Results 91 to 100 of about 4,341,243 (262)

Surveillance of West Nile virus infections in humans and animals in Europe, monthly report – data submitted up to 3 September 2025

EFSA Journal
Epidemiological summary In 2025, and as of 3 September 2025, 9 countries in Europe reported 652 locally acquired1 human cases of WNV infection with known place of infection.
European Centre for Disease Prevention and Control (ECDC), European Food Safety Authority (EFSA)   +1 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Surveillance of West Nile virus infections in humans and animals in Europe, monthly report – data submitted up to 6 August 2025

EFSA Journal
Epidemiological summary In 2025, and as of 6 August 2025, 6 countries in Europe reported 202 locally acquired1 human cases of WNV infection with known place of infection. The earliest and latest date of onset were respectively on 2 June 2025 and 2 August
European Centre for Disease Prevention and Control (ECDC), European Food Safety Authority (EFSA)   +1 more
doaj   +1 more source

Clinical pathway for diagnosis and treatment of new diagnosed multiple myeloma in Guangxi

Guangxi Yike Daxue xuebao
Multiple myeloma, an incurable clonal plasma cell dysplasia, is the second most common hematological malignancy. Standardized diagnosis and treatment are crucial for prolonging the survival of myeloma patients and improving the quality of their lives ...
The Control Center of Medical Quality of Guangxi Hematology, Guangxi Plasma Cell Disease Collaboration   +1 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Surveillance of West Nile virus infections in humans and animals in Europe, monthly report

EFSA Journal
Epidemiological summary In 2025, and as of 2 July 2025, no countries in Europe reported any locally acquired1 human cases of WNV infection with known place of infection. In the previous five years, the first locally acquired cases of the WNV transmission
European Centre for Disease Prevention and Control (ECDC), European Food Safety Authority (EFSA)   +1 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Surveillance of West Nile virus infections in humans and animals in Europe, monthly report – data submitted up to 3 October 2025

EFSA Journal
Epidemiological summary In 2025, and as of 3 October 2025, 13 countries in Europe reported 989 locally acquired1 human cases of WNV infection with known place of infection.
European Centre for Disease Prevention and Control (ECDC), European Food Safety Authority (EFSA)
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The European Union One Health 2024 Zoonoses Report

EFSA Journal
This report by the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring and surveillance activities carried out in 2024 in 27 Member States (MSs), the United Kingdom ...
European Food Safety Authority (EFSA) | European Centre for Disease Prevention and Control (ECDC)
doaj   +1 more source