Results 21 to 30 of about 1,368,656 (159)

Multi-epitope mRNA Vaccine Design that Exploits Variola Virus and Monkeypox Virus Proteins for Elicitation of Long-lasting Humoral and Cellular Protection Against Severe Disease

Journal of Medical Science, 2022
Human monkeypox represents a relatively underexplored infection that has received increased attention since the reported outbreak in May 2022. Due to its clinical similarities with human smallpox, this virus represents a potentially tremendous health ...
Dženan Kovačić, Adna Salihović
doaj   +1 more source

Use of the Aerosol Rabbitpox Virus Model for Evaluation of Anti-Poxvirus Agents

Viruses, 2010
Smallpox is an acute disease caused by infection with variola virus that has had historic effects on the human population due to its virulence and infectivity.
Thomas G. Voss, Chad J. Roy
doaj   +1 more source

Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model

mSphere, 2021
Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic.
Christina L. Hutson, Ashley V. Kondas, Mathew R. Mauldin, Jeffrey B. Doty, Irma M. Grossi, Clint N. Morgan, Sharon Dietz Ostergaard, Christine M. Hughes, Yoshinori Nakazawa, Chantal Kling, Brock E. Martin, James A. Ellison, Darin D. Carroll, Nadia F. Gallardo-Romero, Victoria A. Olson   +14 more
doaj   +1 more source

Lipid nanoparticle delivery of unmodified mRNAs encoding multiple monoclonal antibodies targeting poxviruses in rabbits

Molecular Therapy: Nucleic Acids, 2022
Poxviruses are a large and complex family of viruses with members such as monkeypox virus and variola virus. The possibility of an outbreak of monkeypox virus (or a related poxvirus) or the misuse of variola virus justifies the development of ...
Eric M. Mucker, Carolin Thiele-Suess, Patrick Baumhof, Jay W. Hooper   +3 more
doaj   +1 more source

Diagnóstico laboratorial de varíola: III - resultados do terceiro ano de atividades

Revista da Sociedade Brasileira de Medicina Tropical, 1971
Os autores apresentam os resultados obtidos no terceiro ano de atividades do laboratório de Diagnóstico de Varíola, no Instituto Presidente Castello Bran-co, da Fundação Instituto Oswaldo Crus, no Rio de Janeiro.
J. A. Mesquita, H. G. Schatzmayr
doaj   +1 more source

Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans

Viruses, 2022
In the late 1970s, global vaccination programs resulted in the eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to the smallpox-inducing variola virus, was previously endemic only in Sub-Saharan Africa but is currently ...
Barbara S. Schnierle
doaj   +1 more source

ESR and NMR studies provide evidence that phosphatidyl glycerol specifically interacts with poxvirus membranes

Virology Journal, 2010
Background The lung would be the first organ targeted in case of the use of Variola virus (the causative agent of smallpox) as a bioweapon. Pulmonary surfactant composed of lipids (90%) and proteins (10%) is considered the major physiological barrier ...
Perino Julien, Favier Anne-Laure, Crouzier David, Debouzy Jean-Claude   +3 more
doaj   +1 more source

Antiviral Activity of Extracts from Basidiomycetes for Orthopoxviruses

Проблемы особо опасных инфекций, 2012
Carried out was evaluation of the effect of water extracts from basidiomycetes in Vero cell culture on variola virus, and vaccinia virus. Antiviral effect demonstrated Inonotus obliquus (Chaga), befungin and melanin from chaga,
T. V. Teplyakova, L. E. Bulychev, T. A. Kosogova, Zh. B. Ibragimova, I. A. Yurganova, A. S. Kabanov, L. I. Puchkova, N. I. Bormotov, A. V. Bardasheva   +8 more
doaj   +1 more source

Trend and hotspots of research on highly pathogenic pathogens: visual analysis based on bibliometrics and bi-clustering

Zhongguo gonggong weisheng, 2023
ObjectiveTo examine status quo and development trends of research worldwide on highly pathogenic pathogens. MethodsIn this study, highly pathogenic pathogens refered to 29 pathogens classified as pathogens of first category in the List of Human ...
Luona LI, Kunlan ZUO, Lili MA, Huan LIU
doaj   +1 more source

Variola virus, 49 strains, 2926 SNPs (increased).

, 2013
Variola virus, 49 strains, 2926 SNPs (increased).
Wei-Bung Wang (467576), Tao Jiang (28401), Shea Gardner (87450)   +2 more
core   +1 more source