Results 1 to 10 of about 11,329 (224)

An Update of Orthopoxvirus Molecular Evolution [PDF]

Viruses, 2022
Although variola virus (VARV) has been eradicated through widespread vaccination, other orthopoxviruses pathogenic for humans circulate in nature. Recently, new orthopoxviruses, including some able to infect humans, have been found and their complete ...
Igor V. Babkin, Irina N. Babkina, Nina V. Tikunova   +2 more
exaly   +5 more sources

Three neutralizing mAbs induced by MPXV A29L protein recognizing different epitopes act synergistically against orthopoxvirus

Emerging Microbes and Infections, 2023
The worldwide outbreak of the monkeypox virus (MPXV) has become a “Public Health Emergency of International Concern” (PHEIC). Severe monkeypox virus infection can be fatal, however, effective therapeutic methods are yet to be developed.
Yushan Jiang, Delin Li, Chenguang Shen
exaly   +3 more sources

Pox-AbDab: the orthopoxvirus antibody database [PDF]

Frontiers in Immunology
In August 2024, the World Health Organization declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in three years, emphasising the need for continued studies into its microbiology and potential ...
Henriette L. Capel, Eric Ji Da Wang, Benjamin H. Williams, Charlotte M. Deane, Matthew I. J. Raybould   +4 more
doaj   +2 more sources

Vaccinia and Monkeypox Virus-Neutralizing Antibodies in People Living with HIV: A Serological Study in a Orthopoxvirus-Endemic, Low-Income Region in Brazil [PDF]

Pathogens
Co-infections of Orthopoxviruses (OPVs), such as vaccinia virus (VACV) and monkeypox virus (MPXV), and the human immunodeficiency virus (HIV) can be associated with severe outcomes.
Thyago José Silva, Ana Gabriella Stoffella-Dutra, Victor Lacerda Gripp, Pollyana R. C. Gorgens, Iago José da Silva Domingos, Pedro Henrique Bastos e Silva, Bruna Caroline Chaves-Garcia, Erna Geessien Kroon, Etel Rocha-Vieira, Giliane de Souza Trindade, Danilo Bretas de Oliveira   +10 more
doaj   +2 more sources

Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics. [PDF]

MedComm (2020)
This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutics. The primary objective of this review is to advance the understanding of MPXV and facilitate the development of more effective diagnostic methods ...
Yan Y, Sun Y, Sun G, Niu C, Zhao X, Zhao M, Liu T, Zhang S, Zhai H, Liu A, Yu S, Pan S, Zhong W, Zhang Y, Li S.   +14 more
europepmc   +2 more sources

Operationalizing a Hub-and-Spoke Telemedicine Model for Mpox Surveillance in a High-Alert, Zero-Prevalence Setting: An Observational Study, Real-World Experience From Iran. [PDF]

Interdiscip Perspect Infect Dis
Background The global monkeypox (Mpox) outbreak prompted heightened surveillance in regions with significant travel links. Fars Province, Iran, implemented a structured telemedicine response to manage patients presenting with Mpox‐like symptoms. Objectives This study aimed to describe and evaluate the impact of a tiered, hub‐and‐spoke telemedicine ...
Eilami O, Eilami N, Heiran A, Nejat M, Sayadi M.   +4 more
europepmc   +2 more sources

Skin lesions caused by Orthopoxvirus, cowpox - case report from Poland

Journal of Education, Health and Sport, 2021
Background:Despite the elimination of smallpox, other orthopoxviruses, including cowpox virus, still infect humans. Wild rodents are its natural reservoir.
Konrad Kania, Maria Kalicka, Tomasz Korzec, Przemyslaw Raczkiewicz, Monika Kuc   +4 more
doaj   +1 more source

Priming stroma with a vitamin D analog to optimize viroimmunotherapy for pancreatic cancer

Molecular Therapy: Oncolytics, 2022
Pancreatic cancer resistance to immunotherapies is partly due to deficits in tumor-infiltrating immune cells and stromal density. Combination therapies that modify stroma and recruit immune cells are needed.
Sang-In Kim, Shyambabu Chaurasiya, Venkatesh Sivanandam, Seonah Kang, Anthony K. Park, Jianming Lu, Annie Yang, Zhifang Zhang, Isabella A. Bagdasarian, Yanghee Woo, Joshua T. Morgan, Zhirong Yin, Yuman Fong, Susanne G. Warner   +13 more
doaj   +1 more source

Human Monkeypox without Viral Prodrome or Sexual Exposure, California, USA, 2022

Emerging Infectious Diseases, 2022
We report human monkeypox in a man who returned to the United States from the United Kingdom and reported no sexual contact. He had vesicular and pustular skin lesions but no anogenital involvement.
Abraar Karan, Ashley R. Styczynski, ChunHong Huang, Malaya K. Sahoo, Krithika Srinivasan, Benjamin A. Pinsky, Jorge L. Salinas   +6 more
doaj   +1 more source

Detecting, Quantifying, and Isolating Monkeypox Virus in Suspected Cases, Spain

Emerging Infectious Diseases, 2023
When a monkeypox virus outbreak began in several parts of the world in May 2022, timely and accurate diagnosis became mandatory. In our laboratory, a real-time quantitative PCR was designed and evaluated in several patient samples and compared with ...
Marta E. Álvarez Argüelles, Zulema Pérez Martínez, Susana Rojo Alba, Jose María González Alba, Ana María Fernandez-Verdugo, Isabel Costales González, Garbriel Martín Rodríguez, Jose Antonio Boga Riveiro, Mario Margolles Martins, Santiago Melón García   +9 more
doaj   +1 more source