Results 51 to 60 of about 16,870 (170)

Pietro Verri: The History of Smallpox Vaccination Through His Pencil

JEADV Clinical Practice, EarlyView.
ABSTRACT The last case of natural smallpox infection occurred in 1977, and the disease is considered eradicated since 1980. Throughout the history of medicine, early attempts to combat smallpox involved inoculation, a practice based on the observation that those who recovered from the disease became immune.
Omar Simonetti, Anna Maria Salvadè, Verena Zerbato, Ivo Maria Crosato, Stefano Di Bella, Francesco Bellinato   +5 more
wiley   +1 more source

Investigation of the Efficacy and Safety of TO‐208 in Patients 2 Years of Age or Older With Molluscum Contagiosum in Japan: A Randomized, Double‐Blind, Placebo‐Controlled, Phase 3 Study (208‐3‐1) and Its Open‐Label Extension

The Journal of Dermatology, EarlyView.
ABSTRACT Molluscum contagiosum (MC) is a common viral skin infection in children. In the two Phase 3 Cantharidin Application in Molluscum Patients [CAMP‐1 and CAMP‐2] studies, cantharidin, a drug‐device combination containing cantharidin (0.7%), a topical vesicant, was significantly superior to placebo in achieving complete clearance of MC lesions at ...
Takafumi Kadono, Tsuyoshi Mitsuishi, Akira Shimizu, Yasushi Suga, Daisuke Watanabe, Shinya Kaneko, Ryota Ishiwata, Thomas F. Haws, Susan Cutler, Atsuyuki Igarashi   +9 more
wiley   +1 more source

Zoonotic Poxviruses Associated with Companion Animals

Animals, 2011
Understanding the zoonotic risk posed by poxviruses in companion animals is important for protecting both human and animal health. The outbreak of monkeypox in the United States, as well as current reports of cowpox in Europe, point to the fact that ...
Mary G. Reynolds, Danielle M. Tack
doaj   +1 more source

TNF Decoy Receptors Encoded by Poxviruses

Pathogens, 2021
Tumour necrosis factor (TNF) is an inflammatory cytokine produced in response to viral infections that promotes the recruitment and activation of leukocytes to sites of infection.
Francisco Javier Alvarez-de Miranda, Isabel Alonso-Sánchez, Antonio Alcamí, Bruno Hernaez   +3 more
doaj   +1 more source

Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer

Cancer Science, EarlyView.
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang, Puyuan Chen, Yawen Zheng, Feiyue Shi, Min Wang, Luwei Xu, Xiaowei Wei, Xiumei Wang   +7 more
wiley   +1 more source

Poxvirus vector-based HIV vaccines

, 2010
PURPOSE OF REVIEW: In this review, we will provide the scientific rationale for the use of poxvirus vectors in the field of HIV vaccines, the immunological profile of the vaccine-induced immune responses, an update on the current use of poxvirus vector ...
Jacobs, B., Esteban, M., Mariano Esteban, Giuseppe Pantaleo, Bertram Jacobs, Tartaglia, J., Jim Tartaglia, Pantaleo, G., Esteban M, Jacobs B, Tartaglia J, Pantaleo G   +11 more
core   +1 more source

Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]

, 2012
Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175), Majzoub Monir, Sutter Gerd, Kay-Martin Hanschmann (181170), Yasemin Suezer, Kalinke Ulrich, Suezer, Yasemin, Monir Majzoub (181167), Yasemin Suezer (181158), Hanschmann Kay-Martin, Theresa Frenz, Melanie Kremer (181155), Michael H. Lehmann (181173), Lehmann Michael H., Suezer Yasemin, Michael H. Lehmann, Volz Asisa, Asisa Volz (181161), Kay-Martin Hanschmann, Michael H Lehmann, Kremer, Melanie, Asisa Volz, Ulrich Kalinke, Hanschmann, Kay-Martin, Kremer Melanie, Kalinke, Ulrich, Theresa Frenz (181164), Monir Majzoub, Sutter, Gerd, Melanie Kremer, Frenz, Theresa, Ulrich Kalinke (41173), Frenz Theresa, Gerd Sutter, Lehmann, Michael H, Volz, Asisa, Majzoub, Monir, Lehmann, Michael H.   +37 more
core   +2 more sources

The First Report of Cod Gill Poxvirus in Gills of Atlantic Cod (Gadus morhua L.) Suffering From Cardiorespiratory Disease

Journal of Fish Diseases, Volume 48, Issue 4, April 2025.
ABSTRACT Atlantic cod farming experiences renewed growth in Norway, and increased awareness is essential to address emerging diseases in this species. There are few reports on gill diseases in cod, and to date, no viral gill infections of cod have been documented. In this study, we collected samples from three sequential time points in summer 2023 from
Mona C. Gjessing, Torstein Tengs, Hanne Nilsen, Saima Mohammad, Simon C. Weli   +4 more
wiley   +1 more source

Assessing Monkeypox Virus Prevalence in Small Mammals at the Human–Animal Interface in the Democratic Republic of the Congo

Viruses, 2017
During 2012, 2013 and 2015, we collected small mammals within 25 km of the town of Boende in Tshuapa Province, the Democratic Republic of the Congo. The prevalence of monkeypox virus (MPXV) in this area is unknown; however, cases of human infection were ...
Jeffrey B. Doty, Jean M. Malekani, Lem’s N. Kalemba, William T. Stanley, Benjamin P. Monroe, Yoshinori U. Nakazawa, Matthew R. Mauldin, Trésor L. Bakambana, Tobit Liyandja Dja Liyandja, Zachary H. Braden, Ryan M. Wallace, Divin V. Malekani, Andrea M. McCollum, Nadia Gallardo-Romero, Ashley Kondas, A. Townsend Peterson, Jorge E. Osorio, Tonie E. Rocke, Kevin L. Karem, Ginny L. Emerson, Darin S. Carroll   +20 more
doaj   +1 more source

Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread

Viruses, 2020
Although orthopoxviruses (OPXV) are known to encode a majority of the genes required for replication in host cells, genome-wide genetic screens have revealed that several host pathways are indispensable for OPXV infection.
Susan Realegeno, Lalita Priyamvada, Amrita Kumar, Jessica B. Blackburn, Claire Hartloge, Andreas S. Puschnik, Suryaprakash Sambhara, Victoria A. Olson, Jan E. Carette, Vladimir Lupashin, Panayampalli Subbian Satheshkumar   +10 more
doaj   +1 more source