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Modelling risks in disease mapping
Statistical Methods in Medical Research, 2006In this article, we propose a strategy of analysis of mortality data with the aim of providing a guideline for epidemiologists and public health researchers to choose a reasonable model for estimating mortality (or incidence) risks. Maps displaying the crude mortality rates or ratios are usually misleading because of the instability of the estimators ...
Ugarte, M. D. +2 more
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Strategies in complex disease mapping
Current Opinion in Genetics & Development, 2000Dissecting the genetics of common, complex disorders remains one of the great challenges in human genetics. The acceleration of human genome sequence determination, improvements in informatics, large-scale identification of single nucleotide polymorphisms and improvements in scoring technologies have now increased the feasibility of identifying ...
G C, Johnson, J A, Todd
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Linkage Disequilibrium Maps and Disease-Association Mapping
2007Over the last few years, association mapping of disease genes has developed into one of the most dynamic research areas of human genetics. It focuses on identifying functional polymorphisms that predispose to complex diseases. Population-based approaches are concerned with exploiting linkage disequilibrium (LD) between single-nucleotide polymorphism ...
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MAP template controlling Crohn’s disease?
Medical Hypotheses, 2020Crohn's disease is stated to be an immune-mediated disease initiated by Mycobacterium avium subspecies paratuberculosis (MAP) infection within a period of host immunological vulnerability and induced by the widespread prevalence of that organism in the human food chain.
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Mixture models and disease mapping
Statistics in Medicine, 1993AbstractThe analysis and recognition of disease clustering in space and its representation on a map is one of the oldest problems in epidemiology. Some traditional methods of constructing such a map are presented. An alternative approach using mixture models to identify population heterogeneity and map construction within an empirical Bayes framework ...
P, Schlattmann, D, Böhning
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NIMBLE for Bayesian Disease Mapping
Spatial and Spatio-temporal Epidemiology, 2020This tutorial describes the basic implementation of Bayesian hierarchical models for spatial health data using the R package nimble. To quote the nimble R description: A system for writing hierarchical statistical models largely compatible with 'BUGS' and 'JAGS', writing nimbleFunctions to operate models and do basic R-style math, and compiling both ...
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Science, 2016
Alzheimer's Disease Alzheimer's disease (AD) is a chronic neurodegenerative disorder that progresses slowly into dementia and short-term memory loss. AD is thought to be caused by aggregation of Ab and tau proteins in plaques and tangles. Vendruscolo et al. investigated why aberrant protein aggregations are found in some tissues but not in others.
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Alzheimer's Disease Alzheimer's disease (AD) is a chronic neurodegenerative disorder that progresses slowly into dementia and short-term memory loss. AD is thought to be caused by aggregation of Ab and tau proteins in plaques and tangles. Vendruscolo et al. investigated why aberrant protein aggregations are found in some tissues but not in others.
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Gene mapping of ocular diseases
Survey of Ophthalmology, 1992Increasing awareness of the role of genetic factors in the causation of many human eye diseases has made ocular genetics one of the fastest growing areas of ophthalmology. The objective of this paper is to present the basic principles of gene mapping and their application to ophthalmology.
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Onconephrology: The intersections between the kidney and cancer
Ca-A Cancer Journal for Clinicians, 2021Mitchell H Rosner +2 more
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