Results 201 to 210 of about 10,094,215 (299)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Differences in Anti-αvβ6 Integrin Antibody Expression between U.S. and Japanese Cohorts in Inflammatory Bowel Disease. [PDF]

Inflamm Bowel Dis
Kakuta Y, Li D, Debbas P, Okazaki S, Sawahashi M, Yang S, Iwaki H, Okamoto D, Nagai H, Shimoyama Y, Naito T, Moroi R, Kuroha M, Shiga H, Kinouchi Y, Shirai T, Fujii H, McGovern DPB, Masamune A.   +18 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Body roundness index and mortality risk in chronic diseases: a national prospective longitudinal study in China. [PDF]

Aging Clin Exp Res
Sun X, Deng Q, Li Z, Lin C, Song G, Chen S, Zheng Y.   +6 more
europepmc   +1 more source

Access of vulnerable groups to antiretroviral therapy among persons in care for HIV disease in the United States. HCSUS Consortium. HIV Cost and Services Utilization Study. [PDF]

, 2000
Ronald Andersen, Samuel A. Bozzette, Martin F. Shapiro, Patti St. Clair, Stephen Morton, Stephen Crystal, Dana P. Goldman, Neil S. Wenger, Allen L. Gifford, Arleen Leibowitz, Steven M. Asch, Sandra Berry, Terry T. Nakazono, Kevin C. Heslin, William E. Cunningham   +14 more
openalex  

Ribosomal Proteins and Human Diseases: Pathogenesis, Molecular Mechanisms, and Therapeutic Implications

, 2014
Wei Wang, Subhasree Nag, Xu Zhang, Ming‐Hai Wang, Hui Wang, Jianwei Zhou, Ruiwen Zhang   +6 more
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Development and validation of the manual disease activity score (MDAS) for rheumatoid arthritis. [PDF]

Rheumatol Immunol Res
Salim B, Nasim A, Jahan S, Perveen S, Samreen S, Gul H, Afzal A, Rizwan NUA, Ahmed M, Yasmin S.   +9 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Occupational balance, quality of life, occupational performance, and disease-related factors in people with multiple sclerosis: A case-control study. [PDF]

Aust Occup Ther J
Ortiz-Rubio A, Lexell EM, Håkansson C, Navas-Otero A.   +3 more
europepmc   +1 more source