Results 11 to 20 of about 57,005 (244)

Challenges and Achievements in Prevention and Treatment of Smallpox

Vaccines, 2018
Declaration of smallpox eradication by the WHO in 1980 led to discontinuation of the worldwide vaccination campaign. The increasing percentage of unvaccinated individuals, the existence of its causative infectious agent variola virus (VARV), and the ...
Sharon Melamed, Tomer Israely, Nir Paran
doaj   +1 more source

Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread

Viruses, 2020
Although orthopoxviruses (OPXV) are known to encode a majority of the genes required for replication in host cells, genome-wide genetic screens have revealed that several host pathways are indispensable for OPXV infection.
Susan Realegeno, Lalita Priyamvada, Amrita Kumar, Jessica B. Blackburn, Claire Hartloge, Andreas S. Puschnik, Suryaprakash Sambhara, Victoria A. Olson, Jan E. Carette, Vladimir Lupashin, Panayampalli Subbian Satheshkumar   +10 more
doaj   +1 more source

A Global Health Alert on the Re-Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus. Mpox was first detected in the 1970s and mostly affects Central and West Africa.
Aqeel MB, Hanif A, Ahmad S, Shah FI, Javed B, Javed B, Iqbal S.   +6 more
europepmc   +2 more sources

Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants? [PDF]

, 2010
Background: Vaccinia virus strain Lister Elstree (VACV) is a test virus in the DVV/RKI guidelines as representative of the stable enveloped viruses.
Jochen Steinmann, Rapp, Ingrid, Ingrid Rapp, Rabenau, Holger, Steinmann Jochen, Holger F Rabenau, Steinmann, Jochen, Rabenau Holger F, Rapp Ingrid   +8 more
core   +1 more source

Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine

Vaccines, 2020
Background: Vaccinia is known to induce antibody and cellular responses. Plasmablast, circulating follicular helper T (cTFH) cells, cytokine-expressing CD4 T cells, and memory B cells were compared between subcutaneous (SC) and needle-free jet injection (
Evan J. Anderson, Lilin Lai, Jens Wrammert, Sarah Kabbani, Yongxian Xu, Lalita Priyamvada, Heather Hill, Johannes B. Goll, Travis L. Jensen, Carol Kao, Inci Yildirim, Nadine Rouphael, Lisa Jackson, Mark J. Mulligan   +13 more
doaj   +1 more source

Vaccinia Virus Infection Requires Maturation of Macropinosomes. [PDF]

, 2015
The prototypic poxvirus, vaccinia virus (VACV), occurs in two infectious forms, mature virions (MVs) and extracellular virions (EVs). Both enter HeLa cells by inducing macropinocytic uptake.
Mercer, Jason, Rizopoulos, Zaira, Balistreri, G, Kilcher, S, Mercer, J, Syedbasha, M, Kilcher, Samuel, Helenius, Ari, Balistreri, Giuseppe, Rizopoulos, Z, Syedbasha, Mohammedyaseen, Martin, Caroline K., Martin, CK, Helenius, A   +13 more
core   +1 more source

The Virology of Taterapox Virus In Vitro

Viruses, 2018
Taterapox virus (TATV) is phylogenetically the closest related virus to variola—the etiological agent of smallpox. Despite the similarity, few studies have evaluated the virus.
Scott Parker, Leonardo Camilo de Oliveira, Elliot J. Lefkowitz, Robert Curtis Hendrickson, Cláudio A. Bonjardim, William S. M. Wold, Hollyce Hartzler, Ryan Crump, Robert Mark Buller   +8 more
doaj   +1 more source

Transcriptional reprogramming of natural killer cells by vaccinia virus shows both distinct and conserved features with mCMV

Frontiers in Immunology, 2023
Natural killer (NK) cells have an established role in controlling poxvirus infection and there is a growing interest to exploit their capabilities in the context of poxvirus-based oncolytic therapy and vaccination.
Delphine M. Depierreux, Geoffrey L. Smith, Brian J. Ferguson   +2 more
doaj   +1 more source

Neutralization Determinants on Poxviruses

Viruses, 2023
Smallpox was a highly contagious disease caused by the variola virus. The disease affected millions of people over thousands of years and variola virus ranked as one of the deadliest viruses in human history. The complete eradication of smallpox in 1980,
Vernuccio Riccardo, Guardado-Calvo Pablo
doaj   +1 more source

Complete regression of cutaneous metastases with systemic immune response in a patient with triple negative breast cancer receiving p53MVA vaccine with pembrolizumab

OncoImmunology, 2017
A heavily pretreated patient with triple negative breast cancer distinguished by cutaneous metastases received p53MVA vaccine in combination with pembrolizumab.
Yuan Yuan, Ferdynand J. Kos, Ting-Fang He, Hongwei H. Yin, Mengsha Li, Nicola Hardwick, Kathryn Zurcher, Daniel Schmolze, Peter Lee, Raju K. Pillai, Vincent Chung, Don J. Diamond   +11 more
doaj   +1 more source