Results 241 to 250 of about 10,577,757 (334)

The changing epidemiology of syphilis: new strategies for new challenges in China. [PDF]

Lancet Reg Health West Pac
Cao G, Jing H, Jie C, Liu M.
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Social factors are associated with disparities in epidemiological and operational indicators of COVID-19 surveillance in a region of the Brazilian Amazon. [PDF]

Front Public Health
Alencar JL, Dos Santos MPQ, da Silva Ferreira AL, Silva MJA, da Costa Lobato D, Dos Santos Freitas J, Kimura MAON, Guimarães RJPSE, Rodrigues YC, Sardinha DM, Lima KVB.   +10 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Identifying Gaps and Challenges in Acute Hepatitis B Surveillance in the Country of Georgia: Comprehensive Surveillance System Evaluation.

JMIR Public Health Surveill
Karichashvili L, Galdavadze K, Zakhashvili K, Tsereteli M, Ruadze E, Surguladze S, Stefanoff P.   +6 more
europepmc   +1 more source

Title X Parental Notification Regulation - A Different Prognosis [PDF]

, 1983
Diamond, Eugene F.
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Exploring the cause of the pertussis resurgence in England following the COVID-19 pandemic: a mathematical modelling study. [PDF]

BMC Infect Dis
Choi YH, van Leeuwen E, Miller E.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Spatial distribution and clustering of multidrug-resistant tuberculosis in Uganda: a nationwide ecological study (2014-2023)

Akello SR, Alunyo JP, Matovu JK, Emetu J, Oposhia J, Ssanyu GN, Bogere MN, Birungi P, Madenje M, Okalebo BC, Okiror W, Paasi G, Nsubuga S, Aujo D, Okibure A, Mukunya D, Olupot-Olupot P.   +16 more
europepmc   +1 more source