Results 111 to 120 of about 141,910 (306)
Advanced Science, EarlyView.The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao +8 more
wiley +1 more source
Advanced Science, EarlyView.An immunoregulatory hydrogel based on sodium ascorbate (SA)‐accelerated gelation and in situ self‐mineralization is prepared here. Such a hydrogel is constructed by mixing benzaldehyde‐ and cyanoacetate‐functionalized dextran with silver nitrate (AgNO3) and SA, enabling the ultrafast solidification and in situ self‐mineralization of silver ...
Xiaoya Ding +4 more
wiley +1 more source
Advanced Science, EarlyView.A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo +5 more
wiley +1 more source
Global Polio Eradication progress 2003
The Global Polio Eradication Initiative achieved strong progress in 2003. By the end of 2003, only 6 countries in the world were still polio-endemic, the lowest number ever: Nigeria, India, Pakistan, Niger, Afghanistan and Egypt.WHO/Polio/04 ...
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Measles Eradication; Recommendations From a Meeting Cosponsored by the World Health Organization, the Pan American Health Organization, and CDC [PDF]
"Recent successes in interrupting indigenous transmission of measles virus in the Americas and in the United Kingdom prompted the World Health Organization (WHO), Pan American Health Organization (PAHO), and CDC to convene a meeting in July, 1996 to ...
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CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors
Advanced Science, EarlyView.Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen +12 more
wiley +1 more source
Polio eradication strategy 2022\u20132026 : delivering on a promise [Chinese]
Polio eradication strategy 2022\u20132026 : delivering on a promise [Chinese]9789240035386-chi ...
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Global Polio Eradication progress 1999 [PDF]
The global initiative to eradicate polio by the end of 2000 has become the largest public health initiative in history, and is spearheaded by WHO, Rotary International, U.S. Centers for Disease Control and Prevention, and UNICEF.
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Advanced Science, EarlyView.This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim +8 more
wiley +1 more source
Polio eradication strategy 2022\u20132026 : delivering on a promise [Russian]
Polio eradication strategy 2022\u20132026 : delivering on a promise [Russian]9789240035348-rus ...
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