Results 1 to 10 of about 7,324 (160)
An Update of Orthopoxvirus Molecular Evolution [PDF]
Viruses, 2022 Although variola virus (VARV) has been eradicated through widespread vaccination, other orthopoxviruses pathogenic for humans circulate in nature. Recently, new orthopoxviruses, including some able to infect humans, have been found and their complete ...
Nina V Tikunova
exaly +5 more sources
Pox-AbDab: the orthopoxvirus antibody database [PDF]
Frontiers in ImmunologyIn August 2024, the World Health Organization declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in three years, emphasising the need for continued studies into its microbiology and potential ...
Henriette L. Capel +4 more
doaj +5 more sources
Evolution of the orthopoxvirus core genome
Virus Research, 2023 Orthopoxviruses comprise several relevant pathogens, including the causative agent of smallpox and monkeypox virus. Analysis of orthopoxvirus genome evolution mainly focused on gene gains/losses. We instead analyzed core genes, which are conserved in all orthopoxviruses.
Cristian Molteni +2 more
exaly +5 more sources
Emerging Microbes and Infections, 2023 The worldwide outbreak of the monkeypox virus (MPXV) has become a “Public Health Emergency of International Concern” (PHEIC). Severe monkeypox virus infection can be fatal, however, effective therapeutic methods are yet to be developed.
Jiayin Chen, Yuhao Lin
exaly +3 more sources
A retrospective study of the orthopoxvirus molecular evolution
Infection, Genetics and Evolution, 2012 The data on the structure of conserved genes of the Old and New World orthopoxviruses and unclassified Yoka poxvirus were used for a Bayesian dating of their independent evolution. This reconstruction estimates the time when an orthopoxvirus ancestor was transferred to the North American continent as approximately 50 thousand years ago (TYA) and allows
Igor V Babkin
exaly +3 more sources
Therapeutic Vaccines and Antibodies for Treatment of Orthopoxvirus Infections [PDF]
Viruses, 2010 Despite the eradication of smallpox several decades ago, variola and monkeypox viruses still have the potential to become significant threats to public health. The current licensed live vaccinia virus-based smallpox vaccine is extremely effective as a prophylactic vaccine to prevent orthopoxvirus infections, but because of safety issues, it is no ...
Yuhong Xiao, Stuart N Isaacs
exaly +4 more sources
Monkeypox: A Mini-Review on the Globally Emerging Orthopoxvirus
International Journal of Environmental Research and Public Health, 2022 Monkeypox is a zoonotic infectious disease belonging to the orthopoxvirus family that has predominantly occurred in West and Central Africa since it was initially discovered in 1958. In May 2022, a global outbreak of monkeypox began to occur on an international scale, with case numbers still rising as this review is being written.
Bara' Abdallah Alshurman +2 more
exaly +3 more sources
Vaccinia and Monkeypox Virus-Neutralizing Antibodies in People Living with HIV: A Serological Study in a Orthopoxvirus-Endemic, Low-Income Region in Brazil [PDF]
PathogensCo-infections of Orthopoxviruses (OPVs), such as vaccinia virus (VACV) and monkeypox virus (MPXV), and the human immunodeficiency virus (HIV) can be associated with severe outcomes.
Thyago José Silva +10 more
doaj +2 more sources
Skin lesions caused by Orthopoxvirus, cowpox - case report from Poland
Journal of Education, Health and Sport, 2021 Background:Despite the elimination of smallpox, other orthopoxviruses, including cowpox virus, still infect humans. Wild rodents are its natural reservoir.
Konrad Kania +4 more
doaj +1 more source
Priming stroma with a vitamin D analog to optimize viroimmunotherapy for pancreatic cancer
Molecular Therapy: Oncolytics, 2022 Pancreatic cancer resistance to immunotherapies is partly due to deficits in tumor-infiltrating immune cells and stromal density. Combination therapies that modify stroma and recruit immune cells are needed.
Sang-In Kim +13 more
doaj +1 more source