Results 161 to 170 of about 5,766,482 (313)

Disease activity and mental health symptoms in axial spondyloarthritis: concordant or discordant? [PDF]

Rheumatology (Oxford)
Zhao SS, Webers C, Nikiphorou E, van der Heijde D, Braun J, Kiltz U, Ramiro S, Boonen A.   +7 more
europepmc   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Fungal-Bacterial Dysbiosis in IBD: Microbial Biomarkers of Disease Activity. [PDF]

Microbiologyopen
Arribas-Rodríguez E, García-Pizarro M, De Prado Á, Santiago-Carretero M, Hernández M, Jiménez BV, García-Alonso J, Barrio J, Eiros JM, Arranz E, Bernardo D, Fernández-Salazar L, Cuesta-Sancho S.   +12 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Defining Bath Ankylosing Spondylitis Disease Activity Index Cut-off Values for Disease Activity States in a Multinational European Cohort of Patients With Axial Spondyloarthritis. [PDF]

ACR Open Rheumatol
Georgiadis S, Ørnbjerg LM, Michelsen B, Kvien TK, Shoae Kazemi M, Závada J, Pavelka K, Glintborg B, Loft AG, Reich A, Regierer AC, Rodrigues AM, Santos MJ, Rutanen J, Kuusalo L, Ciurea A, Nissen MJ, Gudbjornsson B, Pálsson Ó, Rotar Ž, Perdan Pirkmajer K, Di Giuseppe D, Østergaard M, Hetland ML.   +23 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Perioperative disease activity and metabolic optimization in spinal Paget's disease. [PDF]

Brain Spine
Abudayeh A, Fishchenko I.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Effect of Everyday Discrimination on Systemic Lupus Erythematosus Disease Activity and Mental Health Outcomes. [PDF]

J Rheumatol
Benson KRK, Becerril A, Park J, Plantinga L, Yazdany J, Dall'Era M, Katz PP.   +6 more
europepmc   +1 more source

Association of histologic disease activity with progression of nonalcoholic fatty liver disease [PDF]

, 2019
Brundt, Elizabeth M, et al,, Kleiner, David E   +2 more
core   +1 more source