Results 31 to 40 of about 57,005 (244)

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials [PDF]

, 2007
Objectives. To investigate the safety and immunogenicity of boosting BCG with modified vaccinia Ankara expressing antigen 85A (MVA85A), shortly after BCG vaccination, and to compare this first with the immunogenicity of BCG vaccination alone and second
Whelan, KT, Pathan, Ansar A, Poulton Ian, Nicola C Alder, Sander Clare R., Whelan, Kathryn T, Kathryn T Whelan, Hill, Adrian, Fletcher, Helen A, Natalie E R Beveridge, Hill, AVS, Alder, NC, Fletcher, HA, Pathan Ansar A., Hill, Adrian VS, Sander, CR, Hill Adrian V. S., McShane Helen, Beveridge Natalie E. R., Pathan, AA, Hill, AV, Beveridge, NER, Alder, Nicola C, Clare R Sander, Helen McShane, Ansar A Pathan, Beveridge, NE, Ian Poulton, Poulton, Ian, Alder Nicola C., Whelan Kathryn T., Poulton, I, Sander, Clare R, Adrian V S Hill, Helen A Fletcher, Fletcher Helen A., McShane, H, Beveridge, Natalie ER, Fletcher, Helen, McShane, Helen   +39 more
core   +1 more source

Vaccinia virus replication is not affected by APOBEC3 family members

, 2006
Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd, Kremer Melanie, Schnierle Barbara S, Yasemin Suezer, Suezer, Yasemin, Martinez-Fernandez Yolanda, Schnierle, Barbara, Münk Carsten, Sutter, Gerd, Yolanda Martinez-Fernandez, Melanie Kremer, Barbara S Schnierle, Münk, Carsten, Suezer Yasemin, Gerd Sutter, Martinez-Fernandez, Yolanda, Carsten Münk, Kremer, Melanie   +17 more
core   +1 more source

HUMAN CYTOMEGALOVIRUS-SPECIFIC CYTO-TOXIC T-CELLS - RELATIVE FREQUENCY OF STAGE-SPECIFIC CTL RECOGNIZING THE 72-KD IMMEDIATE EARLY PROTEIN AND GLYCOPROTEIN-B EXPRESSED BY RECOMBINANT VACCINIA VIRUSES [PDF]

, 1988
CTL are held to be an important host defense mechanism in persistent herpes-virus infections. We have therefore studied the nature and specificity of human cytomegalovirus (HCMV)-specific CTL in normal persistently infected individuals. This was achieved
J K Hickling, Smith, GL, Sinclair, J, J G Sissons, Borysiewicz, LK, J Sinclair, S Graham, G L Smith, L K Borysiewicz, Hickling, JK, Sissons, JG, M P Cranage, Cranage, MP, Graham, S   +13 more
core   +1 more source

Single Dose of Recombinant Chimeric Horsepox Virus (TNX-801) Vaccination Protects Macaques from Lethal Monkeypox Challenge

Viruses, 2023
The ongoing global Monkeypox outbreak that started in the spring of 2022 has reinforced the importance of protecting the population using live virus vaccines based on the vaccinia virus (VACV).
Ryan S. Noyce, Landon W. Westfall, Siobhan Fogarty, Karen Gilbert, Onesmo Mpanju, Helen Stillwell, José Esparza, Bruce Daugherty, Fusataka Koide, David H. Evans, Seth Lederman   +10 more
doaj   +1 more source

Vaccinia virus expressing ICP47 : a novel platform for cancer vaccines highlighting tumor epitopes and hiding viral antigens [PDF]

, 2010
Background Recombinant poxviruses expressing tumor associated antigens (TAAs) are evaluated since 20 years as immunogenic vaccine vector in clinical trials.
Raafat, Nermin Abdel Fattah
core   +1 more source

A Quadrivalent mRNA Immunization Elicits Potent Immune Responses against Multiple Orthopoxviral Antigens and Neutralization of Monkeypox Virus in Rodent Models

Vaccines
The global outbreak of the 2022 monkeypox virus infection of humans and the 2023 documentation of a more virulent monkeypox in the Democratic Republic of the Congo raised public health concerns about the threat of human-to-human transmission of zoonotic ...
Caixia Su, Sha Li, Yang Wen, Xiya Geng, Quanyi Yin, Yun Wang, Yelin Xiong, Zhihua Liu   +7 more
doaj   +1 more source

A new inhibitor of apoptosis from vaccinia virus and eukaryotes.

, 2007
A new apoptosis inhibitor is described from vaccinia virus, camelpox virus, and eukaryotic cells. The inhibitor is a hydrophobic, multiple transmembrane protein that is resident in the Golgi and is named GAAP (Golgi anti-apoptotic protein).
Hollinshead, M, Smith, GL, van Kuppeveld, FJM, van Kuppeveld Frank J. M, Lu, X., Smith, G.L., Xin Lu, Gubser, C, Smith Geoffrey L, Bergamaschi, D., Bergamaschi Daniele, Hollinshead Michael, Caroline Gubser, Hollinshead, M., van Kuppeveld, FJ, Bergamaschi, D, Kuppeveld, F.J.M. van, Gubser Caroline, Geoffrey L Smith, Gubser, C., Frank J M van Kuppeveld, Michael Hollinshead, Lu Xin, Daniele Bergamaschi, Lu, Xin, Lu, X   +25 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A Filtration Based Technique for Simultaneous SEM and TEM Sample Preparation for the Rapid Detection of Pathogens

Viruses, 2014
Diagnostic electron microscopy for infectious diseases has the advantage that “everything” in the specimen can be observed, without a priori knowledge of the likely identity of the microorganisms present in the sample.
Daniel R. Beniac, Christine G. Siemens, Christine J. Wright, Tim F. Booth   +3 more
doaj   +1 more source

Possible Mpox Protection from Smallpox Vaccine–Generated Antibodies among Older Adults

Emerging Infectious Diseases, 2023
Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71–80 years of age.
Iván Sanz-Muñoz, Laura Sánchez-dePrada, Javier Sánchez-Martínez, Silvia Rojo-Rello, Marta Domínguez-Gil, Cristina Hernán-García, Virginia Fernández-Espinilla, Raúl Ortiz de Lejarazu-Leonardo, Javier Castrodeza-Sanz, José María Eiros   +9 more
doaj   +1 more source