Results 1 to 10 of about 20,635 (251)
Pathogens, 2022 Genetic recombination is used as a tool for modifying the composition of poxvirus genomes in both discovery and applied research. This review documents the history behind the development of these tools as well as what has been learned about the processes
David Hugh Evans
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DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
Frontiers in Immunology, 2020 As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response.
Leiliang Zhang
exaly +4 more sources
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses
Nature Communications, 2023 Poxviruses are unusual DNA viruses that replicate in the cytoplasm. To do so, they encode approximately 100 immunomodulatory proteins that counteract cytosolic nucleic acid sensors such as cGAMP synthase (cGAS) along with several other antiviral response
Nathan Meade +6 more
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Molecular Mechanisms of Poxvirus Evolution [PDF]
mBio, 2022 Poxviruses are often thought to evolve relatively slowly because they are double-stranded DNA pathogens with proofreading polymerases. However, poxviruses have highly adaptable genomes and can undergo relatively rapid genotypic and phenotypic change, as ...
Greg Brennan +8 more
semanticscholar +7 more sources
Vaccines, 2022 Smallpox, an epidemic disease caused by Orthopoxvirus variola, was eradicated worldwide through immunization. The immunization against smallpox was discontinued in 1980.
Xiuling Gu +7 more
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Genomic Analysis of Novel Poxvirus Brazilian Porcupinepox Virus, Brazil, 2019
Emerging Infectious Diseases, 2021 We obtained the complete sequence of a novel poxvirus, tentatively named Brazilian porcupinepox virus, from a wild porcupine (Coendou prehensilis) in Brazil that had skin and internal lesions characteristic of poxvirus infection.
Aline S. Hora +7 more
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The Genome of Yoka Poxvirus [PDF]
Journal of Virology, 2011 Yoka poxvirus was isolated almost four decades ago from a mosquito pool in the Central African Republic. Its classification as a poxvirus is based solely upon the morphology of virions visualized by electron microscopy. Here we describe sequencing of the
Guoyan Zhao +7 more
core +3 more sources
Detection of Novel Poxvirus from Gray Seal (Halichoerus grypus), Germany
Emerging Infectious Diseases, 2023 We detected a novel poxvirus from a gray seal (Halichoerus grypus) from the North Sea, Germany. The juvenile animal showed pox-like lesions and deteriorating overall health condition and was finally euthanized. Histology, electron microscopy, sequencing,
Florian Pfaff +8 more
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Viruses, 2021 Emerging viral disease is a significant concern, with potential consequences for human, animal and environmental health. Over the past several decades, multiple novel viruses have been found in wildlife species, including reptiles, and often pose a major
Subir Sarker +3 more
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Poxvirus under the eyes of electron microscope
Applied Microscopy, 2022 Zoonotic poxvirus infections pose significant threat to human health as we have witnessed recent spread of monkeypox. Therefore, insights into molecular mechanism behind poxvirus replication cycle are needed for the development of efficient antiviral ...
Jaekyung Hyun
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