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An Update of Orthopoxvirus Molecular Evolution

Viruses, 2022
Although variola virus (VARV) has been eradicated through widespread vaccination, other orthopoxviruses pathogenic for humans circulate in nature. Recently, new orthopoxviruses, including some able to infect humans, have been found and their complete ...
Igor V Babkin
exaly   +3 more sources

Current Strategies for Selecting Recombinant Orthopoxvirus Proteins for Immunobiological and Diagnostic Applications [PDF]

Viruses
Orthopoxviruses are zoonotic DNA viruses of continuing public health importance, as highlighted by recent global mpox outbreaks. The high antigenic similarity among orthopoxviruses enables cross-reactive immune responses but complicates the development ...
Aigerim Zhakypbek, Lespek Kutumbetov, Gulnur Kuzembekova, Kamshat Shorayeva, Nurlan Kozhabergenov, Bekbolat Usserbayev, Gulnur Nakhanova, Kuanysh Jekebekov, Gaukhar Shynybekova, Akbope Abdykalyk, Aknur Ulankyzy, Temirlan Baiseit, Balzhan Myrzakhmetova, Olga Chervyakova, Kuandyk Zhugunissov   +14 more
doaj   +2 more sources

Zoonotic Orthopoxvirus Infection [PDF]

Case Reports in Dermatology
Introduction: Cowpox virus (CPXV) is a rare zoonotic orthopoxvirus infection, most commonly transmitted to humans via infected domestic cats.
Bernadett Kurz, Dennis Niebel, Susanne Bauer, Julian Kögel, Mark Berneburg, Sigrid Karrer   +5 more
doaj   +2 more sources

Targeting β2-Adrenergic Receptor Stability With Lycorine Reveals a Host-Directed Pathway for Antiviral Defense Against Poxviruses. [PDF]

Adv Sci (Weinh)
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Zhang X, Xu S, Zhang Z, Wan C, Wang X, Wang P, Yang H, Huang T, Yuan Y, Atique F, Yang R, He Y, Liu Z.   +12 more
europepmc   +2 more sources

Pox-AbDab: the orthopoxvirus antibody database [PDF]

Frontiers in Immunology
In August 2024, the World Health Organization declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in three years, emphasising the need for continued studies into its microbiology and potential ...
Henriette L. Capel, Eric Ji Da Wang, Benjamin H. Williams, Charlotte M. Deane, Matthew I. J. Raybould   +4 more
doaj   +2 more sources

A Global Health Alert on the Re-Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus. Mpox was first detected in the 1970s and mostly affects Central and West Africa.
Aqeel MB, Hanif A, Ahmad S, Shah FI, Javed B, Javed B, Iqbal S.   +6 more
europepmc   +2 more sources

Three neutralizing mAbs induced by MPXV A29L protein recognizing different epitopes act synergistically against orthopoxvirus

Emerging Microbes and Infections, 2023
The worldwide outbreak of the monkeypox virus (MPXV) has become a “Public Health Emergency of International Concern” (PHEIC). Severe monkeypox virus infection can be fatal, however, effective therapeutic methods are yet to be developed.
Jiayin Chen, Yuhao Lin
exaly   +3 more sources

Identification of Repurposed Drugs Against Monkeypox Virus Through Comprehensive Virtual Screening. [PDF]

Biotechnol J
Graphical Abstract and Lay Summary By combining interspecies protein analysis with advanced virtual screening, this study identifies potent repurposed drug candidates—including vindesine and LY2090314—targeting mpox DNA topoisomerase and polymerase. This workflow provides a rapid, practical framework for antiviral discovery against emerging infectious ...
Yu T, Jang WD, Lee SY.
europepmc   +2 more sources

Durability of the Humoral Response to MPXV Infection. [PDF]

J Int AIDS Soc
ABSTRACT Introduction Mpox virus (MPXV) re‐emerged in endemic countries in recent decades, resulting in large outbreaks in central and western Africa and a worldwide epidemic of clade IIb MPXV starting in 2022. Mpox cases in vaccinated persons, and a few documented reinfections, have raised questions about the durability of MPXV humoral immunity ...
Palmore TN.
europepmc   +2 more sources

Orthopoxvirus Seroprevalence and Infection Susceptibility in France, Bolivia, Laos, and Mali

Emerging Infectious Diseases, 2022
To determine a demographic overview of orthopoxvirus seroprevalence, we tested blood samples collected during 2003–2019 from France (n = 4,876), Bolivia (n = 601), Laos (n = 657), and Mali (n = 255) for neutralizing antibodies against vaccinia virus. In
Léa Luciani, Nathanaël Lapidus, Abdennour Amroun, Alessandra Falchi, Chanthala Souksakhone, Mayfong Mayxay, Audrey Dubot-Pérès, Paola Mariela Saba Villarroel, Issa Diarra, Ousmane Koita, Pierre Gallian, Xavier de Lamballerie   +11 more
doaj   +1 more source