Genetic Mapping in Human Disease [PDF]
Science, 2008 Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide ...
David, Altshuler +2 more
openaire +4 more sources
Association of anti-contagion policies with the spread of COVID-19 in United States
Journal of Public Health Research, 2022 Background: The outbreak of a novel coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or COVID-19, raised worldwide concern.
Ali Faghani +2 more
doaj +1 more source
International Journal of Health Geographics, 2011 Background Geographically weighted Poisson regression (GWPR) was applied to the relation between cervical cancer disease incidence rates in England and socio-economic deprivation, social status and family structure covariates.
Cheng Edith MY +2 more
doaj +1 more source
Disease Mapping via Negative Binomial Regression M-quantiles [PDF]
, 2013 We introduce a semi-parametric approach to ecological regression for disease mapping, based on modelling the regression M-quantiles of a Negative Binomial variable. The proposed method is robust to outliers in the model covariates, including those due to
Chambers, Ray +2 more
core +1 more source
The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem [PDF]
, 2016 Several important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site.
Bansal, Naveen K. +8 more
core +3 more sources
Towards in vivo g-ratio mapping using MRI: unifying myelin and diffusion imaging [PDF]
, 2020 The g-ratio, quantifying the comparative thickness of the myelin sheath encasing an axon, is a geometrical invariant that has high functional relevance because of its importance in determining neuronal conduction velocity.
Callaghan, Martina F. +1 more
core +3 more sources
Mapping the Geographic Distribution of Tungiasis in Sub-Saharan Africa
Tropical Medicine and Infectious Disease, 2020 The geographic distribution of tungiasis is poorly understood, despite the frequent occurrence of the disease in marginalized populations of low socioeconomic status.
Mark A. Deka
doaj +1 more source
A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17 [PDF]
, 2015 Closed breeding populations in the dog in conjunction with advances in gene mapping and sequencing techniques facilitate mapping of autosomal recessive diseases and identification of novel disease-causing variants, often using unorthodox experimental ...
A McKenna +27 more
core +3 more sources
Shrinking the lymphatic filariasis map of Ethiopia: reassessing the population at risk through nationwide mapping [PDF]
, 2015 BACKGROUND Mapping of lymphatic filariasis (LF) is essential for the delineation of endemic implementation units and determining the population at risk that will be targeted for mass drug administration (MDA).
Assefa, Ashenafi +10 more
core +10 more sources
Mapping genes through the use of linkage disequilibrium generated by genetic drift: 'Drift mapping' in small populations with no demographic expansion [PDF]
, 1998 Linkage disequilibrium has been a powerful tool in identifying rare disease alleles in human populations. To date, most research has been directed to isolated populations which have undergone a bottleneck followed by rapid exponential expansion.
Laan, Maris +3 more
core +1 more source