Results 11 to 20 of about 448,317 (216)

Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity [PDF]

Emerging Microbes and Infections
A large outbreak of monkeypox occurred in 2022, and most people lack immunity to orthopoxvirus. Smallpox vaccination is essential for preventing further smallpox outbreaks.
Hao Liu, Wenjing Wang, Yang Zhang, Fuchun Wang, Junyi Duan, Tao Huang, Xiaojie Huang, Tong Zhang   +7 more
doaj   +2 more sources

A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine [PDF]

Emerging Microbes and Infections, 2022
Viral vectors are a potent vaccine platform for inducing humoral and T-cell immune responses. Among the various viral vectors, replication-competent ones are less commonly used for coronavirus disease 2019 (COVID-19) vaccine development compared with ...
Akihiko Sakamoto, Hiroaki Osawa, Hinata Hashimoto, Tetsushi Mizuno, Ammar A. Hasyim, Yu-ichi Abe, Yuto Okahashi, Ryohei Ogawa, Mitsuhiro Iyori, Hisatoshi Shida, Shigeto Yoshida   +10 more
doaj   +2 more sources

The origins and genomic diversity of American Civil War Era smallpox vaccine strains [PDF]

Genome Biology, 2020
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination.
Ana T. Duggan, Jennifer Klunk, Ashleigh F. Porter, Anna N. Dhody, Robert Hicks, Geoffrey L. Smith, Margaret Humphreys, Andrea M. McCollum, Whitni B. Davidson, Kimberly Wilkins, Yu Li, Amanda Burke, Hanna Polasky, Lowell Flanders, Debi Poinar, Amogelang R. Raphenya, Tammy T. Y. Lau, Brian Alcock, Andrew G. McArthur, G. Brian Golding, Edward C. Holmes, Hendrik N. Poinar   +21 more
doaj   +2 more sources

Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA [PDF]

Genome Biology, 2020
According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century.
Annika Brinkmann, Aline R. V. Souza, José Esparza, Andreas Nitsche, Clarissa R. Damaso   +4 more
doaj   +2 more sources

Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects [PDF]

mBio, 2022
Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including progressive vaccinia and postvaccinia encephalitis. As the Dryvax smallpox vaccine consists of
Ruikang Liu, Jeffrey L. Americo, Patricia L. Earl, Jack Villani, Catherine A. Cotter, Bernard Moss   +5 more
doaj   +2 more sources

Past and Present Vaccinations in Sweden. [PDF]

Acta Paediatr
Acta Paediatrica, Volume 115, Issue 11, Page 2505-2510, November 2026.
Silfverdal SA.
europepmc   +2 more sources

ACAM2000™: The new smallpox vaccine for United States Strategic National Stockpile

Drug Design, Development and Therapy, 2010
Aysegul Nalca, Elizabeth E ZumbrunCenter for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, MD, USAAbstract: Smallpox was eradicated more than 30 years ago, but heightened concerns over ...
Aysegul Nalca, Elizabeth E Zumbrun
doaj   +1 more source

Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID-19 Pandemic. [PDF]

Acta Paediatr
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Sällberg M.
europepmc   +2 more sources

A Global Perspective of Childhood Vaccinations: Past, Present, and Future-From Smallpox to mRNA. [PDF]

Acta Paediatr
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Alfvén T, Reza T, Sowe A.
europepmc   +2 more sources

The smallpox ghost in Voltaire’s life: inoculation and the origins of vaccine acceptance [PDF]

npj Vaccines
Smallpox shaped eighteenth-century debates on risk, trust, and prevention. Voltaire, marked by the disease throughout his life—the “smallpox ghost”—emerged as a prominent advocate of smallpox inoculation (variolation), a preventive practice that preceded
José Tuells, Stanley A. Plotkin
doaj   +2 more sources