Results 151 to 160 of about 123,413 (291)

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Advanced Science, EarlyView.
This carrier‐free, esterase‐responsive nanoaggregate integrates a mitochondria‐targeting photosensitizer with a non‐nucleotide STING agonist to achieve localized photoactivation and immune reprogramming. ICyM2 remodels tumor stroma, induces potent immunogenic cell death, and triggers intratumoral STING activation, collectively revitalizing the ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
wiley   +1 more source

Early minimal residual disease eradication in light chain amyloidosis generates deeper and faster cardiac response. [PDF]

Clin Exp Med
Xu T, Li J, Yang Y, Wang W, Zhou C, Wang P, Yu C, Liu P.   +7 more
europepmc   +1 more source

Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. Results from the randomized clinical trial 08-09 of the Cooperative Acute Lymphoblastic Leukemia Study Group

, 2021
Gabriele Escherich, Udo zur Stadt, Arndt Borkhardt, Dagmar Dilloo, Jörg Faber, Tobias Feuchtinger, Thomas Imschweiler, Norbert Jorch, Arnulf Pekrun, Irene Schmid, Franziska Schramm, Michael Spohn, Martin Zimmermann, Martin A. Horstmann   +13 more
openalex   +2 more sources

Guinea worm disease nears eradication [PDF]

The Lancet Infectious Diseases, 2016
openaire   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Advancing Health Security and Disease Eradication Through Peace and Health: A Mali Case Study. [PDF]

Health Secur
Sanders AM, Warman M, Deycard F, Goodman J, Klein A, Unterwegner K, Sangare B, Moussa S, George S, Chica IP, Coulibaly CO, Saye M, Jensen KA, Weiss AJ, Ijaz K.   +14 more
europepmc   +1 more source

Displaced populations due to humanitarian emergencies and its impact on global eradication and elimination of vaccine-preventable diseases [PDF]

, 2016
Eugene Lam, Michael R. Diaz, Allen Gidraf Kahindo Maina, Muireann Brennan   +3 more
openalex   +1 more source

Will AI Enable Disease Eradication? A Critical Look at the Digital Frontier of Global Health

, 2022
www.rasitdinc.com
openalex   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Use of Spatial Epidemiology in Neglected Tropical Diseases Control, Elimination and Eradication

Kingford Chimfwembe, Christopher Simoonga, Hikabasa Halwindi, Rockiner Kenneth Simoonga   +3 more
openalex   +2 more sources