Results 141 to 150 of about 7,831,583 (247)

Organ-on-chip bridging musculoskeletal disease modeling and precision therapeutic discovery. [PDF]

Trends Biotechnol
Gao Q, Lee ML, Makarczyk M, Chow SK, Bunnell BA, Lin H, Goodman SB.   +6 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

From polygenic risk to functional genomics: a framework for precision gynecological disease modeling. [PDF]

Nat Commun
Khatun M, Tapanainen JS, Salumets A.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Organoids for Metabolic Disease Modeling. [PDF]

J Inherit Metab Dis
Ardisasmita AI, Nieuwenhuis EES, Fuchs SA.   +2 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Expanding the scope of Mycobacterium abscessus reference strains to improve pulmonary disease modeling. [PDF]

Dis Model Mech
Howe RA, Tabor C, Panthi CM, Cheng G, Rimal B, Chen E, Nguyen N, Lamichhane G.   +7 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway

Disease Models & Mechanisms, 2023
Jun-yi Zhu, Jin-Gu Lee, Yulong Fu, Joyce van de Leemput, Patricio E. Ray, Zhe Han   +5 more
doaj   +1 more source

Neuronal differentiation of neuroblastoma cell lines for neurological disease modeling. [PDF]

iScience
Pommerenke C, Hauer V, Eberth S, Werr L, Kallnischkies H, Rand U, Nagel S, Bartenhagen C, Dirks WG, Fischer M, Steenpass L, Wang H.   +11 more
europepmc   +1 more source