Results 261 to 270 of about 659,696 (286)

Modelling plant disease epidemics

European Journal of Plant Pathology, 2003
An epidemic is the progress of disease in time and space. Each epidemic has a structure whose temporal dynamics and spatial patterns are jointly determined by the pathosystem characteristics and environmental conditions. One of the important objectives in epidemiology is to understand such spatio-temporal dynamics via mathematical and statistical ...
A. van Maanen, X.-M. Xu
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Models of mitochondrial disease

2002
Publisher Summary This chapter discusses the molecular mechanisms of disease pathogenesis and describes cell and animal models of respiratory-chain disease. The models that have been developed can be used to address a number of different issues: to demonstrate whether the cause of a given respiratory-chain disease is because of a nuclear or a ...
Danae, Liolitsa, Michael G, Hanna
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Disease model: Fanconi anemia

Trends in Molecular Medicine, 2002
Fanconi anemia (FA) is a chromosomal instability syndrome characterized by the presence of pancytopenia, congenital malformations and cancer predisposition. Six genes associated with this disorder have been cloned, and mice with targeted disruptions of several of the FA genes have been generated. These mouse models display the characteristic FA feature
Jasmine C Y, Wong, Manuel, Buchwald
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Repeat Expansion Disease Models

2018
Repeat expansion disorders are a group of inherited neuromuscular diseases, which are caused by expansion mutations of repeat sequences in the disease-causing genes. Repeat expansion disorders include a class of diseases caused by repeat expansions in the coding region of the genes, producing mutant proteins with amino acid repeats, mostly the ...
Morio, Ueyama, Yoshitaka, Nagai
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Disease model: photoreceptor degenerations

Trends in Molecular Medicine, 2001
Retinal diseases can be caused by genetic or non-genetic factors, and typically involve specific cell layers within the retina. A large number of simple Mendelian gene defects are known to affect the photoreceptor cell layer. As photoreceptor cells cannot be maintained in vitro, the study of animal models is instrumental in understanding the disease ...
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Disease models

Abstract Animal disease models provide valuable pre-clinical information to support progression of agents into human clinical studies. Examples of disease models by indication illustrate the diversity of the field.
Phil Ambery, Adrian Kilcoyne, Daniel O’Connor   +2 more
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Modeling Tick-Borne Disease: A Metapopulation Model

Bulletin of Mathematical Biology, 2006
Recent increases in reported outbreaks of tick-borne diseases have led to increased interest in understanding and controlling epidemics involving these transmission vectors. Mathematical disease models typically assume constant population size and spatial homogeneity. For tick-borne diseases, these assumptions are not always valid.
Gaff, Holly D., Gross, Louis J.
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Disease modeling in genetic kidney diseases: mice

Cell and Tissue Research, 2017
The mouse still represents arguably the most important mammal organism in research for modeling human genetic kidney diseases in vivo. Compared with many other mammal species, the breeding and maintenance of mice in the laboratory is relatively simple and cheap and reproduction cycles are short.
Andreas F, Hofmeister, Martin, Kömhoff, Stefanie, Weber, Ivica, Grgic   +3 more
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Disease modeling in genetic kidney diseases: zebrafish

Cell and Tissue Research, 2017
Growing numbers of translational genomics studies are based on the highly efficient and versatile zebrafish (Danio rerio) vertebrate model. The increasing types of zebrafish models have improved our understanding of inherited kidney diseases, since they not only display pathophysiological changes but also give us the opportunity to develop and test ...
Heiko, Schenk, Janina, Müller-Deile, Mark, Kinast, Mario, Schiffer   +3 more
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Disease model: LAMP-2 enlightens Danon disease

Trends in Molecular Medicine, 2001
Danon disease ('lysosomal glycogen storage disease with normal acid maltase') is characterized by a cardiomyopathy, myopathy and variable mental retardation. Mutations in the coding sequence of the lysosomal-associated membrane protein 2 (LAMP-2) were shown to cause a LAMP-2 deficiency in patients with Danon disease.
P, Saftig, Y, Tanaka, R, Lüllmann-Rauch, K, von Figura   +3 more
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