ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi +6 more
wiley +1 more source
Use of poxvirus display to select antibodies specific for complex membrane antigens
Antibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs and into ...
Ernest S. Smith +21 more
doaj +1 more source
Clinical and computed tomography findings of fatal poxviral vasculitis in a domestic shorthair cat
Abstract This report describes the clinical presentation, haematological abnormalities and imaging findings of systemic poxvirus infection in a cat that resulted in widespread severe dermal oedema and systemic inflammatory response syndrome. The cat lacked cutaneous lesions before the onset of dermal oedema, but developed crusting skin lesions and a ...
Mica Taylor +5 more
wiley +1 more source
Poxvirus Orthologous Clusters: toward Defining the Minimum Essential Poxvirus Genome [PDF]
ABSTRACT Increasingly complex bioinformatic analysis is necessitated by the plethora of sequence information currently available. A total of 21 poxvirus genomes have now been completely sequenced and annotated, and many more genomes will be available in the next few years.
Chris, Upton +4 more
openaire +2 more sources
Dual Use Research of Concern—The Necessity of Global Bioethics Engagement
ABSTRACT Dual use research of concern (DURC) refers to research conducted for legitimate scientific purposes that could also be misused to pose a significant threat to public health and safety, agricultural crops and other plants, animals, the environment, or national security.
Daniel J. Hurst, Christopher A. Bobier
wiley +1 more source
Mpox in South Asia: A Narrative Review on Epidemiology, Preparedness, and Preventive Strategies
ABSTRACT Background and Aims Monkeypox (Mpox), due to its growing global concern, was declared a public health emergency of worldwide concern by the World Health Organization in August 2024. The monkeypox virus (MPXV), once limited to African regions, has now spread to South Asia, including Pakistan, India, Nepal, and Sri Lanka, and there have been ...
Jannatul Mawa +5 more
wiley +1 more source
What If Trojan Horse Nanoparticles Could Change the Game for HPV Gene‐Targeted Therapies?
ABSTRACT Human papillomavirus (HPV) is a common sexually transmitted infection linked to various cancers, particularly cervical cancer, primarily driven by high‐risk strains like HPV16 and HPV18. While vaccines are effective in preventing new infections, they do not address existing cases, highlighting the need for innovative therapies.
Trairong Chokwassanasakulkit +4 more
wiley +1 more source
Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques [PDF]
Background A DNA prime, poxvirus (COPAK) boost vaccination regime with four antigens, i.e. a combination of two Plasmodium knowlesi sporozoite (csp/ssp2) and two blood stage (ama1/msp1 42 ) genes ...
Muzamil Mahdi Abdel Hamid +8 more
core +2 more sources
Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin +10 more
wiley +1 more source
DNA Virus Detection in Olfactory Neuroblastomas Using Targeted Enrichment NGS
ABSTRACT A variety of malignancies can be found in the sinonasal tract including the nasal cavity, paranasal sinuses, and skull base. Many of these are attributed to viruses, for example, carcinomas with the presence of transcriptionally active high‐risk human papillomavirus, as well as Epstein–Barr virus associated malignant lymphoepithelial carcinoma
Maria K. Jauhiainen +7 more
wiley +1 more source

