Results 91 to 100 of about 5,753,304 (312)

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

The Metabolic Implications of Glucocorticoids in a High-Fat Diet Setting and the Counter-Effects of Exercise

Metabolites, 2016
Glucocorticoids (GCs) are steroid hormones, naturally produced by activation of the hypothalamic-pituitary-adrenal (HPA) axis, that mediate the immune and metabolic systems. Synthetic GCs are used to treat a number of inflammatory conditions and diseases
Emily C. Dunford, Michael C. Riddell
doaj   +1 more source

High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT): A multicenter randomized clinical trial [PDF]

, 2016
Objectives: To determine whether prolonged intensive disease-modifying antirheumatic drug (DMARD) treatment (PRINT) leads to high remission and low relapse rates in patients with severe rheumatoid arthritis (RA).
Chen, Li-Na, Deng, Xue-Rong, Fang, Yong-Fei, Gu, Fei, Hao, Yan-Jie, He, Jing, Keystone, Edward, Li, Ru, Li, Xing-Fu, Li, Zhan-Guo, Liu, Hua-Xiang, Liu, Xiang-Yuan, Liu, Yi, McInnes, Iain B., Su, Yin, Sun, Ling-Yun, Xue, Yu, Zhang, Zhuo-Li, Zhao, Cheng, Zhao, Jin-Xia, Zhao, Yi, Zhou, Wei, Zhu, Ping, Zou, He-Jian, Zou, Qing-Hua   +24 more
core   +3 more sources

Incidence and Risk Factors of Serious Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia: A CYP‐C Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers, Chantal Éthier, Caroline Laverdière, Nathalie Alos, Thai Hoa Tran, Marie‐Claude Pelland‐Marcotte   +5 more
wiley   +1 more source

Effectiveness of a tailored forest package of interventions, including topical repellents, in reducing malaria incidence in Myanmar

Malaria Journal
Background In Myanmar, progress towards malaria elimination has stagnated in some areas requiring deployment of new tools and approaches to accelerate malaria elimination.
Kyawt Mon Win, John E. Gimnig, Nay Yi Yi Linn, Feliciano Monti, Nu Nu Khin, William A. Hawley, Jimee Hwang, Ryan E. Wiegand, Ersin Topcuoglu, Alexander Moran, Khin Lin, Hsu Thadar, Aye Aye Myint, Kyaw Myint Tun   +13 more
doaj   +1 more source

Comparison of venous and pooled capillary hemoglobin levels for the detection of anemia among adolescent girls

Frontiers in Nutrition
IntroductionBlood source is a known preanalytical factor affecting hemoglobin (Hb) concentrations, and there is evidence that capillary and venous blood may yield disparate Hb levels and anemia prevalence.
Mica Jenkins, Mica Jenkins, Esi Foriwa Amoaful, Mutala Abdulai, Veronica Quartey, Ruth Situma, Porbilla Ofosu-Apea, Jevaise Aballo, Maku E. Demuyakor, Lucas Gosdin, Carine Mapango, Maria Elena D. Jefferds, O. Yaw Addo, O. Yaw Addo, O. Yaw Addo   +14 more
doaj   +1 more source

Improving the Evaluation and Management of Transfusion‐Related Iron Overload in Children, Adolescents, and Young Adults Following Cancer Treatment or Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell, Allison Close, Guoli Zhou, Troy C. Quigg   +3 more
wiley   +1 more source

Detection of emotions in Parkinson's disease using higher order spectral features from brain's electrical activity [PDF]

, 2014
Non-motor symptoms in Parkinson's disease (PD) involving cognition and emotion have been progressively receiving more attention in recent times. Electroencephalogram (EEG) signals, being an activity of central nervous system, can reflect the underlying ...
Aftanas, Ariatti, Balconi, Balli, Baumgartner, Beck, Bouchard, Bowers, Bradley, Brown, Christianini, Chua, Clark, Cohen, Dara, Davidson, Fahn, Folstein, Gao, Garrido-Vásquez, Gray, Gross, Hadjidimitriou, Hamdi, Han, Hoehn, Hsu, Janvin, Jeong, Jerritta, Kawamura, Kenneth Sundaraj, Kessous, Khairiyah Mohamad, Kim, Kim, Klimesch, Kober, Lang, Lawrence, Lima, M. Murugappan, McCarthy, Mikels, Miller, Mohd Iqbal Omar, Mohr, Muller, Murugappan, Nikias, Norlinah Mohamed Ibrahim, Oathes, Oldfield, Park, Paulmann, Pell, Petrantonakis, Pillon, Péron, R. Palaniappan, R. Yuvaraj, Redondo, Roschke, Sammler, Savitt, Schmidt, Schröder, Shen, Sprengelmeyer, Stama, Suzuki, Tessitore, Wang, Wang, Wieser, Wieser, Yuvaraj   +76 more
core   +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack, Wan‐Chun Chang, Miguel Cordova‐Delgado, Spencer J. Anderson, Jessica N. Trueman, Erika N. Scott, Catrina M. Loucks, Shahrad R. Rassekh, Gabriella S. S. Groeneweg, Michelle Higginson, Kathy Li, Fudan Miao, Derek Yau, Donna Johnston, Mounira Ibrahim, Maja Krajinovic, Thai Hoa Tran, Jessica Tewfik, Jean‐François Bussières, Thaïna‐Rafi Jean‐Baptiste, Denis Lebel, Lucie Pecheux, Bina Gyawali, Gregory Guilcher, Gesche Riabowol, Geert ’t Jong, Michelle Staub, Geoff Cuvelier, Kathleen Felton, Sara Khalaj, Michael Rieder, Awatif Abuzgaia, Tamorah Lewis, Himal Ghimire, Paul Nathan, Kerry Goralski, Ketan Kulkarni, Zara Forbrigger, Colin J. D. Ross, Bruce C. Carleton   +39 more
wiley   +1 more source

A method for calculating BMI z-scores and percentiles above the 95th percentile of the CDC growth charts

Annals of Human Biology, 2020
Background The 2000 CDC growth charts are based on national data collected between 1963 and 1994 and include a set of selected percentiles between the 3rd and 97th and LMS parameters that can be used to obtain other percentiles and associated z-scores ...
Rong Wei, Cynthia L. Ogden, Van L. Parsons, David S. Freedman, Craig M. Hales   +4 more
doaj   +1 more source