Results 91 to 100 of about 284,123 (305)

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Recurrence of intestinal metaplasia and early neoplasia after endoscopic eradication therapy for Barrett’s esophagus: A systematic review and meta-analysis [PDF]

, 2017
Background Conflicting data exist with regard to recurrence rates of intestinal metaplasia (IM) and dysplasia after achieving complete eradication of intestinal metaplasia (CE-IM) in Barrett’s esophagus (BE) patients.
Cinnor, Birtukan, Das, Ananya, Early, Dayna S, Edmundowicz, Steven A, Fujii-Lau, Larissa L, Gaddam, Srinivas, Komanduri, Srinadh, Kushnir, Vladimir, Mullady, Daniel, Muthusamy, V. Raman, Shaheen, Nicholas, Simon, Violette C, Wani, Sachin, Wilson, Robert   +13 more
core   +2 more sources

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori [PDF]

, 2015
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection.
Adebisi, Adebisi, Adeola O. Adebisi, Ahuja, Akiyama, Bai, Bajpai, Barbara R. Conway, Batchelor, Bazzoli, Boddupalli, Cammarota, Castro, Chun, Desai, Dunn, Dupuy, Erah, Erah, Ernst, Gal, Georgopoulos, Gåserød, Higuchi, Hixson, Iijima, Ikeda, Ishak, Kawahara, Khanvilkar, Kohri, Korsmeyer, Lee, Lehmann, Malfertheiner, Miyazaki, Moore, Murata, Murray, Najib, Nakagawa, Nayak, Norris, Park, Pasparakis, Pereira, Peter R. Laity, Peterson, Rajinikanth, Romero, Rothenbacher, Singh, Smrdel, Stops, Suerbaum, Suzuki, Umamaheshwari, Varum, Whitehead, Østberg   +59 more
core   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Randomized Controlled Trial Comparing Standard Triple and Sequential Regimens for Helicobacter pylori Eradication

Central Asian Journal of Medical Sciences, 2016
Objectives: The aim of this study was to compare effectiveness of sequential therapy to the standard triple therapy to eradicate Helicobacter pylori (H. pylori) in Mongolia.
Byambajav Tsogt-Ochir, Oyuntsetseg Khasag, Bira Namdag, Erdenetsogt Dungubat, Choijamts Gotov, Sarantuya Tserenchimed, Enkhtsetseg Altangerel   +6 more
doaj   +1 more source

An Optimal Surveillance Measure Against Foot-and-Mouth Disease in the United States [PDF]

Surveillance programs on farms and in the local environment provide an essential protection against the importation and spread of exotic diseases. Combined with border quarantine measures, these programs protect both consumers and producers from major ...
Che, Tuong Nhu, Kompas, Tom, van Ha, Pham   +2 more
core   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Cost-effectiveness and return on investment of hepatitis C virus elimination in China: A modelling study [PDF]

Clinical and Molecular Hepatology
Background/Aims The World Health Organization set the goal of eliminating hepatitis C virus (HCV) by 2030, with 80% and 65% reductions in HCV incidence and mortality rates, respectively.
Meiyu Wu, Jing Ma, Xuehong Wang, Sini Li, Chongqing Tan, Ouyang Xie, Andong Li, Aaron G Lim, Xiaomin Wan   +8 more
doaj   +1 more source

Sugarcane smut: the political economy of biosecurity [PDF]

The discovery of sugarcane smut in one Queensland cane region, in June 2006, triggered a clear-cut biosecurity response aimed at containment and eradication.
Antony, George
core   +1 more source