Results 231 to 240 of about 2,559,167 (303)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

A plasma-based DNA test for quantification of disease burden in acute myeloid leukemia patients undergoing bone marrow transplantation. [PDF]

Proc Natl Acad Sci U S A
Wang Y, Xie J, Pasca S, Popoli M, Ptak J, Dobbyn L, Silliman N, Paul S, Jones RJ, Levis MJ, Curtis SD, Douville C, Shams C, Guo MZ, Mo S, Gocke CD, Malek SN, Bollard CM, Bettegowda C, Kinzler KW, Vogelstein B, Papadopoulos N, Gondek LP.   +22 more
europepmc   +1 more source

Change in body mass index and disease burden among people with obesity and multiple long-term conditions. [PDF]

Diabetes Obes Metab
Khunti K, Mourer A, Capucci S, Wilkinson L, Andersen KK, Tahrani AA, Morgen CS.   +6 more
europepmc   +1 more source

Clinical Status, Treatment, and Disease Burden of Generalised Myasthenia Gravis in the Asia-Pacific. [PDF]

Neurol Ther
Webb T, Kasahara-Kiritani M, Herr K, Yu D, Lee B, Barlow S, Birija SL, Conyers J, Connolly H, Gibson G, Hatchell N, Ringland C, Hong YH.   +12 more
europepmc   +1 more source

Sickle cell disease in Jharkhand: A registry-based evaluation of disease burden and healthcare needs. [PDF]

Indian J Med Res
Prasad A, Kumari A, Kumar K, Chaudhuri PK, Shakya S, Chauhan G, Kumari S, Kisku AV, Kumar A, Guria RT.   +9 more
europepmc   +1 more source

The rare disease burden: a multidimensional challenge. [PDF]

Acta Biochim Pol
Cyske Z, Radzanowska-Alenowicz E, Rintz E, Gaffke L, Pierzynowska K.   +4 more
europepmc   +1 more source