Results 21 to 30 of about 24,392 (225)

Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]

, 2013
Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M, Liu, Jia, McFadden, Grant, Rahman, Masmudur M, Rothenburg, Stefan   +4 more
core   +1 more source

Inactivated Rabies Virus-Vectored Immunocontraceptive Vaccine in a Thermo-Responsive Hydrogel Induces High and Persistent Antibodies against Rabies, but Insufficient Antibodies against Gonadotropin-Releasing Hormone for Contraception

Vaccines, 2019
Rabies is preventable through vaccination, but the need to mount annual canine vaccination campaigns presents major challenges in rabies control and prevention.
Xianfu Wu, Yong Yang, Chantal Kling, Laurie Seigler, Nadia F. Gallardo-Romero, Brock E. Martin, Todd G. Smith, Victoria A. Olson   +7 more
doaj   +1 more source

IMVAMUNE^® and ACAM2000^® Provide Different Protection against Disease When Administered Postexposure in an Intranasal Monkeypox Challenge Prairie Dog Model

Vaccines, 2020
The protection provided by smallpox vaccines when used after exposure to Orthopoxviruses is poorly understood. Postexposu re administration of 1st generation smallpox vaccines was effective during eradication.
M. Shannon Keckler, Johanna S Salzer, Nishi Patel, Michael B Townsend, Yoshinori J Nakazawa, Jeffrey B Doty, Nadia F Gallardo-Romero, Panayampalli S Satheshkumar, Darin S Carroll, Kevin L Karem, Inger K Damon   +10 more
doaj   +1 more source

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

Population, sexual and reproductive health, rights and sustainable development: forging a common agenda. [PDF]

, 2010
This article suggests that sexual and reproductive health and rights activists seeking to influence the post-2015 international development paradigm must work with sustainable development advocates concerned with a range of issues, including climate ...
Campbell, D. M., Carter, P. E., Collins-Emerson, J. M., French, N. P., Hathaway, S., Marshall, J., Midwinter, A. C., Mullner, P., Pirie, R., Shadbolt, T., Spencer, Simon E. F., Wilson, D. J.   +11 more
core   +1 more source

Emergence of a Novel Pathogenic Poxvirus Infection in the Endangered Green Sea Turtle (Chelonia mydas) Highlights a Key Threatening Process

Viruses, 2021
Emerging viral disease is a significant concern, with potential consequences for human, animal and environmental health. Over the past several decades, multiple novel viruses have been found in wildlife species, including reptiles, and often pose a major
Subir Sarker, Christabel Hannon, Ajani Athukorala, Helle Bielefeldt-Ohmann   +3 more
doaj   +1 more source

Diminished Intracellular Invariant Chain Expression Following Vaccinia Virus Infection [PDF]

, 2009
Vaccinia virus (VV) has been used as a vaccine to eradicate smallpox and as a vaccine for HIV and tumors. However, the immunoevasive properties of VV, have raised safety concerns.
Blum, Janice S., Wang, Nan, Weber, Ekkehard   +2 more
core   +1 more source

A Phylogeographic Investigation of African Monkeypox

Viruses, 2015
Monkeypox is a zoonotic disease caused by a virus member of the genus Orthopoxvirus and is endemic to Central and Western African countries. Previous work has identified two geographically disjuct clades of monkeypox virus based on the analysis of a few ...
Yoshinori Nakazawa, Matthew R. Mauldin, Ginny L. Emerson, Mary G. Reynolds, R. Ryan Lash, Jinxin Gao, Hui Zhao, Yu Li, Jean-Jacques Muyembe, Placide Mbala Kingebeni, Okito Wemakoy, Jean Malekani, Kevin L. Karem, Inger K. Damon, Darin S. Carroll   +14 more
doaj   +1 more source

Squirrelpox virus: assessing prevalence, transmission and environmental degradation [PDF]

, 2014
Red squirrels (Sciurus vulgaris) declined in Great Britain and Ireland during the last century, due to habitat loss and the introduction of grey squirrels (Sciurus carolinensis), which competitively exclude the red squirrel and act as a reservoir for ...
AC Scott, AD Middleton, AR Bharti, AW Sainsbury, AW Sainsbury, B Carroll, Christopher James Johnson, CJ McInnes, CJ McInnes, CM Bruemmer, Colin McInnes, CW Livingston, D Sweet, David Everest, David G. Tosh, DJ Everest, DJ Everest, DM Tompkins, ER Kallio, J Gurnell, Jaimie T. A. Dick, JP Duff, JP LaRose, JW Atkin, LA Wauters, Lisa M. Collins, Mike Scantlebury, Neil D. Warnock, Neil Reid, Nikki Marks, SP Rushton, VR Simpson, W. Ian Montgomery   +32 more
core   +2 more sources

Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research

Viruses, 2017
Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource ...
Mary G. Reynolds, Andrea M. McCollum, Beatrice Nguete, Robert Shongo Lushima, Brett W. Petersen   +4 more
doaj   +1 more source