Results 11 to 20 of about 84,745 (238)

When good vaccines go wild: Feral Orthopoxvirus in developing countries and beyond

Journal of Infection in Developing Countries, 2008
The presence of zoonotic poxviruses in nature represents a potential human health risk that has to be re-evaluated by health authorities not only in developing countries, but also in many developed countries.
Nissin Moussatché,1,2 Clarissa R. Damaso,2 and Grant McFadden1
doaj   +3 more sources

Challenges and Achievements in Prevention and Treatment of Smallpox

Vaccines, 2018
Declaration of smallpox eradication by the WHO in 1980 led to discontinuation of the worldwide vaccination campaign. The increasing percentage of unvaccinated individuals, the existence of its causative infectious agent variola virus (VARV), and the ...
Sharon Melamed, Tomer Israely, Nir Paran
doaj   +1 more source

Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread

Viruses, 2020
Although orthopoxviruses (OPXV) are known to encode a majority of the genes required for replication in host cells, genome-wide genetic screens have revealed that several host pathways are indispensable for OPXV infection.
Susan Realegeno, Lalita Priyamvada, Amrita Kumar, Jessica B. Blackburn, Claire Hartloge, Andreas S. Puschnik, Suryaprakash Sambhara, Victoria A. Olson, Jan E. Carette, Vladimir Lupashin, Panayampalli Subbian Satheshkumar   +10 more
doaj   +1 more source

The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility [PDF]

, 2013
Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs).
Alberts, Alvarez, Arakawa, Bagrodia, Bernardini, Block, Boujemaa-Paterski, Chong, Chong, Diego E. Alvarez, Earl, Engelstad, Feig, Frischknecht, Fukuoka, Gasteier, Goldberg, Haglund, Hannemann, Harris, Harris, Heindl, Hervé Agaisse, Hiller, Hollinshead, Hoppe, Humphries, Isaacs, Katz, Kleba, Koka, Kovar, Krall, Lammers, Lasa, Li, Madrid, Moseley, Moseley, Newsome, Newsome, Nezami, Otomo, Parkinson, Pollard, Pring, Pruyne, Qiu, Ridley, Rietdorf, Roberts, Rolls, Romero, Röttger, Sanderson, Scaplehorn, Schmelz, Schulte, Schönichen, Schönichen, Serio, Shibata, Siripala, Skoble, Smith, Suzuki, Takeya, Tooze, van Eijl, van Eijl, Wallar, Ward, Ward, Watanabe, Weisswange, Welch, Westendorf, Westendorf, Wolffe, Wolffe   +79 more
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Single Dose of Recombinant Chimeric Horsepox Virus (TNX-801) Vaccination Protects Macaques from Lethal Monkeypox Challenge

Viruses, 2023
The ongoing global Monkeypox outbreak that started in the spring of 2022 has reinforced the importance of protecting the population using live virus vaccines based on the vaccinia virus (VACV).
Ryan S. Noyce, Landon W. Westfall, Siobhan Fogarty, Karen Gilbert, Onesmo Mpanju, Helen Stillwell, José Esparza, Bruce Daugherty, Fusataka Koide, David H. Evans, Seth Lederman   +10 more
doaj   +1 more source

Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus [PDF]

, 1975
VARIOUS virus infections lead to the formation of cytotoxic lymphocytes (CL), which are capable of killing virus-infected target cells1−4. Specific lysis of target cells infected with 51Cr-labelled vaccinia virus could be observed when investigating the ...
GJ Hämmerling, GM Shearer, H. ERTL, HR McFarland, I Gardner, LF Speel, M Nabholz, M Schlesinger, O Marker, RM Zinkernagel, RM Zinkernagel, RM Zinkernagel, RV Blanden, U. KOSZINOWSKI   +13 more
core   +1 more source

Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine

Vaccines, 2020
Background: Vaccinia is known to induce antibody and cellular responses. Plasmablast, circulating follicular helper T (cTFH) cells, cytokine-expressing CD4 T cells, and memory B cells were compared between subcutaneous (SC) and needle-free jet injection (
Evan J. Anderson, Lilin Lai, Jens Wrammert, Sarah Kabbani, Yongxian Xu, Lalita Priyamvada, Heather Hill, Johannes B. Goll, Travis L. Jensen, Carol Kao, Inci Yildirim, Nadine Rouphael, Lisa Jackson, Mark J. Mulligan   +13 more
doaj   +1 more source

Possible Mpox Protection from Smallpox Vaccine–Generated Antibodies among Older Adults

Emerging Infectious Diseases, 2023
Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71–80 years of age.
Iván Sanz-Muñoz, Laura Sánchez-dePrada, Javier Sánchez-Martínez, Silvia Rojo-Rello, Marta Domínguez-Gil, Cristina Hernán-García, Virginia Fernández-Espinilla, Raúl Ortiz de Lejarazu-Leonardo, Javier Castrodeza-Sanz, José María Eiros   +9 more
doaj   +1 more source

The Virology of Taterapox Virus In Vitro

Viruses, 2018
Taterapox virus (TATV) is phylogenetically the closest related virus to variola—the etiological agent of smallpox. Despite the similarity, few studies have evaluated the virus.
Scott Parker, Leonardo Camilo de Oliveira, Elliot J. Lefkowitz, Robert Curtis Hendrickson, Cláudio A. Bonjardim, William S. M. Wold, Hollyce Hartzler, Ryan Crump, Robert Mark Buller   +8 more
doaj   +1 more source

Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size [PDF]

, 2015
Modified vaccinia virus Ankara (MVA) is a candidate vaccine vector that is severely attenuated due to mutations acquired during several hundred rounds of serial passage in vitro.
Dobson, Bianca, Tscharke, David C.
core   +1 more source