Results 21 to 30 of about 20,635 (251)

Novel Poxvirus in Big Brown Bats, Northwestern United States

Emerging Infectious Diseases, 2013
A wildlife hospital and rehabilitation center in northwestern United States received several big brown bats with necrosuppurative osteomyelitis in multiple joints. Wing and joint tissues were positive by PCR for poxvirus. Thin-section electron microscopy
Ginny L. Emerson, Robert Nordhausen, Michael M. Garner, John R. Huckabee, Steven Johnson, Ron D. Wohrle, Whitni B. Davidson, Kimberly Wilkins, Yu Li, Jeffrey B. Doty, Nadia F. Gallardo-Romero, Maureen G. Metcalfe, Kevin L. Karem, Inger K. Damon, Darin S. Carroll   +14 more
doaj   +2 more sources

Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model

mSphere, 2021
Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic.
Christina L. Hutson, Ashley V. Kondas, Mathew R. Mauldin, Jeffrey B. Doty, Irma M. Grossi, Clint N. Morgan, Sharon Dietz Ostergaard, Christine M. Hughes, Yoshinori Nakazawa, Chantal Kling, Brock E. Martin, James A. Ellison, Darin D. Carroll, Nadia F. Gallardo-Romero, Victoria A. Olson   +14 more
doaj   +1 more source

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

Frontiers in Immunology, 2023
Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies. In addition to their oncolytic capacity and immunogenic influence, they can be readily engineered to express multiple large transgenes.
J. Whelan, R. Singaravelu, Fuan Wang, A. Pelin, Levi A. Tamming, G. Pugliese, N. Martin, Mathieu J. F. Crupi, Julia Petryk, Bradley Austin, Xiao-peng He, R. Marius, Jessie Duong, Carter Jones, E. E. Fekete, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Mike Huh, Matt Y. Tang, Zaid Taha, Elena Scut, J. Diallo, T. Azad, B. Lichty, C. Ilkow, J. Bell   +26 more
semanticscholar   +1 more source

Therapeutic strategies for human poxvirus infections: Monkeypox (mpox), smallpox, molluscipox, and orf

Travel Medicine and Infectious Disease, 2022
Therapeutic and vaccine development for human poxvirus infections (e.g., monkeypox (mpox) virus, variola virus, molluscum contagiosum virus, orf virus) has been largely deserted, especially after the eradication of smallpox by 1980.
E. De Clercq, Yike Jiang, Guangdi Li
semanticscholar   +1 more source

Rabies experts on demand: A cross‐sectional study describing the use of a rabies telehealth service

Public Health Challenges, 2023
Background Rabies expert on demand (REOD) telehealth service is provided by the U.S. Centers for Disease Control and Prevention (CDC) to assist public health practitioners, health providers, and the public to interpret national and international rabies ...
Sarah E. Baker, Yasmeen B. Ross, James A. Ellison, Benjamin P. Monroe, Lillian A. Orciari, Brett W. Petersen, Agam K. Rao, Ryan M. Wallace   +7 more
doaj   +1 more source

Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus

Drug Design, Development and Therapy, 2018
Euna Cho,1,2,* Eun Jin Ryu,2,3,* Fen Jiang,2,4 Ung Bae Jeon,3 Mong Cho,1,2 Cy Hyun Kim,1 Miyoung Kim,1 Nam Deuk Kim,5 Tae-Ho Hwang1,2 1Department of Pharmacology and Medical Research Center (MRC), Pusan National University School of Medicine, Yangsan ...
Cho E, Ryu EJ, Jiang F, Jeon UB, Cho M, Kim CH, Kim M, Kim ND, Hwang TH   +8 more
doaj   +1 more source

Adamantane derivatives as potential inhibitors of p37 major envelope protein and poxvirus reproduction. Design, synthesis and antiviral activity

European journal of medicinal chemistry, 2021
Currently, smallpox, caused by the variola virus belonging to the poxvirus family, has been completely eradicated according to the WHO. However, other representatives of poxviruses, such as vaccinia virus, cowpox virus, ectromelia virus, monkeypox virus,
V. A. Shiryaev, M. Y. Skomorohov, M. Leonova, N. Bormotov, O. Serova, L. Shishkina, A. Agafonov, R. Maksyutov, Yurii Klimochkin   +8 more
semanticscholar   +1 more source

A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Scientific Reports, 2022
Human rabies remains a globally significant public health problem. Replacement of polyclonal anti-rabies immunoglobulin (RIG), a passive component of rabies post-exposure prophylaxis (PEP), with a monoclonal antibody (MAb), would eliminate the cost and ...
Monir Ejemel, Todd G. Smith, Lauren Greenberg, William C. Carson, David Lowe, Yong Yang, Felix R. Jackson, Clint N. Morgan, Brock E. Martin, Chantal Kling, Christina L. Hutson, Nadia Gallardo-Romero, James A. Ellison, Susan Moore, Adam Buzby, John Sullivan-Bolyai, Mark Klempner, Yang Wang   +17 more
doaj   +1 more source

Analysis of available animal testing data to propose peer-derived quantitative thresholds for determining adequate surveillance capacity for rabies

Scientific Reports, 2023
Historical targets for country-level animal rabies testing volumes were abandoned due to ethical and welfare concerns, and interpretation challenges of testing healthy animals.
Faisal S. Minhaj, Sarah C. Bonaparte, Cassandra Boutelle, Ryan M. Wallace   +3 more
doaj   +1 more source

Revealing the complexity of vampire bat rabies “spillover transmission”

Infectious Diseases of Poverty, 2023
Background The term virus ‘spillover’ embodies a highly complex phenomenon and is often used to refer to viral transmission from a primary reservoir host to a new, naïve yet susceptible and permissive host species.
Luis E. Escobar, Andres Velasco-Villa, Panayampalli S. Satheshkumar, Yoshinori Nakazawa, Paige Van de Vuurst   +4 more
doaj   +1 more source