Results 41 to 50 of about 9,580 (245)

Validation and implementation of an orthopoxvirus qualitative real-time PCR for the diagnosis of monkeypox in the clinical laboratory

Journal of Clinical Virology, 2022
Background The globally concerning outbreak of monkeypox virus (MPXV) in non-endemic countries in 2022 warranted an increased capacity of diagnostic clinical testing.
Katharine Uhteg, H. Mostafa
semanticscholar   +1 more source

Development of monoclonal antibody-based antigens detection assays for orthopoxvirus and monkeypox virus

Journal of Infection, 2022
a CRISPR-Cas12a-based detection assay for monkeypox virus (MPXV) 1 . Nucleic acid the methods The diagnosis monkeypox MPXV Rapid detection are in detection of potentially they can provide in a cost-effective As a we monoclonal antibody-based antigens ...
Mengjun Li, Yuelin Wang, Chaohui Li, Rui Xu, Jiayin Chen, Junfang Zhang, Minghui Yang, Yushan Jiang, Yuqing Li, Zhujun Zeng, Zhiguang Wu, Wei Zhao, Bo Wu, Chenguang Shen   +13 more
semanticscholar   +1 more source

Trends of Pathogenicity and Potential Risk Evaluation of Central African Mpox Variant to Cause Global Public Health Emergency: A Cross-Sectional Analysis. [PDF]

Health Sci Rep
ABSTRACT Background With the re‐emergence of monkeypox (Mpox), it is vital for communities to assess and effectively respond to emerging outbreaks. This paper aims to review the potential of clade I Mpox to result in a widespread outbreak by assessing genetically enhanced virulence, transmission, and clinical manifestations.
Rahman MA, Kozlowich C, Katulka N, Thomas MR, Shanjana Y, Islam MR.   +5 more
europepmc   +2 more sources

Imported Monkeypox, Singapore

Emerging Infectious Diseases, 2020
In May 2019, we investigated monkeypox in a traveler from Nigeria to Singapore. The public health response included rapid identification of contacts, use of quarantine, and postexposure smallpox vaccination. No secondary cases were identified.
Sarah Ee Fang Yong, Oon Tek Ng, Zheng Jie Marc Ho, Tze Minn Mak, Kalisvar Marimuthu, Shawn Vasoo, Tsin Wen Yeo, Yi Kai Ng, Lin Cui, Zannatul Ferdous, Po Ying Chia, Bryan Jun Wei Aw, Charmaine Malenab Manauis, Constance Khia Ki Low, Guanhao Chan, Xinyi Peh, Poh Lian Lim, Li Ping Angela Chow, Monica Chan, Vernon Jian Ming Lee, Raymond Tzer Pin Lin, Mok Kwee Derrick Heng, Yee Sin Leo   +22 more
doaj   +1 more source

ENDEMIC ORTHOPOXVIRUS CIRCULATING IN PROCYONIDS IN MEXICO [PDF]

Journal of Wildlife Diseases, 2016
Limited serosurveillance studies suggested that orthopoxviruses (OPXV) are widespread in the US (e.g., Raccoonpox virus, Skunkpox virus, Volepox virus) and Brazil (Vaccinia virus); however, their animal reservoir(s) remain unconfirmed. Mexican mammal diversity includes several species related to those in which evidence for OPXV infections has been ...
Nadia F, Gallardo-Romero, Nidia, Aréchiga-Ceballos, Ginny L, Emerson, Flor O, Martínez-Martínez, Jeffrey B, Doty, Yoshinori J, Nakazawa, Emilio, Rendón-Franco, Claudia I, Muñoz-García, Claudia, Villanueva-García, Citlali, Ramírez-Cid, Lilia M, Gama-Campillo, Fernando, Gual-Sill, Álvaro, Aguilar-Setién, Darin S, Carroll   +13 more
openaire   +2 more sources

Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps?

Viruses, 2017
Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo.
Malachy I. Okeke, Arinze S. Okoli, Diana Diaz, Collins Offor, Taiwo G. Oludotun, Morten Tryland, Thomas Bøhn, Ugo Moens   +7 more
doaj   +1 more source

Prevalence of Undiagnosed Monkeypox Virus Infections during Global Mpox Outbreak, United States, June–September 2022

Emerging Infectious Diseases, 2023
Since May 2022, mpox has been identified in 108 countries without endemic disease; most cases have been in gay, bisexual, or other men who have sex with men.
Faisal S. Minhaj, Vijay Singh, Stephanie E. Cohen, Michael Townsend, Hyman Scott, John Szumowski, C. Bradley Hare, Pallavi Upadhyay, Jairus Reddy, Barbara Alexander, Nicolle Baird, Terese Navarra, Lalita Priyamvada, Nhien Wynn, William C. Carson, Solomon Odafe, Sarah Anne J. Guagliardo, Emily Sims, Agam K. Rao, Panayampalli S. Satheshkumar, Paul J. Weidle, Christina L. Hutson   +21 more
doaj   +1 more source

Genomic Sequencing and Analysis of a Novel Human Cowpox Virus With Mosaic Sequences From North America and Old World Orthopoxvirus

Frontiers in Microbiology, 2022
Orthopoxviruses (OPXVs) not only infect their natural hosts, but some OPXVs can also cause disease in humans. Previously, we partially characterized an OPXV isolated from an 18-year-old male living in Northern Norway.
Diana Diaz-Cánova, U. Moens, A. Brinkmann, A. Nitsche, M. I. Okeke   +4 more
semanticscholar   +1 more source

An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications

Expert Review of Anti-Infective Therapy, 2020
Introduction Tecovirimat (TPOXX®; ST-246) was approved for the treatment of symptomatic smallpox by the USFDA in July of 2018 and has been stockpiled by the US government for use in a smallpox outbreak.
Andrew T. Russo, D. Grosenbach, J. Chinsangaram, Kady M. Honeychurch, Paul G Long, Candace E Lovejoy, B. Maiti, I. Meara, D. Hruby   +8 more
semanticscholar   +1 more source

A Nucleic Acid-Based Orthopoxvirus Vaccine Targeting the Vaccinia Virus L1, A27, B5, and A33 Proteins Protects Rabbits against Lethal Rabbitpox Virus Aerosol Challenge

Journal of Virology, 2021
The eradication of smallpox and subsequent cessation of vaccination have left a majority of the population susceptible to variola virus or other emerging poxviruses. This is exemplified by human monkeypox, as evidenced by the increase in reported endemic
E. Mucker, J. W. Golden, Christopher D. Hammerbeck, Jennifer M Kishimori, M. Royals, Mathew D Joselyn, J. Ballantyne, Aysegul Nalca, J. Hooper   +8 more
semanticscholar   +1 more source