Results 21 to 30 of about 9,580 (245)

Orthopoxvirus Infections: Epidemiology, Clinical Picture, and Diagnostics (Scientific Review)

open access: yesПроблемы особо опасных инфекций, 2013
Lack of immunity among the population against pathogenic orthopoxviruses and an increased number of these infections human cases testify to the need of development of the rapid high-sensitive methods for species-specific orthopoxvirus diagnostics.
E. V. Gavrilova   +2 more
doaj   +3 more sources

Rapid and high-throughput pan-Orthopoxvirus detection and identification using PCR and mass spectrometry. [PDF]

open access: yesPLoS ONE, 2009
The genus Orthopoxvirus contains several species of related viruses, including the causative agent of smallpox (Variola virus). In addition to smallpox, several other members of the genus are capable of causing human infection, including monkeypox ...
Mark W Eshoo   +16 more
doaj   +2 more sources

An Increasing Danger of Zoonotic Orthopoxvirus Infections

open access: yesPLoS Pathogens, 2013
On May 8, 1980, the World Health Assembly at its 33(rd) session solemnly declared that the world and all its peoples had won freedom from smallpox and recommended ceasing the vaccination of the population against smallpox. Currently, a larger part of the world population has no immunity not only against smallpox but also against other zoonotic ...
Shchelkunov Sergei N.   +1 more
openaire   +5 more sources

A Global Health Alert on the Re-Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review. [PDF]

open access: yesHealth Sci Rep
ABSTRACT Background and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus. Mpox was first detected in the 1970s and mostly affects Central and West Africa.
Aqeel MB   +6 more
europepmc   +2 more sources

Human Monkeypox without Viral Prodrome or Sexual Exposure, California, USA, 2022

open access: yesEmerging Infectious Diseases, 2022
We report human monkeypox in a man who returned to the United States from the United Kingdom and reported no sexual contact. He had vesicular and pustular skin lesions but no anogenital involvement.
Abraar Karan   +6 more
doaj   +1 more source

Detecting, Quantifying, and Isolating Monkeypox Virus in Suspected Cases, Spain

open access: yesEmerging Infectious Diseases, 2023
When a monkeypox virus outbreak began in several parts of the world in May 2022, timely and accurate diagnosis became mandatory. In our laboratory, a real-time quantitative PCR was designed and evaluated in several patient samples and compared with ...
Marta E. Álvarez Argüelles   +9 more
doaj   +1 more source

Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines

open access: yesmBio, 2023
Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then.
Aline R. V. Souza   +4 more
doaj   +1 more source

Mpox multi-antigen mRNA vaccine candidates by a simplified manufacturing strategy afford efficient protection against lethal orthopoxvirus challenge

open access: yesEmerging Microbes and Infections, 2023
Current unprecedented mpox outbreaks in non-endemic regions represent a global public health concern. Although two live-attenuated vaccinia virus (VACV)-based vaccines have been urgently approved for people at high risk for mpox, a safer and more ...
Jiawei Zeng   +11 more
semanticscholar   +1 more source

Orthopoxvirus Zoonoses—Do We Still Remember and Are Ready to Fight?

open access: yesPathogens, 2023
The eradication of smallpox was an enormous achievement due to the global vaccination program launched by World Health Organization. The cessation of the vaccination program led to steadily declining herd immunity against smallpox, causing a health ...
M. Gieryńska   +7 more
semanticscholar   +1 more source

Ancient Gene Capture and Recent Gene Loss Shape the Evolution of Orthopoxvirus-Host Interaction Genes

open access: yesmBio, 2021
Orthopoxviruses (ORPV) include smallpox (variola) virus, one of the most devastating human pathogens, and vaccinia virus, comprising the vaccine used for smallpox eradication.
T. Senkevich   +4 more
semanticscholar   +1 more source

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