Results 21 to 30 of about 16,870 (170)

From actually toxic to highly specific – novel drugs against poxviruses [PDF]

, 2007
The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral
Schnierle Barbara, Sliva Katja, Sliva, Katja, Schnierle, Barbara   +3 more
core   +1 more source

Israeli Rousettus aegyptiacus Pox Virus (IsrRAPXV) Infection in Juvenile Egyptian Fruit Bat (Rousettus aegyptiacus): Clinical Findings and Molecular Detection

Viruses, 2021
During 2019, five carcasses of juvenile Egyptian fruit bats (Rousettus aegyptiacus) were submitted to the Kimron Veterinary Institute. These bats exhibited typical poxvirus like lesion plaques of different sizes on the skin, abdomen and the ventral side ...
Dan David, Irit Davidson, Sharon Karniely, Nir Edery, Ariela Rosenzweig, Asaf Sol   +5 more
doaj   +1 more source

DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection

Frontiers in Immunology, 2020
As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response.
Yue Lu, Yue Lu, Yue Lu, Yue Lu, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +8 more
doaj   +1 more source

Inactivated Rabies Virus-Vectored Immunocontraceptive Vaccine in a Thermo-Responsive Hydrogel Induces High and Persistent Antibodies against Rabies, but Insufficient Antibodies against Gonadotropin-Releasing Hormone for Contraception

Vaccines, 2019
Rabies is preventable through vaccination, but the need to mount annual canine vaccination campaigns presents major challenges in rabies control and prevention.
Xianfu Wu, Yong Yang, Chantal Kling, Laurie Seigler, Nadia F. Gallardo-Romero, Brock E. Martin, Todd G. Smith, Victoria A. Olson   +7 more
doaj   +1 more source

IMVAMUNE^® and ACAM2000^® Provide Different Protection against Disease When Administered Postexposure in an Intranasal Monkeypox Challenge Prairie Dog Model

Vaccines, 2020
The protection provided by smallpox vaccines when used after exposure to Orthopoxviruses is poorly understood. Postexposu re administration of 1st generation smallpox vaccines was effective during eradication.
M. Shannon Keckler, Johanna S Salzer, Nishi Patel, Michael B Townsend, Yoshinori J Nakazawa, Jeffrey B Doty, Nadia F Gallardo-Romero, Panayampalli S Satheshkumar, Darin S Carroll, Kevin L Karem, Inger K Damon   +10 more
doaj   +1 more source

A Phylogeographic Investigation of African Monkeypox

Viruses, 2015
Monkeypox is a zoonotic disease caused by a virus member of the genus Orthopoxvirus and is endemic to Central and Western African countries. Previous work has identified two geographically disjuct clades of monkeypox virus based on the analysis of a few ...
Yoshinori Nakazawa, Matthew R. Mauldin, Ginny L. Emerson, Mary G. Reynolds, R. Ryan Lash, Jinxin Gao, Hui Zhao, Yu Li, Jean-Jacques Muyembe, Placide Mbala Kingebeni, Okito Wemakoy, Jean Malekani, Kevin L. Karem, Inger K. Damon, Darin S. Carroll   +14 more
doaj   +1 more source

Emergence of a Novel Pathogenic Poxvirus Infection in the Endangered Green Sea Turtle (Chelonia mydas) Highlights a Key Threatening Process

Viruses, 2021
Emerging viral disease is a significant concern, with potential consequences for human, animal and environmental health. Over the past several decades, multiple novel viruses have been found in wildlife species, including reptiles, and often pose a major
Subir Sarker, Christabel Hannon, Ajani Athukorala, Helle Bielefeldt-Ohmann   +3 more
doaj   +1 more source

Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research

Viruses, 2017
Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource ...
Mary G. Reynolds, Andrea M. McCollum, Beatrice Nguete, Robert Shongo Lushima, Brett W. Petersen   +4 more
doaj   +1 more source

Modeling enzootic raccoon rabies from land use patterns - Georgia (USA) 2006-2010 [v1; ref status: indexed, http://f1000r.es/2i3]

F1000Research, 2013
We analyzed how land-use patterns and changes in urbanization influence reported rabid raccoons in Georgia from 2006 - 2010.  Using Geographical Information Systems and rabies surveillance data, multivariate analysis was conducted on 15 land-use ...
John E. Duke, Jesse D. Blanton, Melissa Ivey, Charles Rupprecht   +3 more
doaj   +1 more source

Vaccinia virus replication is not affected by APOBEC3 family members [PDF]

, 2006
Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd, Kremer Melanie, Schnierle Barbara S, Yasemin Suezer, Suezer, Yasemin, Martinez-Fernandez Yolanda, Schnierle, Barbara, Münk Carsten, Sutter, Gerd, Yolanda Martinez-Fernandez, Melanie Kremer, Barbara S Schnierle, Münk, Carsten, Suezer Yasemin, Gerd Sutter, Martinez-Fernandez, Yolanda, Carsten Münk, Kremer, Melanie   +17 more
core   +1 more source