Results 241 to 250 of about 6,660,576 (307)

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Iron and the lung: emerging roles of iron metabolism in pulmonary disease pathogenesis and therapy. [PDF]

Eur Respir Rev
Galaris A, Toumpanakis D, Galaris D, Vassilakopoulos T, Pantopoulos K.   +4 more
europepmc   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

NETosis associates with human TB lung tissue destruction and disease pathogenesis. [PDF]

EMBO Mol Med
Fisher KL, Mpotje T, Nargan K, Moodley D, Rajkumar-Bhugeloo K, Baiyegunhi OO, Naidoo T, Madansein R, Sathekge M, Leslie A, Tomlinson G, Pollara G, Noursadeghi M, Steyn AJC, Ndung'u T, Marakalala MJ.   +15 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Integrative analysis of gut microbiota, plasma metabolome, and gene expression identifies causal mediators in Graves' disease pathogenesis. [PDF]

Front Microbiol
Zhang Y, Li J, Luo Y, Liu S, Liu J.
europepmc   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Metabolic dysfunction-associated steatotic liver disease: pathogenesis and novel treatment options. [PDF]

Mol Biomed
Ren R, Liang X, Wei X.
europepmc   +1 more source

The role of OTUD1-mediated deubiquitination in disease pathogenesis: from molecular mechanisms to clinical translation. [PDF]

Front Immunol
Wang Q, Zhang L, Cao H, Wang X, Luo T, Yin J.   +5 more
europepmc   +1 more source

Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn's disease pathogenesis. [PDF]

Nat Genet
Krzak M, Alegbe T, Taylor DL, Jones GR, Ghouraba M, Strickland M, Harris BT, Satti R, Arestang K, Ramirez-Navarro L, Nishad N, Cheam KAX, Tutert M, Ozols M, Noell G, Leonard S, Przybilla MJ, Suastegui CR, Khabirova E, Deng T, Najgebauer H, Petrova V, Jones CP, Wana N, Hu MX, Skelton J, Ostermayer J, Gu Y, Garri W, Brezina B, Caballes CQ, Corridoni D, Parkes M, Iyer V, Martin CC, McIntyre RE, Raine T, Anderson CA.   +37 more
europepmc   +1 more source