Results 131 to 140 of about 141,910 (306)

Winners and losers from Johne’s disease eradication from the Scottish dairy herd: a Markov-Chain simulation

In this paper, we evaluated the welfare effects of a hypothetical programme of Johne's disease eradication from the Scottish dairy herd on different stakeholders in the domestic milk market. We undertook the evaluation using a Markov-Chain simulation and
Weldegebriel, Habtu T., Gunn, George J., Stott, Alistair W.   +2 more
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Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Global challenges and solutions to achieving and sustaining measles and rubella elimination

Revista Panamericana de Salud Pública
Measles and rubella have long been recognized as priorities for disease prevention because of their devastating consequences for child health; hence, all World Health Organization (WHO) regions currently have a goal to eliminate measles and four out of ...
Natasha S. Crowcroft, Anna A. Minta, Sebastien Antoni, Lee Lee Ho, William Perea, Mick N. Mulders, Anindya Sekhar Bose, Aaron Wallace, Diana Chang Blanc, Patrick M. O’Connor   +9 more
doaj   +1 more source

Polio eradication strategy 2022\u20132026 : delivering on a promise [Spanish]

Polio eradication strategy 2022\u20132026 : delivering on a promise [Spanish]9789240035362-spa ...

core  

Mosquitoes: The Long-term Effects of Malaria Eradication in India [PDF]

We examine the effects of malaria on educational attainment and income by exploiting geographic variation in malaria prevalence in India prior to a nationwide eradication program in the 1950s.
Winnie Fung, Monica Singhal, Tom Vogl, David Cutler, Michael Kremer   +4 more
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Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Bovine tuberculosis (bTB) eradication, brushtail possum control, and causal inference

Wildlife Society Bulletin
Bovine tuberculosis (bTB) in livestock (cattle and farmed deer) is the focus of an in‐progress eradication program in New Zealand. The program includes intensive brushtail possum population control as this species is a bTB host and could compromise ...
Jim Hone
doaj   +1 more source

The Economic Effects of Malaria Eradication: Evidence from an Intervention in Uganda [PDF]

This study evaluates the economic consequences of a malaria eradication campaign in the southwestern Ugandan district of Kigezi. The project was a joint venture between the WHO and Uganda's Ministry of Health, designed to test for the first time the ...
Farshad Farzadfar, Jeremy Barofsky, Claire Chase, Tobenna Anekwe   +3 more
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