Results 101 to 110 of about 14,610,755 (282)
Egyptian Rheumatology and RehabilitationBackground Rheumatoid arthritis (RA) is a systemic autoimmune chronic inflammatory disease, causing progressive disability. Methotrexate (MTX) is the gold standard drug treatment for RA.
Hagar Ahmed Tawfik Kabil +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Causes of arthritis flares in chikungunya arthritis cases grouped by disease activity Score-28 compared using Kruskal-Wallis analysis.
Juan Carlos Perez Hernandez (18189679) +35 more
core +1 more source
Impact of rheumatoid arthritis on the quality of life and its relation to disease activity
Egyptian Rheumatology and Rehabilitation, 2019 Background Quality of life (QOL) is a multidimensional concept that is used to describe the individuals’ perceptions, satisfaction, and evaluation of different areas of their own lives, such as physical health and functioning, psychological and emotional
Samar H Goma +2 more
doaj +1 more source
Journal of Experimental and Integrative Medicine, 2012 Objective: Various factors are known to determine the disease activity in patients with rheumatoid arthritis (RA). The ‘simplified disease activity’ index (SDAI) is new tool of measurement of disease activity. The present study was designed to assess validity of SDAI using C-reactive protein (CRP) titer in comparison to ‘disease activity score in 28 ...
Ehab Alchy +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
State indicator report on physical activity, 2010 [PDF]
"The State Indicator Report on Physical Activity, 2010, provides information on physical activity behavior and policy and environmental supports within each state.
National Center for Chronic Disease Prevention and Health Promotion (U.S.) Division of Nutrition, Physical Activity and Obesity.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Fibromyalgia Syndrome and Vitiligo: A Novel Association
The Turkish Journal of Gastroenterology, 2018 Objectives: This study aims to assess the relationship between fibromyalgia syndrome (FMS) and vitiligo in Iraqi patients and evaluate the predictors of this relationship, if present.
Oula S. KHUDHAIR +2 more
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source