Results 241 to 250 of about 1,145,702 (301)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
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Statistics in Medicine, 2001
AbstractThe analysis of the geographical distribution of disease incidence or prevalence is now of considerable importance for public health workers and epidemiologists alike. Important disease variations often have a spatial expression and so spatial analysis methods are an important additional tool in this connection. In this tutorial I have aimed to
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AbstractThe analysis of the geographical distribution of disease incidence or prevalence is now of considerable importance for public health workers and epidemiologists alike. Important disease variations often have a spatial expression and so spatial analysis methods are an important additional tool in this connection. In this tutorial I have aimed to
openaire +2 more sources
2019
Disease Mapping: From Foundations to Multidimensional Modeling guides the reader from the basics of disease mapping to the most advanced topics in this field. A multidimensional framework is offered that makes possible the joint modeling of several risks patterns corresponding to combinations of several factors, including age group, time period ...
Miguel A. Martinez-Beneito +1 more
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Disease Mapping: From Foundations to Multidimensional Modeling guides the reader from the basics of disease mapping to the most advanced topics in this field. A multidimensional framework is offered that makes possible the joint modeling of several risks patterns corresponding to combinations of several factors, including age group, time period ...
Miguel A. Martinez-Beneito +1 more
openaire +1 more source
Ophthalmic Paediatrics and Genetics, 1992
In this review the authors first give an overview of the general strategies of mapping which differ whether the biochemical (molecular) defect of the disease is known or not. The main problems besides mapping are concerned for the first category with the correlation between mutation and phenotype and for the second, with heterogeneity, genetic vs ...
J, Frézal, J, Kaplan, H, Dollfus
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In this review the authors first give an overview of the general strategies of mapping which differ whether the biochemical (molecular) defect of the disease is known or not. The main problems besides mapping are concerned for the first category with the correlation between mutation and phenotype and for the second, with heterogeneity, genetic vs ...
J, Frézal, J, Kaplan, H, Dollfus
openaire +2 more sources
Statistical Methods in Medical Research, 2005
This article discusses and extends statistical models to jointly analyse the spatial variation of rates of several diseases with common risk factors. We start with a review of methods for separate analyses of diseases, then move to ecological regression approaches, where the rates from one of the diseases enter as surrogate covariates for exposure ...
Held, Leonhard +4 more
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This article discusses and extends statistical models to jointly analyse the spatial variation of rates of several diseases with common risk factors. We start with a review of methods for separate analyses of diseases, then move to ecological regression approaches, where the rates from one of the diseases enter as surrogate covariates for exposure ...
Held, Leonhard +4 more
openaire +2 more sources
Estimation in Bayesian Disease Mapping
Biometrics, 2004SummaryRecent work on Bayesian inference of disease mapping models discusses the advantages of the fully Bayesian (FB) approach over its empirical Bayes (EB) counterpart, suggesting that FB posterior standard deviations of small‐area relative risks are more reflective of the uncertainty associated with the relative risk estimation than counterparts ...
MacNab, Ying C. +3 more
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Reliability-adjusted disease maps
Social Science & Medicine, 1995Bayesian methods for adjusting mortality and morbidity rates to account for variations caused by small numbers are presented. Although such methods produce statistically biased morbidity and mortality rate estimates, these approaches are superior for any applications that depend on a relative ordering of a set of rates because the total error of ...
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