Results 171 to 180 of about 1,348,267 (265)

Discrepancies in loneliness and social isolation predict cognitive impairment through chronic disease burden. [PDF]

Brain Behav Immun Health
Cintron DW, Yoneda T, Wang H, Graham EK, Ong AD.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Trends and subnational variation in maternal disease burden in China from 1990 to 2021. [PDF]

Chin Med J (Engl)
Zou Y, Asihaer Y, Li M, He H, Khattab NM, Elshishiney G, Qi J, Yin P, Wang L, Zhou M, Hu Y.   +10 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Higher disease burden and greater small fibre impairment in women with painful diabetic neuropathy. [PDF]

Pain Rep
Sloan G, Selvarajah D, Smith J, Pallai S, Greig M, Goonoo MS, Cash T, Abera MA, Caunt S, Wilkinson ID, Tesfaye S.   +10 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Carotid Duplex-Derived Markers Across Angiographic Coronary Artery Disease Burden: A Pandemic-Era Real-World Cohort Study. [PDF]

J Clin Med
Aras T, Grigorian A, Tayeh M, Aswad A, Sharkawy M, Almuzakki Z, Dorweiler B, Cernaianu G, Majd P.   +8 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Renal Disease Burden in Prurigo Nodularis: A Systematic Review and Meta-Analysis. [PDF]

Int J Dermatol
Chalupczak N, Bourand N, Woo D, Chovatiya R.   +3 more
europepmc   +1 more source