Results 181 to 190 of about 2,559,167 (303)

Disease burden of interstitial lung disease and pulmonary sarcoidosis from 1992 to 2021 and prediction of future disease burden trend in China. [PDF]

J Thorac Dis
Xie Z, Du Y, Zhou L, Xiong W, Zhang M, Xiang T, Yang Z.   +6 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Underrepresentation of Women in COPD Pharmacologic Trials Relative to Disease Burden: A Systematic Review and Meta-Analysis. [PDF]

Int J Chron Obstruct Pulmon Dis
Umer M, Jagra AS, Al Seidi J, Ahmad A, Touza M, Emehinola O, Surani S, Hanif FM.   +7 more
europepmc   +1 more source

The burdens of digestive diseases [PDF]

Nature Reviews Gastroenterology & Hepatology, 2009
openaire   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Reframing disease burden: validation of DALY-per-case as a per-diagnosis severity metric. [PDF]

Popul Health Metr
Freihat O.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Sex-Based Differences in Disease Burden and Phenotype in CADASIL: A Multicenter Study of 368 Korean Patients. [PDF]

Neurol Genet
Kim JG, Choi JC, Kang CH, Oh JH, Lee JS, Kang JH, Byeon S, Lim JS, Kim BJ, Kim H, Suh CH, Heo SH, Woo HG, Nam HS, Lee BC, Yu KH, Oh MS, Lee M, Kim CK, Oh K, Kang SH, Lee KJ, Han JH, Kim YS, Kim HY, Kim HJ, Bae HJ, Han MK, Kang J, Kim BJ, Kim JY, Lee SH, Jung KH, Sohn SI, Hong JH, Park H, Kwon JH, Kim WJ, Shin DI, Yum KS, Chae HY, Sung SM, Seo SW, Kim JP, Jung JM, Lee K, Park TH, Park SS, Choi JK, Park MS, Kim JT, Choi KH, Cha JK, Kim DH, Yoon BA, Lee SJ, Kim JG, Kim DH, Kim DE, Gwak DS, Kim C, Lee SH, Lee J, Kwon DH, Kang K, Park KY, Jeong HB, Park CY, Cho YJ, Hong KS, Park HK.   +70 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source