Results 101 to 110 of about 284,123 (305)

Deliberate Extinction: Whether to Destroy the Last Smallpox Virus [PDF]

, 2004
The target problem to be examined is smallpox. Specifically, what should we (the United States and the entire world) now do with the last known residual samples of the virus that causes this uniquely horrific disease?
Koplow, David A.
core   +1 more source

Prevalence of BoHV-1 seropositive and BVD virus positive bulls on Irish dairy farms and associations between bull purchase and herd status [PDF]

, 2015
peer-reviewedBackground BVD and IBR are contagious viral diseases highly prevalent in Irish cattle. Despite their significant reproductive and economic impact very little is known about the BVD and IBR status of stock bulls (a bull used ...
Martinez-Ibeas, Ana M, McClure, Jennifer, Power, C., Sayers, Riona   +3 more
core   +2 more sources

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Global Public Goods and Global Health [PDF]

, 2012
The repair rate on electron beam welded diaphragm hasn’t been at the desired level at Siemens SIT for several years. An improvement program the past five years has reduce the repair rate from 60% to 12-15% but the goal of 5% repair rate hasn’t been met ...
Gartner, David
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Viral hepatitis: a review of global prevalence and research progress toward elimination

Zhongguo gonggong weisheng
Viral hepatitis is one of the leading infectious diseases contributing to the global increase in mortality and posing a serious threat to global public health.
Wenqi HUANG, Huiyan WEN, Jiaxin LI, Miao XU, Congling QIU, Fangfang ZENG, Dan LIU, Xujing LIANG, Xiaofeng LIANG   +8 more
doaj   +1 more source

Learning from the past: the future of malaria in Africa [PDF]

, 2009
This repository item contains a single issue of Issues in Brief, a series of policy briefs that began publishing in 2008 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future.
Graboyes, Melissa
core   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Eradication Therapy For Ulcer Disease

Актуальные проблемы теоретической и клинической медицины, 2022
The article presents the results of the eradication therapy of HP factor in the treatment of patients with gastric ulcer and duodenal ...
А. Ө. Үсенова, Л. Ж. Оспанова, А. Е. Құрманова, С. Р. Кенжебай, Ш. С. Кушкинбаева, К. Е. Жумабек   +5 more
doaj  

Reply to: Rethinking disease eradication: putting countries first. [PDF]

Int Health, 2021
Hopkins DR, Ijaz K, Weiss A, Roy SL, Ross DA.   +4 more
europepmc   +1 more source