Results 21 to 30 of about 61,972 (223)

When good vaccines go wild: Feral Orthopoxvirus in developing countries and beyond

Journal of Infection in Developing Countries, 2008
The presence of zoonotic poxviruses in nature represents a potential human health risk that has to be re-evaluated by health authorities not only in developing countries, but also in many developed countries.
Nissin Moussatché,1,2 Clarissa R. Damaso,2 and Grant McFadden1
doaj   +3 more sources

Challenges and Achievements in Prevention and Treatment of Smallpox

Vaccines, 2018
Declaration of smallpox eradication by the WHO in 1980 led to discontinuation of the worldwide vaccination campaign. The increasing percentage of unvaccinated individuals, the existence of its causative infectious agent variola virus (VARV), and the ...
Sharon Melamed, Tomer Israely, Nir Paran
doaj   +1 more source

Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread

Viruses, 2020
Although orthopoxviruses (OPXV) are known to encode a majority of the genes required for replication in host cells, genome-wide genetic screens have revealed that several host pathways are indispensable for OPXV infection.
Susan Realegeno, Lalita Priyamvada, Amrita Kumar, Jessica B. Blackburn, Claire Hartloge, Andreas S. Puschnik, Suryaprakash Sambhara, Victoria A. Olson, Jan E. Carette, Vladimir Lupashin, Panayampalli Subbian Satheshkumar   +10 more
doaj   +1 more source

Possible Mpox Protection from Smallpox Vaccine–Generated Antibodies among Older Adults

Emerging Infectious Diseases, 2023
Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71–80 years of age.
Iván Sanz-Muñoz, Laura Sánchez-dePrada, Javier Sánchez-Martínez, Silvia Rojo-Rello, Marta Domínguez-Gil, Cristina Hernán-García, Virginia Fernández-Espinilla, Raúl Ortiz de Lejarazu-Leonardo, Javier Castrodeza-Sanz, José María Eiros   +9 more
doaj   +1 more source

Vaccinia virus replication is not affected by APOBEC3 family members [PDF]

, 2006
Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd, Kremer Melanie, Schnierle Barbara S, Yasemin Suezer, Suezer, Yasemin, Martinez-Fernandez Yolanda, Schnierle, Barbara, Münk Carsten, Sutter, Gerd, Yolanda Martinez-Fernandez, Melanie Kremer, Barbara S Schnierle, Münk, Carsten, Suezer Yasemin, Gerd Sutter, Martinez-Fernandez, Yolanda, Carsten Münk, Kremer, Melanie   +17 more
core   +1 more source

Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine

Vaccines, 2020
Background: Vaccinia is known to induce antibody and cellular responses. Plasmablast, circulating follicular helper T (cTFH) cells, cytokine-expressing CD4 T cells, and memory B cells were compared between subcutaneous (SC) and needle-free jet injection (
Evan J. Anderson, Lilin Lai, Jens Wrammert, Sarah Kabbani, Yongxian Xu, Lalita Priyamvada, Heather Hill, Johannes B. Goll, Travis L. Jensen, Carol Kao, Inci Yildirim, Nadine Rouphael, Lisa Jackson, Mark J. Mulligan   +13 more
doaj   +1 more source

The Virology of Taterapox Virus In Vitro

Viruses, 2018
Taterapox virus (TATV) is phylogenetically the closest related virus to variola—the etiological agent of smallpox. Despite the similarity, few studies have evaluated the virus.
Scott Parker, Leonardo Camilo de Oliveira, Elliot J. Lefkowitz, Robert Curtis Hendrickson, Cláudio A. Bonjardim, William S. M. Wold, Hollyce Hartzler, Ryan Crump, Robert Mark Buller   +8 more
doaj   +1 more source

Single Immunization of a Vaccine Vectored by a Novel Recombinant Vaccinia Virus Affords Effective Protection Against Respiratory Syncytial Virus Infection in Cotton Rats

Frontiers in Immunology, 2021
Respiratory syncytial virus (RSV) is a leading cause of respiratory infections worldwide and disease management measures are hampered by the lack of a safe and effective vaccine against the infection.
Marsha S. Russell, Sathya N. Thulasi Raman, Caroline Gravel, Wanyue Zhang, Wanyue Zhang, Annabelle Pfeifle, Annabelle Pfeifle, Wangxue Chen, Gary Van Domselaar, David Safronetz, Michael Johnston, Michael Johnston, Simon Sauve, Lisheng Wang, Michael Rosu-Myles, Michael Rosu-Myles, Jingxin Cao, Xuguang Li, Xuguang Li   +18 more
doaj   +1 more source

Vaccinia Scars Associated with Improved Survival among Adults in Rural Guinea-Bissau [PDF]

, 2006
Background: In urban Guinea-Bissau, adults with a vaccinia scar had better survival but also a higher prevalence of HIV-2 infection. We therefore investigated the association between vaccinia scar and survival and HIV infection in a rural area of Guinea ...
Jensen, Mette Lundsby, Leligdowicz Aleksandra, Maarten Schim van der Loeff, Whittle Hilton, Christine Stabell Benn, Dave, S, Aaby, Peter, Lisse Ida Maria, Roth, Adam, Tim Vincent, Aleksandra Leligdowicz, Schimvan der Loeff, M, Schim van der Loeff, Maarten, Carlos da Costa, Dave, Sangeeta, Ravn, Henrik, Dave Sangeeta, Mette Lundsby Jensen, Sangeeta Dave, Jensen Mette Lundsby, Vincent Tim, Leligdowicz, A, Lisse, Ida Maria, Lisse, IM, Ravn, H, Whittle, Hilton, Ida Maria Lisse, Adam Roth, Whittle, H, Roth Adam, Benn Christine Stabell, Roth, A, Aaby Peter, Leligdowicz, Aleksandra, da Costa Carlos, Henrik Ravn, Peter Aaby, Aaby, P, van der Loeff Maarten Schim, Hilton Whittle, Vincent, Tim, Ravn Henrik, da Costa, Carlos, Jensen, ML, da Costa, C, Vincent, T, Benn, CS, Benn, Christine Stabell   +47 more
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Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants? [PDF]

, 2010
Background: Vaccinia virus strain Lister Elstree (VACV) is a test virus in the DVV/RKI guidelines as representative of the stable enveloped viruses.
Jochen Steinmann, Rapp, Ingrid, Ingrid Rapp, Rabenau, Holger, Steinmann Jochen, Holger F Rabenau, Steinmann, Jochen, Rabenau Holger F, Rapp Ingrid   +8 more
core   +2 more sources