The Origin of the Variola Virus [PDF]
Viruses, 2015 The question of the origin of smallpox, one of the major menaces to humankind, is a constant concern for the scientific community. Smallpox is caused by the agent referred to as the variola virus (VARV), which belongs to the genus Orthopoxvirus.
Igor V. Babkin, Irina N. Babkina
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Research with variola virus after smallpox eradication: Development of a mouse model for variola virus infection. [PDF]
PLoS Pathogens, 2021 Funder: Wellcome ...
Bernard Moss, Geoffrey L Smith
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Re-Assembly and Analysis of an Ancient Variola Virus Genome [PDF]
Viruses, 2017 We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with
Chad Smithson, Jacob Imbery, Chris Upton
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Prediction of steps in the evolution of variola virus host range. [PDF]
PLoS ONE, 2014 Variola virus, the agent of smallpox, has a severely restricted host range (humans) but a devastatingly high mortality rate. Although smallpox has been eradicated by a World Health Organization vaccination program, knowledge of the evolutionary processes
Chad Smithson +3 more
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Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines [PDF]
mBio, 2023 Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then.
Aline R. V. Souza +4 more
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A Multiplex PCR/LDR Assay for the Simultaneous Identification of Category A Infectious Pathogens: Agents of Viral Hemorrhagic Fever and Variola Virus. [PDF]
PLoS ONE, 2015 CDC designated category A infectious agents pose a major risk to national security and require special action for public health preparedness. They include viruses that cause viral hemorrhagic fever (VHF) syndrome as well as variola virus, the agent of ...
Sanchita Das +12 more
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Neutralization Determinants on Poxviruses
Viruses, 2023 Smallpox was a highly contagious disease caused by the variola virus. The disease affected millions of people over thousands of years and variola virus ranked as one of the deadliest viruses in human history. The complete eradication of smallpox in 1980,
Vernuccio Riccardo, Guardado-Calvo Pablo
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Development of a High-Content Orthopoxvirus Infectivity and Neutralization Assays. [PDF]
PLoS ONE, 2015 Currently, a number of assays measure Orthopoxvirus neutralization with serum from individuals, vaccinated against smallpox. In addition to the traditional plaque reduction neutralization test (PRNT), newer higher throughput assays are based on ...
Irina Gates +5 more
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Viruela del simio: ¿estamos frente a un riesgo de pandemia?. Historia de un viejo conocido
Interdisciplinary Journal of Epidemiology and Public Health, 2022 La viruela del simio es una zoonosis de etiología viral causada por virus de la viruela del simio o Monkeypox virus (MPXV) (por su nombre en inglés). MPXV es un virus de ADN de doble cadena de la familia Poxviridae, a la cual pertenece el virus Variola ...
Richar Jose Gomez De la Rosa +1 more
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Functional epitopes and neutralizing antibodies of vaccinia virus
Frontiers in Microbiology, 2023 Smallpox is an infectious disease caused by the variola virus, and it has a high mortality rate. Historically it has broken out in many countries and it was a great threat to human health.
Fenghao Peng +12 more
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