Results 201 to 210 of about 1,348,267 (265)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Disease burden of asbestos-related diseases in China (1990-2023) based on GBD estimates: A call for stronger labor protection laws. [PDF]

PLoS One
An D, Shi Z, Zhang C, Song S, Wang L, Li H.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Reframing disease burden: validation of DALY-per-case as a per-diagnosis severity metric. [PDF]

Popul Health Metr
Freihat O.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Sex-Based Differences in Disease Burden and Phenotype in CADASIL: A Multicenter Study of 368 Korean Patients. [PDF]

Neurol Genet
Kim JG, Choi JC, Kang CH, Oh JH, Lee JS, Kang JH, Byeon S, Lim JS, Kim BJ, Kim H, Suh CH, Heo SH, Woo HG, Nam HS, Lee BC, Yu KH, Oh MS, Lee M, Kim CK, Oh K, Kang SH, Lee KJ, Han JH, Kim YS, Kim HY, Kim HJ, Bae HJ, Han MK, Kang J, Kim BJ, Kim JY, Lee SH, Jung KH, Sohn SI, Hong JH, Park H, Kwon JH, Kim WJ, Shin DI, Yum KS, Chae HY, Sung SM, Seo SW, Kim JP, Jung JM, Lee K, Park TH, Park SS, Choi JK, Park MS, Kim JT, Choi KH, Cha JK, Kim DH, Yoon BA, Lee SJ, Kim JG, Kim DH, Kim DE, Gwak DS, Kim C, Lee SH, Lee J, Kwon DH, Kang K, Park KY, Jeong HB, Park CY, Cho YJ, Hong KS, Park HK.   +70 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Disease burden of Streptococcus pneumoniae and Neisseria meningitidis meningitis in children and adolescents: A population-based study. [PDF]

Medicine (Baltimore)
Zhang J, Qin L, Liu N, Zhang F, Jiang Q.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Differences in disease burden between neuromyelitis optica spectrum disorder and multiple sclerosis in South China. [PDF]

Mult Scler J Exp Transl Clin
Huang X, Feng H, Li J, Fan Y, Zeng J.
europepmc   +1 more source