaa Al-Raddadi, N. Alvis-Guzmán, S. Amini, Tudorel Andrei, C. Andrei, Zewudu Andualem, Mina Anjomshoa, J. Arabloo, A. Ashagre, Daniel Asmelash, Z. Ataro, Maha Moh’d Wahbi Atout, M. Ayanore, A. Badawi, A. Bakhtiari, S. Ballew, A. Balouchi, Maciej Banach, S. Barquera, Sanjay Basu, Mulat Tirfie Bayih, Neeraj Bedi, A. Bello, I. Benseñor, Ali Bijani, A. Boloor, A. Borzì, L. Cámera, J. Carrero, F. Carvalho, Franz Castro, F. Catalá-López, Alex R. Chang, K. Chin, Sheng-Chia Chung, Massimo Cirillo, Ewerton Cousin, L. Dandona, R. Dandona, A. Daryani, R. Das Gupta, F. M. Demeke, Gebre Teklemariam Demoz, Desilu Mahari Desta, H. Do, B. Duncan, A. Eftekhari, A. Esteghamati, S. S. Fatima, João Fernandes, E. Fernandes, F. Fischer, M. Freitas, M. Gad, Gebreamlak Gebremedhn Gebremeskel, B. M. Gebresillassie, Birhanu Geta, M. Ghafourifard, A. Ghajar, N. Ghith, P. Gill, I. Ginawi, R. Gupta, N. Hafezi-Nejad, Arvin Haj-Mirzaian, A. Haj-Mirzaian, Ninuk Hariyani, M. Hasan, Milad Hasankhani, A. Hasanzadeh, H. Y. Hassen, Simon Iain Hay, B. Heidari, C. Herteliu, C. L. Hoang, M. Hosseini, M. Hostiuc, S. Irvani, S. Islam, Nader Jafari Balalami, S. James, S. Jassal, V. Jha, J. Jonas, F. Joukar, J. Jozwiak, Alia Kabir, Amaha Kahsay, A. Kasaeian, T. Kassa, Hagazi Gebremedhin Kassaye, Yousef S. Khader, Rovshan Khalilov, E. Khan, M. S. Khan, Y. Khang, A. Kisa, C. Kovesdy, B. Kuate Defo, G. Kumar, A. Larsson, L. Lim, Alan D. Lopez, P. Lotufo, A. Majeed, R. Malekzadeh, Winfried März, Anthony Masaka, H. Meheretu, T. Miazgowski, Andreea Mirica, E. Mirrakhimov, P. Mithra, B. Moazen, D. K. Mohammad, R. Mohammadpourhodki, S. Mohammed, A. Mokdad, Linda Morales, Ilais Moreno Velásquez, Seyyed Meysam Mousavi, S. Mukhopadhyay, J. Nachega, Girish N. Nadkarni, J. R. Nansseu, G. Natarajan, J. Nazari, B. Neal, R. Negoi, C. Nguyen, Rajan Nikbakhsh, J. Noubiap, C. Nowak, A. Olagunju, Alberto Ortiz, M. Owolabi, R. Palladino, M. Pathak, H. Poustchi, S. Prakash, N. Prasad, A. Rafiei, S. Raju, K. Ramezanzadeh, S. Rawaf, D. Rawaf, Lal B Rawal, R. Reiner, A. Rezapour, D. Ribeiro, L. Roever, D. Rothenbacher, Godfrey M. Rwegerera, Seyedmohammad Saadatagah, Saeed Safari, B. Sahle, Hosni Salem, J. Sanabria, I. Santos, A. Sarveazad, M. Sawhney, E. Schaeffner, M.I. Schmidt, A. Schutte, S. Sepanlou, M. Shaikh, Z. Sharafi, M. Sharif, Amrollah Sharifi, D. Silva, Jasvinder A. Singh, N. P. Singh, M. M. Sisay, A. Soheili, I. Sutradhar, B. Teklehaimanot, B. E. Tesfay, Getnet Teshome, J. Thakur, M. Tonelli, Khanh B. Tran, B. Tran, Candide Tran Ngoc, I. Ullah, Pascual Valdez, S. Varughese, T. Vos, L. G. Vu, Yasir Waheed, A. Werdecker, H. F. Wolde, A. Wondmieneh, Sarah Wulf Hanson, Tomohide Yamada, Yigizie Yeshaw, N. Yonemoto, H. Yusefzadeh, Z. Zaidi, Leila Zaki, S. Zaman, N. Zamora, A. Zarghi, Kaleab Alemayehu Zewdie, J. Ärnlöv, J. Coresh, N. Perico, G. Remuzzi, C. Murray, T. Vos   +223 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source