Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
Apparition de lésions proches de la variole bovine chez des bovins en Israël
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1996 Les auteurs décrivent deux formes cliniques différentes de variole bovine apparues sporadiquement dans un troupeau laitier et dans un troupeau à viande.
I. Yeruham +3 more
doaj +1 more source
Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan. [PDF]
, 2011 Plague, which is most often caused by the bite of Yersinia pestis-infected fleas, is a rapidly progressing, serious disease that can be fatal without prompt antibiotic treatment.
Ayazi, E +13 more
core +1 more source
Diagnosis of Imported Monkeypox, Israel, 2018
Emerging Infectious Diseases, 2019 We report a case of monkeypox in a man who returned from Nigeria to Israel in 2018. Virus was detected in pustule swabs by transmission electron microscopy and PCR and confirmed by immunofluorescence assay, tissue culture, and ELISA.
Noam Erez +16 more
doaj +1 more source
Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]
, 2013 Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M +4 more
core +1 more source
Monkeypox: Current trends and therapeutic challenges
Annals of Medical Science and Research, 2022 Monkeypox is a viral zoonotic disease that mostly affects tropical rainforest regions of Central and West Africa, with infrequent exportations to other parts of the world.
Pritama Paul +4 more
doaj +1 more source
ENDEMIC ORTHOPOXVIRUS CIRCULATING IN PROCYONIDS IN MEXICO [PDF]
Journal of Wildlife Diseases, 2016 Limited serosurveillance studies suggested that orthopoxviruses (OPXV) are widespread in the US (e.g., Raccoonpox virus, Skunkpox virus, Volepox virus) and Brazil (Vaccinia virus); however, their animal reservoir(s) remain unconfirmed. Mexican mammal diversity includes several species related to those in which evidence for OPXV infections has been ...
Nadia F, Gallardo-Romero +13 more
openaire +2 more sources
Viral genomic features predictorthopoxvirusreservoir hosts
Communications Biology, 2023 AbstractOrthopoxviruses (OPVs), including the causative agents of smallpox and mpox have led to devastating outbreaks in human populations worldwide. However, the discontinuation of smallpox vaccination, which also provides cross-protection against related OPVs, has diminished global immunity to OPVs more broadly.
Katie K. Tseng +6 more
openaire +4 more sources
Development of ST-246® for Treatment of Poxvirus Infections
Viruses, 2010 ST-246 (Tecovirimat) is a small synthetic antiviral compound being developed to treat pathogenic orthopoxvirus infections of humans. The compound was discovered as part of a high throughput screen designed to identify inhibitors of vaccinia virus-induced
Dennis E. Hruby +3 more
doaj +1 more source
Rapid and high-throughput pan-Orthopoxvirus detection and identification using PCR and mass spectrometry. [PDF]
PLoS ONE, 2009 The genus Orthopoxvirus contains several species of related viruses, including the causative agent of smallpox (Variola virus). In addition to smallpox, several other members of the genus are capable of causing human infection, including monkeypox ...
Mark W Eshoo +16 more
doaj +1 more source