Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity [PDF]
Emerging Microbes and InfectionsA large outbreak of monkeypox occurred in 2022, and most people lack immunity to orthopoxvirus. Smallpox vaccination is essential for preventing further smallpox outbreaks.
Hao Liu +7 more
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Efficacy and Safety of the Smallpox Vaccine for Postexposure Prophylaxis in Monkeypox: Protocol for an Open-Labeled, Single-Armed Study [PDF]
JMIR Research Protocols, 2023 BackgroundIn May 2022, a case of monkeypox (currently known as “mpox”) with no history of overseas travel was reported in the United Kingdom, followed by reports of infections reported in Europe, the United States, and other ...
Rina Yano +11 more
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Evaluating the Immunogenicity and Safety of a Smallpox Vaccine to Monkeypox in Healthy Japanese Adults: A Single-Arm Study [PDF]
Life, 2023 Monkeypox (mpox) is an acute exanthematous disease caused by the monkeypox virus (MPXV). Since May 2022, patients with mpox have been reported worldwide, mainly in Europe and the Americas.
Noriko Tomita +13 more
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A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine [PDF]
Emerging Microbes and Infections, 2022 Viral vectors are a potent vaccine platform for inducing humoral and T-cell immune responses. Among the various viral vectors, replication-competent ones are less commonly used for coronavirus disease 2019 (COVID-19) vaccine development compared with ...
Akihiko Sakamoto +10 more
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The origins and genomic diversity of American Civil War Era smallpox vaccine strains [PDF]
Genome Biology, 2020 Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination.
Ana T. Duggan +21 more
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Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA [PDF]
Genome Biology, 2020 According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century.
Annika Brinkmann +4 more
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Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects [PDF]
mBio, 2022 Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including progressive vaccinia and postvaccinia encephalitis. As the Dryvax smallpox vaccine consists of
Ruikang Liu +5 more
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From Jenner to genomics: the unfolding future of vaccinology [PDF]
Frontiers in ImmunologyThe development of the smallpox vaccine two centuries ago laid the foundation for modern vaccinology. Smallpox, once a major killer in human history, was eradicated globally in 1980.
Rabab Batool
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ACAM2000™: The new smallpox vaccine for United States Strategic National Stockpile
Drug Design, Development and Therapy, 2010 Aysegul Nalca, Elizabeth E ZumbrunCenter for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, MD, USAAbstract: Smallpox was eradicated more than 30 years ago, but heightened concerns over ...
Aysegul Nalca, Elizabeth E Zumbrun
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Safety and Efficacy of Post-Eradication Smallpox Vaccine as an Mpox Vaccine: A Systematic Review with Meta-Analysis [PDF]
International Journal of Environmental Research and Public Health, 2023 Amal Mitra +2 more
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