Results 211 to 220 of about 1,153,169 (268)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Dissecting NMOSD pathogenesis through animal models: a mechanism-oriented systems perspective. [PDF]

Front Immunol
Qiu S, Zhang Y, Wang X, Wang D, Zang X, Yang Q, Qv Y, Wang S, Han X.   +8 more
europepmc   +1 more source

Modernizing drug development and ensuring global equity in the organoid revolution. [PDF]

Commun Biol
Dzakah EE, Ni C, Feng X, Hu W, Zhao B, Tang S, Pang C.   +6 more
europepmc   +1 more source

Preclinical Rat Models in Oral Implant Dentistry: A Scoping Review of Study Design and Experimental Practices. [PDF]

Dent J (Basel)
Podda GM, Borghetti L, De Siati C, Galvez P, Romeo U, Catros S.   +5 more
europepmc   +1 more source

From Stress to Neurodegeneration: A New Look at the Pathogenesis of Parkinson's Disease. [PDF]

Biomedicines
Kazanskaya RB, Tsytsarev V, Volnova AB, Gainetdinov RR, Lopachev AV.   +4 more
europepmc   +1 more source

Animal models accurately representing acute liver failure (Review). [PDF]

Int J Mol Med
Luo S, Wu F, Jin Y, Huang X, Liu D, Tian B.   +5 more
europepmc   +1 more source

Reply to "Preclinical and Clinical Evidence on Chloroquine or Hydroxychloroquine in COVID-19": Achieving Statistical Significance Does Not Mean That Clinical Relevance Can Be Disregarded, and This Must Be Considered When Interpreting Results. [PDF]

Clin Transl Sci
Ben Ghezala I, Bardou M.
europepmc   +1 more source