Results 101 to 110 of about 141,910 (306)

Assessing progress and challenges towards malaria elimination in Kampong Speu, Cambodia: analysis of Plasmodium vivax and mixed infections, 2019–2023

Western Pacific Surveillance and Response
Malaria is a life-threatening but preventable disease caused by Plasmodium parasites transmitted through bites of infected female Anopheles mosquitoes.
Kanha Ly, Sophanith Ung, Maria Concepcion Roces, Dysoley Lek, Po Ly   +4 more
doaj   +1 more source

Global Polio Eradication progress 2000

The Global Polio Eradication Initiative, the largest public health initiative in history, is on track to certify the world polio-free in 2005. Polio cases have declined by 99% since the launch of the Initiative in 1988, from 350 000 to less than 3500 ...

core  

Global polio eradication : reaching every last child [PDF]

Polio is a crippling and potentially deadly infectious disease. The virus spreads from person to person and can invade an infected person\u2019s spinal cord, causing life-long paralysis or in rare instances, death.

core  

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Differential Effect of Helicobacter pylori Eradication on Time-Trends in Brady/Hypokinesia and Rigidity in Idiopathic Parkinsonism

, 2010
Background: We examine the effect of eradicating Helicobacter in idiopathic parkinsonism (IP). Marked deterioration, where eradication-therapy failed, prompted an interim report in the first 20 probands to reach de-blinding.
Bjarnason, IT, Lawson, Andrew J., Dobbs, RJ, Dobbs, R. John, Lucy Harbin, Ibrahim, Mohammad A. A.; id_orcid, Peterson, Dale W., Ibrahim, MA, J. Malcolm Plant, Smee, Cori, Daniel Leckstroem, Plant, JM, Charlett, A, Harbin, Lucy, Lawson, AJ, Bowthorpe, James, Ingvar T. Bjarnason, Mohammad A. A. Ibrahim, Price, AB, André Charlett, Clive Weller, Smee, C, Dobbs, Sylvia M., James Bowthorpe, Dale W. Peterson, Letley, Darren, Leckstroem, Daniel, Charlett, Andre, Weller, C, Andrew J. Lawson, Dobbs, SM, R. John Dobbs, Harbin, L, Letley, D, Price, Ashley B., Bjarnason, Ingvar T., Peterson, DW, Norman L. Oxlade, Weller, Clive, Bowthorpe, J, Ashley B. Price, Oxlade, NL, Oxlade, Norman L., Sylvia M. Dobbs, Plant, J. Malcolm, Darren Letley, Leckstroem, D, Cori Smee   +47 more
core   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Ibrutinib and venetoclax target distinct subpopulations of CLL cells: implication for residual disease eradication. [PDF]

Blood Cancer J, 2021
Lu P, Wang S, Franzen CA, Venkataraman G, McClure R, Li L, Wu W, Niu N, Sukhanova M, Pei J, Baldwin DA, Nejati R, Wasik MA, Khan N, Tu Y, Gao J, Chen Y, Ma S, Larson RA, Wang YL.   +19 more
europepmc   +1 more source

Global Polio Eradication Initiative; strategic plan, 2001-2005

Extraordinary progress has been made toward global eradication of poliomyelitis. Only 30 countries were considered endemic at the end of 1999, down from 50 in 1998.

core  

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Contributing factors to declining vaccination campaign quality and resurgence of polio cases in Quetta block, Pakistan: a five-year analysis (2020–2024)

Frontiers in Public Health
IntroductionImplementation of supplementary immunization activities (SIAs) delivering oral poliovirus vaccine (OPV) to children under 5 years of age is a key strategy for interruption of poliovirus transmission.
Ehsan Larik, Ehsan Larik, Aftab Kakar, Aftab Kakar, Aftab Kakar, Kifayat Ullah, Kifayat Ullah, Tamkeen Ghafoor, Tamkeen Ghafoor, Abdul Sami Khan, Abdul Sami Khan, Gohar Ali Shahbaz, Abdul Raziq, Chukwuma Mbaeyi   +13 more
doaj   +1 more source