Results 1 to 10 of about 16,696 (211)

Poxvirus Recombination

Pathogens, 2022
Genetic recombination is used as a tool for modifying the composition of poxvirus genomes in both discovery and applied research. This review documents the history behind the development of these tools as well as what has been learned about the processes

exaly   +6 more sources

Targeting β2-Adrenergic Receptor Stability With Lycorine Reveals a Host-Directed Pathway for Antiviral Defense Against Poxviruses. [PDF]

Adv Sci (Weinh)
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Zhang X, Xu S, Zhang Z, Wan C, Wang X, Wang P, Yang H, Huang T, Yuan Y, Atique F, Yang R, He Y, Liu Z.   +12 more
europepmc   +2 more sources

Fish Poxviruses on the Rise: Prospects for Aquatic Health. [PDF]

J Fish Dis
ABSTRACT Fish poxviruses are increasingly recognised as emerging pathogens of fish and should be considered in cases of unexplained gill or skin pathology. Carp edema virus (CEV), the causative agent of koi sleepy disease in common carp and koi (Cyprinus carpio), represents the first known example.
Adamek M, Matras M, Ojelade OC, Sano M, Gjessing MC, Korytar T, Falco A, Rakus K, Jung-Schroers V, Doszpoly A.   +9 more
europepmc   +2 more sources

Evaluation of a portable multiplex real-time pcr assay for the detection of monkeypox virus and non-variola orthopoxviruses [PDF]

Virology Journal
Monkeypox (mpox) is the most significant orthopoxvirus (OPXV) infection in humans since smallpox eradication. The World Health Organization (WHO) has twice declared public health emergency of international concern due to the expansive spread of clade I ...
Shanshan Li, Nabojeet Das, Natalie Miller, Ariel Caudle, Kimberly Wilkins, Theodora Khan, Stefan Pfotenhauer, Amy Saunders, Christina L. Hutson, Kodumudi S. Venkateswaran, William M. Nelson, Neeraja Venkateswaran, Panayampalli S. Satheshkumar, Michael B. Townsend   +13 more
doaj   +2 more sources

Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model

mSphere, 2021
Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic.
Christina L. Hutson, Ashley V. Kondas, Mathew R. Mauldin, Jeffrey B. Doty, Irma M. Grossi, Clint N. Morgan, Sharon Dietz Ostergaard, Christine M. Hughes, Yoshinori Nakazawa, Chantal Kling, Brock E. Martin, James A. Ellison, Darin D. Carroll, Nadia F. Gallardo-Romero, Victoria A. Olson   +14 more
doaj   +1 more source

Rabies experts on demand: A cross‐sectional study describing the use of a rabies telehealth service

Public Health Challenges, 2023
Background Rabies expert on demand (REOD) telehealth service is provided by the U.S. Centers for Disease Control and Prevention (CDC) to assist public health practitioners, health providers, and the public to interpret national and international rabies ...
Sarah E. Baker, Yasmeen B. Ross, James A. Ellison, Benjamin P. Monroe, Lillian A. Orciari, Brett W. Petersen, Agam K. Rao, Ryan M. Wallace   +7 more
doaj   +1 more source

Revealing the complexity of vampire bat rabies “spillover transmission”

Infectious Diseases of Poverty, 2023
Background The term virus ‘spillover’ embodies a highly complex phenomenon and is often used to refer to viral transmission from a primary reservoir host to a new, naïve yet susceptible and permissive host species.
Luis E. Escobar, Andres Velasco-Villa, Panayampalli S. Satheshkumar, Yoshinori Nakazawa, Paige Van de Vuurst   +4 more
doaj   +1 more source

Analysis of available animal testing data to propose peer-derived quantitative thresholds for determining adequate surveillance capacity for rabies

Scientific Reports, 2023
Historical targets for country-level animal rabies testing volumes were abandoned due to ethical and welfare concerns, and interpretation challenges of testing healthy animals.
Faisal S. Minhaj, Sarah C. Bonaparte, Cassandra Boutelle, Ryan M. Wallace   +3 more
doaj   +1 more source

A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Scientific Reports, 2022
Human rabies remains a globally significant public health problem. Replacement of polyclonal anti-rabies immunoglobulin (RIG), a passive component of rabies post-exposure prophylaxis (PEP), with a monoclonal antibody (MAb), would eliminate the cost and ...
Monir Ejemel, Todd G. Smith, Lauren Greenberg, William C. Carson, David Lowe, Yong Yang, Felix R. Jackson, Clint N. Morgan, Brock E. Martin, Chantal Kling, Christina L. Hutson, Nadia Gallardo-Romero, James A. Ellison, Susan Moore, Adam Buzby, John Sullivan-Bolyai, Mark Klempner, Yang Wang   +17 more
doaj   +1 more source

Identification of Novel Cetacean Poxviruses in Cetaceans Stranded in South West England. [PDF]

PLoS ONE, 2015
Poxvirus infections in marine mammals have been mainly reported through their clinical lesions and electron microscopy (EM). Poxvirus particles in association with such lesions have been demonstrated by EM and were previously classified as two new ...
James Barnett, Akbar Dastjerdi, Nick Davison, Rob Deaville, David Everest, Julie Peake, Christopher Finnegan, Paul Jepson, Falko Steinbach   +8 more
doaj   +1 more source