Results 181 to 190 of about 16,121,002 (311)

Animal Models for the Study of Human Disease

, 2013
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease.
Conn P.M.
core  

Animal Model Selection and Deep Phenotyping in Mitochondrial Genetic Diseases: Connecting Human Variants, Multisystem Pathology, and Preclinical Evidence. [PDF]

Genes (Basel)
Sasaki N, Watanabe M.
europepmc   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Animal models of GM2 gangliosidosis: utility and limitations

, 2016
Cheryl A Lawson,1,2 Douglas R Martin2,3 1Department of Pathobiology, 2Scott-Ritchey Research Center, 3Department of Anatomy, Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, AL, USA Abstract: GM2 gangliosidosis, a ...
Martin DR, Lawson CA
core  

Theratyping for personalized medicine across cystic fibrosis disease models. [PDF]

Commun Med (Lond)
Bezzerri V, Gunawardena T, Gonska T, Chan AP, Salih R, Lucca F, Moraes TJ, Freedman SD, Cipolli M.   +8 more
europepmc   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Unconventional animal models of Alzheimer's disease and aging: key insights from the UAMAA 2026 conference. [PDF]

Lab Anim (NY)
Garduño BM, Melgarejo T, Cogram P, Holmes TC, Xu X.   +4 more
europepmc   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Animal Disease Economic Impacts: A Survey of Literature and Typology of Research Approaches [PDF]

Animal diseases such as bovine spongiform encephalopathy (BSE) are a threat to the animal product marketing sector and the broader economy. Policy makers and industry stakeholders seek a means of assessing a disease threat's economic impacts when ...
Thilmany, Dawn D., Pritchett, James G., Johnson, Kamina K.   +2 more
core  

Human Induced Pluripotent Stem Cells in Rare Neurological Disorders: Opportunities and Challenges for Disease Modeling and Drug Discovery. [PDF]

Stem Cells Int
Harej Hrkać A, Rački V, Belančić A, Kriz J, Vitezić D, Mršić-Pelčić J, Acharya G, Varshney M, Pilipović K.   +8 more
europepmc   +1 more source