Results 221 to 230 of about 2,559,167 (303)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Impact of exposure frequency on disease burden of the common cold - A mathematical modeling perspective. [PDF]

PLoS One
Gerdes S, Rank M, Glauche I, Roeder I.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Systematic Literature Reviews on the Disease Burden of Pediatric Psoriasis. [PDF]

Dermatol Ther (Heidelb)
Sanchez SZ, Tran T, Garcia A, Telukuntla V, Pillai S, Horgan J, Deignan C.   +6 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Infectious disease burden and surveillance challenges in Jordan and Palestine: a systematic review and meta-analysis. [PDF]

Front Digit Health
Badran EF, Rayyan A, Al Jaberi M, Azzam M, Ramadan R, Khader Y, Alqutob R, Bakri FG, Qasrawi R, Yacoub T, Sharaqa A, Fraihat N, Trigui H, Sokhn E, Tayyem R, Musa E, Kong JD.   +16 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Global Disease Burden of Traumatic Joint Dislocation from 1990 to 2021 and its prediction to 2045. [PDF]

Commun Med (Lond)
Huang J, Tang H, Chen J, Liang R, Jia S, Jiao Z, Li L, Zhang X, Su J, Deng Z, Lin J, Zhang X.   +11 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Association of Obesity Severity With Cardiometabolic and Renal Disease Burden in the United States. [PDF]

Obesity (Silver Spring)
Corpodean F, Kachmar M, Yang S, Heymsfield SB, Katzmarzyk PT, Schauer PR, Cook MW, Albaugh VL.   +7 more
europepmc   +1 more source