Results 41 to 50 of about 16,696 (211)
Proceedings of the National Academy of Sciences, 2007 Poxviruses are large enveloped viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. At least six virus-encoded proteins are required for synthesis and processing of the double-stranded DNA genome of vaccinia virus, the prototype member of the family. One of these proteins, D5, is an NTPase that contains an N-
Frank S, De Silva +4 more
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Laboratory Infection of Novel Akhmeta Virus in CAST/EiJ Mice
Viruses, 2020 Akhmeta virus is a zoonotic Orthopoxvirus first identified in 2013 in the country of Georgia. Subsequent ecological investigations in Georgia have found evidence that this virus is widespread in its geographic distribution within the country and in its ...
Clint N. Morgan +10 more
doaj +1 more source
The 5'-poly(A) leader of poxvirus mRNA confers a translational advantage that can be achieved in cells with impaired cap-dependent translation. [PDF]
PLoS Pathogens, 2017 The poly(A) leader at the 5'-untranslated region (5'-UTR) is an unusually striking feature of all poxvirus mRNAs transcribed after viral DNA replication (post-replicative mRNAs).
Pragyesh Dhungel +2 more
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Antiviral Ranpirnase TMR-001 Inhibits Rabies Virus Release and Cell-to-Cell Infection In Vitro
Viruses, 2020 Currently, no rabies virus-specific antiviral drugs are available. Ranpirnase has strong antitumor and antiviral properties associated with its ribonuclease activity.
Todd G. Smith +12 more
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PLoS Pathogens, 2022 The evolutionarily successful poxviruses possess effective and diverse strategies to circumvent or overcome host defense mechanisms. Poxviruses encode many immunoregulatory proteins to evade host immunity to establish a productive infection and have ...
Steven J Conrad +7 more
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Vaccines, 2020 Four decades after the eradication of smallpox, poxviruses continue to threaten the health of humans and other animals. Vaccinia virus (VACV) was used as the vaccine that successfully eradicated smallpox and is a prototypic member of the poxvirus family.
Chen Peng +7 more
doaj +1 more source
Journal of General Virology, 1980 The poxvirus Cotia was studied by electron microscopy and by serological and biochemical analyses. Thin-sectioned preparations of infected Vero cells indicated that Cotia virus morphogenesis was similar to other mammalian poxviruses; unique filamentous structures and inclusion matrices were apparent in the cytoplasm.
J J, Esposito +5 more
openaire +2 more sources
Poxvirus under the eyes of electron microscope
Applied Microscopy, 2022 Zoonotic poxvirus infections pose significant threat to human health as we have witnessed recent spread of monkeypox. Therefore, insights into molecular mechanism behind poxvirus replication cycle are needed for the development of efficient antiviral ...
Jaekyung Hyun
doaj +1 more source
Advanced Science, EarlyView.EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li +9 more
wiley +1 more source
Vaccination contre la souche influenza PR8 à l'aide d'un vaccin recombinant SG33-M2e [PDF]
, 2010 Cette étude présente un essai d’immunisation à l’aide d’un vaccin recombinant poxviral. Le processus de fabrication du vaccin est basé sur la fusion protéique entre l’antigène considéré et une protéine d’enveloppe du poxvirus.
Boyer, Guillaume
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