Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son +3 more
wiley +1 more source
Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER‐TBI Observational Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Reserve refers to the brain's ability to maintain function after an injury and strongly relates to traumatic brain injury (TBI) outcomes. This study examined (1) whether associations between pre‐injury reserve proxies and outcomes differed across injury severity categories, and (2) whether the impact of injury severity varied across ...
Natascha Ekdahl +6 more
wiley +1 more source
U.S. Cancer Statistics: Highlights from 2016 Incidence
U.S. Cancer Statistics: Highlights from 2016 Incidence: U.S. Cancer Statistics Data Briefs, No. 8: June 2019. Each year, the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI) produce updated U.S.
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Gut microbiota and pathobiont exposure influences disease incidence in non-obese diabetic mice. [PDF]
Front MicrobiolRussell AL +5 more
europepmc +1 more source
Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui +10 more
wiley +1 more source
Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal +10 more
wiley +1 more source
Incidence of malignant melanoma of the skin\u2013United States, 2009\u20132018
In 2018, a total of 83,996 new cases of melanoma were reported in the United States: 49,547 among males and 34,449 among females. The incidence rate was 22.0 per 100,000 standard population, 27.9 per 100,000 males, and 17.7 per 100,000 females.Invasive ...
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Longitudinal Study of Frailty Phenotype in Relation to Chronic Kidney Disease Incidence. [PDF]
J Cachexia Sarcopenia MuscleRuan YX +13 more
europepmc +1 more source
Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph +5 more
wiley +1 more source
Prostate Cancer Incidence by Stage at Diagnosis, United States\u20142001 122019
In 2019, a total of 224,733 new cases of prostate cancer were reported in the United States. The incidence rate was 112 per 100,000 males. Most cases of prostate cancer (70%) were diagnosed at the local stage.Aside from non-melanoma skin cancer, prostate
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