Results 11 to 20 of about 38,009 (210)

Monkeypox vaccine – Current status

open access: yesJournal of Integrative Medicine and Research, 2023
From a long time ago, there have been intermittent outbreaks of the zoonotic disease monkeypox (mpox) throughout Africa. The first case of human mpox was documented in 1970 in rural Congo. Mpox was classified as a Public Health Emergency of International
Brig Ambika Mohanty, Aroop Mohanty
doaj   +1 more source

Low-Temperature Multiple Micro-Dispensing on Microneedles for Accurate Transcutaneous Smallpox Vaccination

open access: yesVaccines, 2022
Smallpox is an acute contagious disease caused by the variola virus. According to WHO guidelines, the smallpox vaccine is administrated by scarification into the epidermis using a bifurcated needle moistened with a vaccine solution.
Sang-Gu Yim   +11 more
doaj   +1 more source

Immunomodulator-based enhancement of anti smallpox immune responses. [PDF]

open access: yesPLoS ONE, 2015
BACKGROUND:The current live vaccinia virus vaccine used in the prevention of smallpox is contraindicated for millions of immune-compromised individuals. Although vaccination with the current smallpox vaccine produces protective immunity, it might result ...
Osmarie Martínez   +9 more
doaj   +1 more source

Multi-epitope mRNA Vaccine Design that Exploits Variola Virus and Monkeypox Virus Proteins for Elicitation of Long-lasting Humoral and Cellular Protection Against Severe Disease

open access: yesJournal of Medical Science, 2022
Human monkeypox represents a relatively underexplored infection that has received increased attention since the reported outbreak in May 2022. Due to its clinical similarities with human smallpox, this virus represents a potentially tremendous health ...
Dženan Kovačić, Adna Salihović
doaj   +1 more source

Construction of a bivalent vaccine against anthrax and smallpox using the attenuated vaccinia virus KVAC103

open access: yesBMC Microbiology, 2021
Background Anthrax and smallpox are high-risk infectious diseases, and considered as potential agents for bioterrorism. To develop an effective countermeasure for these diseases, we constructed a bivalent vaccine against both anthrax and smallpox by ...
Deok Bum Park   +9 more
doaj   +1 more source

Prevention and Treatment of Monkeypox: A Systematic Review of Preclinical Studies

open access: yesViruses, 2022
The outbreak of monkeypox, coupled with the onslaught of the COVID-19 pandemic is a critical communicable disease. This study aimed to systematically identify and review research done on preclinical studies focusing on the potential monkeypox treatment ...
Nurizzati Sudarmaji   +5 more
doaj   +1 more source

Immunogenicity and safety of three consecutive production lots of the non replicating smallpox vaccine MVA: A randomised, double blind, placebo controlled phase III trial [PDF]

open access: yes, 2018
BackgroundModified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. A randomised, double-blind, placebo-controlled phase III clinical trial was conducted to demonstrate the humoral ...
Chaplin, Paul   +12 more
core   +3 more sources

The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication [PDF]

open access: yes, 2011
By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication.
Breman, JG   +6 more
core   +1 more source

Therapeutic Vaccines and Antibodies for Treatment of Orthopoxvirus Infections

open access: yesViruses, 2010
Despite the eradication of smallpox several decades ago, variola and monkeypox viruses still have the potential to become significant threats to public health.
Stuart N. Isaacs, Yuhong Xiao
doaj   +1 more source

The Results of Re-certification of Reference Standard Sample Used for the Examination of Quality Smallpox Vaccines

open access: yesЭпидемиология и вакцинопрофилактика, 2016
The article presents the results of research quality of drugs for the prevention of smallpox during the period from 2007 to 2015 years, where the reference standard uses industry standard of activity, specificity (identification) and necrotic activity of
A. V. Muhacheva   +8 more
doaj   +1 more source

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