Results 91 to 100 of about 24,392 (225)

The Origin and Evolution of Viruses as Molecular Organisms [PDF]

, 2009
Viruses are the most abundant life forms and the repertoire of viral genes is greater than that of cellular genes. It is also evident that viruses have played a major role in driving cellular evolution, and yet, viruses are not part of mainstream biology,
Claudiu I. Bandea
core   +2 more sources

Immune modulation by virus-encoded secreted chemokine binding proteins [PDF]

, 2015
Chemokines are chemoattractant cytokines that mediate the migration of immune cells to sites of infection which play an important role in innate and adaptive immunity. As an immune evasion strategy, large DNA viruses (herpesviruses and poxviruses) encode
Alcamí, Antonio, Heidarieh, Haleh, Hernáez, Bruno   +2 more
core   +1 more source

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer‐Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice

MedComm, Volume 7, Issue 2, February 2026.
We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Cong Tang, Longhai Yuan, Yun Xie, Yun Yang, Yanan Zhou, Junbing Wang, Hao Yang, Rui Peng, Jiali Xu, Wenhai Yu, Qing Huang, Wenqi Quan, Baisheng Li, Youchun Wang, Shuaiyao Lu   +14 more
wiley   +1 more source

Epithelial Immunization Induces Polyfunctional CD8+ T Cells and Optimal Mousepox Protection. [PDF]

, 2014
We assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest protection. Humoral immunity and resident-memory T cells notwithstanding,
A. E. Snook, A. R. Hersperger, B. C. DeHaven, Betts, Betts, Buller, Burnet, Earl, Edghill-Smith, Esteban, Fenner, Gebhardt, Hersperger, Hersperger, Hooper, Jiang, L. C. Eisenlohr, Liu, Liu, Makedonas, N. A. Siciliano, Panchanathan, Panchanathan, Panchanathan, Seder, Trentin, Tscharke, Xu   +27 more
core   +2 more sources

Mathematical Modeling of the Role of Cytokines in Sindbis Virus Treatment of Glioblastoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Oncolytic viruses, specifically Sindbis virus (SINV), combined with cytokines show promising results in slowing glioma progression, but a quantitative understanding of their effects remains limited. In this study, we use an ordinary differential equation (ODE) model to examine the effect of adding cytokines to oncolytic SINV therapy.
Shriya Makam, Hana M. Dobrovolny
wiley   +1 more source

A System Based-Approach to Examine Cytokine Response in Poxvirus-Infected Macrophages

Viruses, 2018
The poxviruses are large, linear, double-stranded DNA viruses about 130 to 230 kbp, that have an animal origin and evolved to infect a wide host range.
Pui-San Wong, Richard Sutejo, Hui Chen, Sock-Hoon Ng, Richard J. Sugrue, Boon-Huan Tan   +5 more
doaj   +1 more source

Papular-purpuric gloves-and-socks syndrome. Presentation of a clinical case [PDF]

, 2007
Papular-Purpuric Glove-and-Sock Syndrome is a rare, infectious disease, of viral etiology, characterized by the presence of pruritus, edema and symmetrical erythema, very well defined at the wrists and ankles with a gloves-and-socks distribution.
Martínez-Sahuquillo Márquez, Ángel
core  

Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy [PDF]

, 2014
BACKGROUND: PROSTVAC®, an active immunotherapy currently studied for the treatment of metastatic castration-resistant prostate cancer (mCRPC), consists of a heterologous prime-boost regimen with two different poxvirus-based vectors to provoke productive ...
Alain Delcayre, Alex Franzusoff, Erica Trent, Evan J Gordon, Joseph J Cote, Ryan B Rountree, Stefanie J Mandl, Susan P Foy, Tracy B dela Cruz   +8 more
core   +2 more sources

Infections humaines à poxvirus

Annales de Dermatologie et de Vénéréologie, 2019
Poxvirus (PXV) infections are a common cause of cutaneous signs. In France, certain forms of poxvirus are frequent and benign (molluscum contagiosum), while others are rare but potentially serious (cowpox virus [CPXV]). Whereas only smallpox and molluscum contagiosum viruses have a human reservoir and are transmitted between humans, most poxvirus ...
Bohelay, G., Duong, T.-A.
openaire   +2 more sources

Genome Variability and Gene Content in Chordopoxviruses: Dependence on Microsatellites

Viruses, 2015
To investigate gene loss in poxviruses belonging to the Chordopoxvirinae subfamily, we assessed the gene content of representative members of the subfamily, and determined whether individual genes present in each genome were intact, truncated, or ...
Eneida L. Hatcher, Chunlin Wang, Elliot J. Lefkowitz   +2 more
doaj   +1 more source