Results 21 to 30 of about 16,696 (211)

Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus

Drug Design, Development and Therapy, 2018
Euna Cho,1,2,* Eun Jin Ryu,2,3,* Fen Jiang,2,4 Ung Bae Jeon,3 Mong Cho,1,2 Cy Hyun Kim,1 Miyoung Kim,1 Nam Deuk Kim,5 Tae-Ho Hwang1,2 1Department of Pharmacology and Medical Research Center (MRC), Pusan National University School of Medicine, Yangsan ...
Cho E, Ryu EJ, Jiang F, Jeon UB, Cho M, Kim CH, Kim M, Kim ND, Hwang TH   +8 more
doaj   +1 more source

Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins

Frontiers in Immunology, 2021
Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins.
Haoran Cui, Haoran Cui, Haoran Cui, Yaxian Zhang, Yaxian Zhang, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +7 more
doaj   +1 more source

From actually toxic to highly specific – novel drugs against poxviruses [PDF]

, 2007
The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral
Schnierle Barbara, Sliva Katja, Sliva, Katja, Schnierle, Barbara   +3 more
core   +1 more source

Poxvirus pathogenesis

Microbiological Reviews, 1991
Poxviruses are a highly successful family of pathogens, with variola virus, the causative agent of smallpox, being the most notable member. Poxviruses are unique among animal viruses in several respects. First, owing to the cytoplasmic site of virus replication, the virus encodes many enzymes required either for macromolecular precursor pool regulation
R M, Buller, G J, Palumbo
openaire   +2 more sources

Israeli Rousettus aegyptiacus Pox Virus (IsrRAPXV) Infection in Juvenile Egyptian Fruit Bat (Rousettus aegyptiacus): Clinical Findings and Molecular Detection

Viruses, 2021
During 2019, five carcasses of juvenile Egyptian fruit bats (Rousettus aegyptiacus) were submitted to the Kimron Veterinary Institute. These bats exhibited typical poxvirus like lesion plaques of different sizes on the skin, abdomen and the ventral side ...
Dan David, Irit Davidson, Sharon Karniely, Nir Edery, Ariela Rosenzweig, Asaf Sol   +5 more
doaj   +1 more source

DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection

Frontiers in Immunology, 2020
As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response.
Yue Lu, Yue Lu, Yue Lu, Yue Lu, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +8 more
doaj   +1 more source

Inactivated Rabies Virus-Vectored Immunocontraceptive Vaccine in a Thermo-Responsive Hydrogel Induces High and Persistent Antibodies against Rabies, but Insufficient Antibodies against Gonadotropin-Releasing Hormone for Contraception

Vaccines, 2019
Rabies is preventable through vaccination, but the need to mount annual canine vaccination campaigns presents major challenges in rabies control and prevention.
Xianfu Wu, Yong Yang, Chantal Kling, Laurie Seigler, Nadia F. Gallardo-Romero, Brock E. Martin, Todd G. Smith, Victoria A. Olson   +7 more
doaj   +1 more source

IMVAMUNE^® and ACAM2000^® Provide Different Protection against Disease When Administered Postexposure in an Intranasal Monkeypox Challenge Prairie Dog Model

Vaccines, 2020
The protection provided by smallpox vaccines when used after exposure to Orthopoxviruses is poorly understood. Postexposu re administration of 1st generation smallpox vaccines was effective during eradication.
M. Shannon Keckler, Johanna S Salzer, Nishi Patel, Michael B Townsend, Yoshinori J Nakazawa, Jeffrey B Doty, Nadia F Gallardo-Romero, Panayampalli S Satheshkumar, Darin S Carroll, Kevin L Karem, Inger K Damon   +10 more
doaj   +1 more source

MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection [PDF]

, 2010
Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Camus-Bouclainville, Christelle, Camus-Bouclainville Christelle, Jacqueline Gelfi, Sophie Blanié, Bertagnoli Stéphane, Blanié, Sophie, Gelfi, Jacqueline, Blanié Sophie, Christelle Camus-Bouclainville, Stéphane Bertagnoli, Bertagnoli, Stéphane, Gelfi Jacqueline   +11 more
core   +1 more source

T helper 1 effector memory CD4+ T cells protect the skin from poxvirus infection

Cell Reports, 2023
Summary: Poxvirus infections of the skin are a recent emerging public health concern, yet the mechanisms that mediate protective immunity against these viral infections remain largely unknown.
Jake C. Harbour, Mahmoud Abdelbary, John B. Schell, Samantha P. Fancher, Jack J. McLean, Taylen J. Nappi, Susan Liu, Timothy J. Nice, Zheng Xia, Klaus Früh, Jeffrey C. Nolz   +10 more
doaj   +1 more source