Results 41 to 50 of about 20,635 (251)

T helper 1 effector memory CD4+ T cells protect the skin from poxvirus infection

Cell Reports, 2023
Summary: Poxvirus infections of the skin are a recent emerging public health concern, yet the mechanisms that mediate protective immunity against these viral infections remain largely unknown.
Jake C. Harbour, Mahmoud Abdelbary, John B. Schell, Samantha P. Fancher, Jack J. McLean, Taylen J. Nappi, Susan Liu, Timothy J. Nice, Zheng Xia, Klaus Früh, Jeffrey C. Nolz   +10 more
doaj   +1 more source

MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection [PDF]

, 2010
Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Camus-Bouclainville, Christelle, Camus-Bouclainville Christelle, Jacqueline Gelfi, Sophie Blanié, Bertagnoli Stéphane, Blanié, Sophie, Gelfi, Jacqueline, Blanié Sophie, Christelle Camus-Bouclainville, Stéphane Bertagnoli, Bertagnoli, Stéphane, Gelfi Jacqueline   +11 more
core   +1 more source

Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]

, 2012
Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175), Majzoub Monir, Sutter Gerd, Kay-Martin Hanschmann (181170), Yasemin Suezer, Kalinke Ulrich, Suezer, Yasemin, Monir Majzoub (181167), Yasemin Suezer (181158), Hanschmann Kay-Martin, Theresa Frenz, Melanie Kremer (181155), Michael H. Lehmann (181173), Lehmann Michael H., Suezer Yasemin, Michael H. Lehmann, Volz Asisa, Asisa Volz (181161), Kay-Martin Hanschmann, Michael H Lehmann, Kremer, Melanie, Asisa Volz, Ulrich Kalinke, Hanschmann, Kay-Martin, Kremer Melanie, Kalinke, Ulrich, Theresa Frenz (181164), Monir Majzoub, Sutter, Gerd, Melanie Kremer, Frenz, Theresa, Ulrich Kalinke (41173), Frenz Theresa, Gerd Sutter, Lehmann, Michael H, Volz, Asisa, Majzoub, Monir, Lehmann, Michael H.   +37 more
core   +1 more source

Poxvirus pathogenesis

Microbiological Reviews, 1991
Poxviruses are a highly successful family of pathogens, with variola virus, the causative agent of smallpox, being the most notable member. Poxviruses are unique among animal viruses in several respects. First, owing to the cytoplasmic site of virus replication, the virus encodes many enzymes required either for macromolecular precursor pool regulation
R M, Buller, G J, Palumbo
openaire   +2 more sources

Poxvirus encoded eIF2α homolog, K3 family proteins, is a key determinant of poxvirus host species specificity.

Virology, 2020
Protein kinase R plays a key role in innate antiviral immune responses of vertebrate animals. Most mammalian poxviruses encode two PKR antagonists, E3 (dsRNA binding) and K3 (eIF2α homolog) proteins.
Jingxin Cao, Jessie Varga, Yvon Deschambault   +2 more
semanticscholar   +1 more source

A Phylogeographic Investigation of African Monkeypox

Viruses, 2015
Monkeypox is a zoonotic disease caused by a virus member of the genus Orthopoxvirus and is endemic to Central and Western African countries. Previous work has identified two geographically disjuct clades of monkeypox virus based on the analysis of a few ...
Yoshinori Nakazawa, Matthew R. Mauldin, Ginny L. Emerson, Mary G. Reynolds, R. Ryan Lash, Jinxin Gao, Hui Zhao, Yu Li, Jean-Jacques Muyembe, Placide Mbala Kingebeni, Okito Wemakoy, Jean Malekani, Kevin L. Karem, Inger K. Damon, Darin S. Carroll   +14 more
doaj   +1 more source

Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research

Viruses, 2017
Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource ...
Mary G. Reynolds, Andrea M. McCollum, Beatrice Nguete, Robert Shongo Lushima, Brett W. Petersen   +4 more
doaj   +1 more source

Modeling enzootic raccoon rabies from land use patterns - Georgia (USA) 2006-2010 [v1; ref status: indexed, http://f1000r.es/2i3]

F1000Research, 2013
We analyzed how land-use patterns and changes in urbanization influence reported rabid raccoons in Georgia from 2006 - 2010.  Using Geographical Information Systems and rabies surveillance data, multivariate analysis was conducted on 15 land-use ...
John E. Duke, Jesse D. Blanton, Melissa Ivey, Charles Rupprecht   +3 more
doaj   +1 more source

Rapid poxvirus engineering using CRISPR/Cas9 as a selection tool

Communications Biology, 2020
In standard uses of CRISPR/Cas9 technology, the cutting of genomes and their efficient repair are considered to go hand-in-hand to achieve desired genetic changes. This includes the current approach for engineering genomes of large dsDNA viruses. However,
Anjali Gowripalan, Stewart A. Smith, T. Stefanovic, D. Tscharke   +3 more
semanticscholar   +1 more source

A Poxvirus in a Marsupial Papilloma

Journal of General Virology, 1972
We wish to present some evidence for the implication of an as yet uncharacterized member of the pox group of viruses in producing epidermal papillomata in a marsupial, Setonix brachyurus. Generally neoplasms in marsupials have not been investigated in any great detail (Barker, Calaby & Sharman, 1963), and it is interesting that in the population of S ...
Papadimitriou, J. M., Ashman, R. B.
openaire   +4 more sources