Results 41 to 50 of about 1,046,980 (206)

Designing a smallpox B-cell and T-cell multi-epitope subunit vaccine using a comprehensive immunoinformatics approach

Microbiology Spectrum
Smallpox is a highly contagious human disease caused by the variola virus. Although the disease was eliminated in 1979 due to its highly contagious nature and historical pathogenicity, with a mortality rate of up to 30%, this virus is an important ...
Changqing Yu, Qi Wu, Jiuqing Xin, Qiujuan Yu, Zhixin Ma, Mengzhou Xue, Qingyuan Xu, Chunfu Zheng   +7 more
doaj   +1 more source

Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]

, 2011
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
Rixon, F., Palmarini, M., Ratinier Maxime, Ratinier, Maxime, Golder, Matthew, Nunes, S.F., Alessia Armezzani, Sandro Filipe Nunes, Kathryn Allan, Allan Kathryn, Allan, K., Rixon, Frazer, Golder, M., Allan, Kathryn, Nunes Sandro Filipe, Frazer Rixon, Bayoumy, Amr, Shaw, A., Matthew Golder, Franzoni, G., Caporale Marco, Giulia Franzoni, Golder Matthew, Nunes, Sandro Filipe, Bayoumy Amr, Shaw, Andrew, Amr Bayoumy, Palmarini Massimo, Armezzani, A., Shaw Andrew, Palmarini, Massimo, Ratinier, M., Armezzani, Alessia, Franzoni Giulia, Franzoni, Giulia, Maxime Ratinier, Andrew Shaw, Rixon Frazer, Marco Caporale, Massimo Palmarini, Armezzani Alessia, Bayoumy, A., Caporale, Marco, Caporale, M.   +43 more
core   +1 more source

An Antigenically Atypical Strain of Variola Virus

Journal of General Virology, 1976
The Kuwait-5-67 strain of variola virus, although indistinguishable from variola virus in its other properties, behaved atypically in immuno-diffusion tests with antivaccinia serum. The precipitation line pattern produced was similar to that of cowpox virus but lacked one of the main precipitation bands given by all other strains of variola, alastrim ...
S S, Marennikova, E M, Shelukhina, G R, Matsevich, N A, Habahpasheva   +3 more
openaire   +2 more sources

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Vaccination in pediatric transplantation—General recommendations. A position paper by the European Reference Network TransplantChild

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Infectious diseases remain a leading cause of morbidity and mortality among pediatric transplant recipients, despite significant advances in transplantation management. Vaccination is the most effective strategy to prevent infections; however, its efficacy is hindered in solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT)
Valeria Casotti, Francesco Saglio, Adriana Balduzzi, Peter Barany, Vibeke Brix Christensen, Simona Buelli, Daniele Donà, Maja Klaudel‐Dreszler, Sara Mosca, Andrea Pietrobattista, Michele Pinon, Giusy Ranucci, Lars Wennberg, Lorenzo D'Antiga, ERN TransplantChild Working Group, Claudia Vittori, Manuela Tumino, B. Ruben Brandsema, Lisa Swartling, Silvia Garazzino, Carlo Pace Napoleone, Kai Lehmberg, Isabella Guzzo, Charlotte Roy, Nicola Pradegan, Silvia Simo Nebot, Maria Herthelius, Angelo Mazza, Enrico Aidala, Oleg Godik, Victoria Bordon Cueto De Braem, Marco Busutti, Emily Claire Argento, Marc Garcia Lorenzo, Timo Jahnukainen, Zoryana Ivanyuk   +35 more
wiley   +1 more source

Variola virus, 49 strains, 2926 SNPs (increased).

, 2013
Variola virus, 49 strains, 2926 SNPs (increased).
Wei-Bung Wang (467576), Tao Jiang (28401), Shea Gardner (87450)   +2 more
core   +1 more source

Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim [PDF]

, 2015
Subversion of host cell apoptosis is an important survival strategy for viruses to ensure their own proliferation and survival. Certain viruses express proteins homologous in sequence, structure and function to mammalian pro-survival B-cell lymphoma 2 ...
Marshall, B, Doerflinger, M, Kvansakul, M, Chugh, S, Colman, PM, Caria, S, Puthalakath, H   +6 more
core   +1 more source

In vitro inhibition of monkeypox virus production and spread by Interferon-β

Virology Journal, 2012
Background The Orthopoxvirus genus contains numerous virus species that are capable of causing disease in humans, including variola virus (the etiological agent of smallpox), monkeypox virus, cowpox virus, and vaccinia virus (the prototypical member of ...
Johnston Sara C, Lin Kenny L, Connor John H, Ruthel Gordon, Goff Arthur, Hensley Lisa E   +5 more
doaj   +1 more source

Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.

PLoS Pathogens
Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus.
Todd M Bell, Paul Facemire, Jeremy J Bearss, Jo Lynne Raymond, Jennifer Chapman, Xiankun Zeng, Joshua D Shamblin, Janice A Williams, Douglas W Grosenbach, Dennis E Hruby, Inger K Damon, Arthur J Goff, Eric M Mucker   +12 more
doaj   +1 more source

Are We Prepared in Case of a Possible Smallpox-Like Disease Emergence?

Viruses, 2017
Smallpox was the first human disease to be eradicated, through a concerted vaccination campaign led by the World Health Organization. Since its eradication, routine vaccination against smallpox has ceased, leaving the world population susceptible to ...
Victoria A. Olson, Sergei N. Shchelkunov
doaj   +1 more source