Results 1 to 10 of about 84,745 (238)
Emerging Infectious Diseases, 2010 When the World Health Organization declared smallpox eradicated in 1979, smallpox vaccination was discontinued worldwide. Although cessation of smallpox vaccination is well justified, given the risks associated with complications from the vaccine, lack of vaccination nevertheless creates a growing population of persons now susceptible to infection by a
Richard C. Condit
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Pharmaceutics, 2022 Oncolytic viruses have emerged as a promising modality in cancer treatment given their high synergy with highly efficient immune checkpoint inhibitors. However, their potency is limited by their rapid in vivo clearance.
Kaelan T. Samoranos +9 more
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Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses
Frontiers in Immunology, 2020 We conducted a large genome-wide association study (GWAS) of the immune responses to primary smallpox vaccination in a combined cohort of 1,653 subjects.
Richard B. Kennedy +8 more
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Ophthalmic Features and Implications of Poxviruses: Lessons from Clinical and Basic Research
Microorganisms, 2022 Amidst the ongoing monkeypox outbreak, global awareness has been directed towards the prevention of viral transmission and case management, with the World Health Organization declaring the outbreak a public health emergency of international concern ...
Tolulope Fashina +4 more
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Clinical Infectious Diseases, 2003 The resumption of smallpox vaccination for health care workers and other first responders has raised concern about the occurrence of complications in people with immunodeficiency disorders, including those infected with human immunodeficiency virus.
Mike, Bray, Mary E, Wright
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The Rise and Fall of Modern Plagues
Molecular Frontiers Journal, 2020 Millennia separate smallpox, the oldest pandemic, and COVID-19, the newest. Both calamities arose from an opportunistic virus amid human crowding. A vaccine for smallpox existed since the late 18th century, but it took worldwide public health strategy to
G. Terry Sharrer
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Role of early viral surface antigens in cellular immune response to vaccinia virus [PDF]
, 1976 Infection of mice with the vaccinia virus strain WR, Elstree or DIs, a conditional lethal mutant of vaccinia virus, resulted in the generation of vaccinia virus-specific sensitized cytolytic T lymphocytes (CTL).
Ertl, H., Koszinowski, Ulrich H.
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Interactions between vaccinia virus and sensitized macrophages in vitro [PDF]
, 1975 The action of peritoneal exudate cells (PEC) from normal and vaccinia virus infected mice on infectious vaccinia virus particles was investigatedin vitro. PEC from immune mice showed a significantly higher infectivity titre reduction (virus clearance, VC)
A. V. Boand +25 more
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Molecular Therapy: Oncolytics, 2023 Tumor-specific overexpression of receptors enables a variety of targeted cancer therapies, exemplified by peptide-receptor radiotherapy (PRRT) for somatostatin receptor (SSTR)-positive neuroendocrine tumors.
Kathryn Ottolino-Perry +9 more
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Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]
, 2010 Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H +15 more
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