Results 51 to 60 of about 24,392 (225)

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity [PDF]

, 2013
Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity.
Benfield, C T O, De Motes, C M, Ember, S W J, Ferguson, B J, Mazzon, M, Smith, G L, Sumner, R P   +6 more
core   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

What is rural? Examining the relationship between human populations and their inter-connectedness in the context of communicable disease transmission

International Journal of Health Geographics
Background Rurality and urbanicity are recognized determinants of public health outcomes that influence policy and resource allocation. However, many commonly used methods to classify the rural-urban continuum, such as the Rural-Urban Commuting Area ...
Cassandra Boutelle, Patrick Corbett, Andrew Gibson, Frederic Lohr, Catherine Swedberg, Jesse Blanton, Ryan Wallace   +6 more
doaj   +1 more source

Cowpox virus: What’s in a Name?

Viruses, 2017
Traditionally, virus taxonomy relied on phenotypic properties; however, a sequence-based virus taxonomy has become essential since the recent requirement of a species to exhibit monophyly.
Matthew R. Mauldin, Markus Antwerpen, Ginny L. Emerson, Yu Li, Gudrun Zoeller, Darin S. Carroll, Hermann Meyer   +6 more
doaj   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

POXVIRUS DISEASE OF SQUIRRELS (POXVIRIDAE, CHORDOPOXVIRINAE, SQPV - SQUIRREL POXVIRUS)

Problems of Virology, 2018
A new taxon of the subfamily Chordopoxvirinae that may represent a new genus of smallpox viruses is considered in this review. The distribution of gray squirrels (Sciurus carolinensis) throughout the UK during the 20th century and the decrease in the population of red squirrels (Sciurus vulgaris) is one of the most well-documented cases of ecological ...
S. V. Borisevich, L. F. Stovba, D. I. Paveliev   +2 more
openaire   +4 more sources

Assessing Monkeypox Virus Prevalence in Small Mammals at the Human–Animal Interface in the Democratic Republic of the Congo

Viruses, 2017
During 2012, 2013 and 2015, we collected small mammals within 25 km of the town of Boende in Tshuapa Province, the Democratic Republic of the Congo. The prevalence of monkeypox virus (MPXV) in this area is unknown; however, cases of human infection were ...
Jeffrey B. Doty, Jean M. Malekani, Lem’s N. Kalemba, William T. Stanley, Benjamin P. Monroe, Yoshinori U. Nakazawa, Matthew R. Mauldin, Trésor L. Bakambana, Tobit Liyandja Dja Liyandja, Zachary H. Braden, Ryan M. Wallace, Divin V. Malekani, Andrea M. McCollum, Nadia Gallardo-Romero, Ashley Kondas, A. Townsend Peterson, Jorge E. Osorio, Tonie E. Rocke, Kevin L. Karem, Ginny L. Emerson, Darin S. Carroll   +20 more
doaj   +1 more source

Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus [PDF]

, 1998
Recently, myxoma virus was shown to encode an additional member of the serpin superfamily. The viral gene, called serp2, was cloned, and the Serp2 protein was shown to specifically bind to interleukin-1beta (IL-1beta)-converting enzyme (ICE), thus ...
Messud-Petit, Frédérique, Gelfi, Jacqueline, Delverdier, Maxence, Amardeilh, Marie France, Py, Robert, Sutter, Gerd, Bertagnoli, Stéphane   +6 more
core  

Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family. [PDF]

, 2015
Vaccinia virus (VACV) encodes several proteins that inhibit activation of the proinflammatory transcription factor nuclear factor κB (NF-κB). VACV protein A49 prevents translocation of NF-κB to the nucleus by sequestering cellular β-TrCP, a protein ...
Graham, Stephen C, Maluquer de Motes, Carlos, Mansur, Daniel S, Neidel, Sarah, Smith, Geoffrey L, Strnadova, Pavla   +5 more
core   +1 more source

Salt Treatment Confers Protection Against Acute Carp Edema Virus Reinfection While Promoting Viral Persistence

Journal of Fish Diseases, EarlyView.
ABSTRACT Carp edema virus (CEV) infects the common carp (Cyprinus carpio) and causes the lethal koi sleepy disease (KSD). Signs of KSD include respiratory, detoxification, and osmoregulatory difficulties. Salt treatment re‐equilibrates blood sodium levels and can save the fish. However, it is unclear whether these fish are immunized, remain chronically
Mikolaj Adamek, Maria Zawisza, Justin Tze Ho Chan, Alexander Rebl, Felix Teitge, Alberto Falco, Anne‐Carina Miebach, Verena Jung‐Schroers, Esteban Soto, Jiří Kyslík, Dieter Steinhagen, Krzysztof Rakus, Tomas Korytar   +12 more
wiley   +1 more source