The Origin of the Variola Virus [PDF]
Viruses, 2015 The question of the origin of smallpox, one of the major menaces to humankind, is a constant concern for the scientific community. Smallpox is caused by the agent referred to as the variola virus (VARV), which belongs to the genus Orthopoxvirus.
Igor Babkin, Igor V Babkin
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Re-Assembly and Analysis of an Ancient Variola Virus Genome [PDF]
Viruses, 2017 We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with
Chris Upton, Chad Smithson, Jacob Imbery
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Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines [PDF]
mBio, 2023 Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then.
Aline R. V. Souza +4 more
doaj +2 more sources
Evidence of Long-Distance Aerial Convection of Variola Virus and Implications for Disease Control [PDF]
Viruses, 2019 Two distinct phenomena of airborne transmission of variola virus (smallpox) were described in the pre-eradication era—direct respiratory transmission, and a unique phenomenon of transmission over greater distances, referred to as “aerial ...
Chandini Raina MacIntyre +4 more
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Prediction of steps in the evolution of variola virus host range. [PDF]
PLoS ONE, 2014 Variola virus, the agent of smallpox, has a severely restricted host range (humans) but a devastatingly high mortality rate. Although smallpox has been eradicated by a World Health Organization vaccination program, knowledge of the evolutionary processes
Chad Smithson +3 more
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In Silico Studies of Potential Selective Inhibitors of Thymidylate Kinase from Variola virus [PDF]
Pharmaceuticals, 2021 Continuing the work developed by our research group, in the present manuscript, we performed a theoretical study of 10 new structures derived from the antivirals cidofovir and ribavirin, as inhibitor prototypes for the enzyme thymidylate kinase from ...
Danielle R. Garcia +7 more
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HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus [PDF]
Cell ReportsSummary: Histone deacetylases (HDACs) regulate gene expression and innate immunity. Previously, we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a restriction factor for VACV and herpes simplex virus type 1.
Yongxu Lu +6 more
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Research with variola virus after smallpox eradication: Development of a mouse model for variola virus infection. [PDF]
PLoS Pathogens, 2021 Bernard Moss, Geoffrey L Smith
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EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses [PDF]
Journal of Immunology Research, 2015 Concerns that variola viruses might be used as bioweapons have renewed the interest in developing new and safer smallpox vaccines. Variola virus genomes are now widely available, allowing computational characterization of the entire T-cell epitome and ...
Magdalena Molero-Abraham +4 more
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Are we there yet? The smallpox research agenda using variola virus. [PDF]
PLoS Pathogens, 2014 Inger K Damon +2 more
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